RESUMO
The results of the clinico-morphological studies carried out in 30 patients with the anterior-horn variety of amyotrophic lateral sclerosis (ALS) (CNS morphology was investigated in 6 cases) demonstrate this variety to be characterized by early fading of the tendinous periosteal reflexes, rapid development of amyotrophies, weak intensity of pyramid system lesions. This is supported by morphological studies of the CNS and allows advancing an opinion in favour of the priority of motoneuronal injury.
Assuntos
Esclerose Lateral Amiotrófica/diagnóstico , Encéfalo/patologia , Neurônios Motores/patologia , Medula Espinal/patologia , Adulto , Idoso , Esclerose Lateral Amiotrófica/classificação , Esclerose Lateral Amiotrófica/patologia , Braço/inervação , Diagnóstico Diferencial , Feminino , Humanos , Perna (Membro)/inervação , Masculino , Pessoa de Meia-Idade , Neurônios Motores/ultraestrutura , Atrofia Muscular/diagnóstico , Atrofia Muscular/patologia , Bainha de Mielina/ultraestrutura , Quadriplegia/diagnóstico , Quadriplegia/patologia , Reflexo Anormal/fisiologiaRESUMO
Methods aimed at the detection of causative agents in the CSF and peripheral blood lymphocytes are recommended for the use in intravital laboratory diagnosis of slow infections of the central nervous system. The results obtained enable recommending the biotest on guinea-pigs or indication of the causative agent of amyotrophic leukospongiosis (AL) in cell culture coupled with the punctate immunoenzyme assay for the diagnosis of AL. As to the diagnosis of Creutzfeldt-Jacob disease, it is suggested that the biotest on guinea-pigs and the punctate immunoenzyme assay may be used.
Assuntos
Encefalopatias/diagnóstico , Síndrome de Creutzfeldt-Jakob/diagnóstico , Doenças por Vírus Lento/diagnóstico , Adulto , Idoso , Animais , Anticorpos Antivirais/análise , Encefalopatias/líquido cefalorraquidiano , Encefalopatias/microbiologia , Líquido Cefalorraquidiano/microbiologia , Síndrome de Creutzfeldt-Jakob/líquido cefalorraquidiano , Síndrome de Creutzfeldt-Jakob/microbiologia , Modelos Animais de Doenças , Cobaias , Humanos , Linfócitos/microbiologia , Pessoa de Meia-Idade , Doenças por Vírus Lento/líquido cefalorraquidiano , Doenças por Vírus Lento/microbiologia , Vírus não Classificados/imunologia , Vírus não Classificados/isolamento & purificaçãoRESUMO
The paper is concerned with the results of a clinicomorphological analysis of 17 cases of Creutzfeld's-Jacob disease (CJD) in patients aged 39 to 78 years. The authors show polymorphism of the clinical manifestations at the early stages of the disease and the necessity of differentiation between atherosclerotic dementia and tumors of the profound parts of the brain and sometimes with the high pattern of lateral amyotrophic sclerosis. The problem of the clinical varieties of CJD is discussed.
Assuntos
Síndrome de Creutzfeldt-Jakob/diagnóstico , Adulto , Idoso , Esclerose Lateral Amiotrófica/diagnóstico , Encéfalo/patologia , Neoplasias Encefálicas/diagnóstico , Síndrome de Creutzfeldt-Jakob/patologia , Diagnóstico Diferencial , Feminino , Humanos , Arteriosclerose Intracraniana/diagnóstico , Masculino , Pessoa de Meia-IdadeRESUMO
The analysis of 7 cases of subacute spongiform encephalopathy, the Creutzfeldt-Jacob disease (CJD), is given. Three main morphological features are typical for this disease: spongiform change of the grey matter, progressive neuronal loss and proliferation of the astroglia cells. Unlike the other spongiform conditions, spongiform change in the CJD develops in neuropile of the brain grey matter. As a rule, the disease affects at first the cortex of the cerebral hemispheres, then subcortical nuclear groups, cerebellum and more rarely nuclear groups of the brain stem. The demyelinization of the white matter of the cerebral hemispheres is not obligatory for the CJD and appears in cases with a severe lesion of the grey matter.
