RESUMO
Catecholamine content has been studied in the adrenal gland of rat females whose pregnant mothers were loaded daily with L-methionine administered per os during all the pregnancy period, on the first day of postnatal life, and in one and two months after birth. The animal model of hyperhomocysteinemia used in the experiment has been shown to result in the catecholamine content decreasing in the adrenal gland of both newly born rat offspring with high serum level of homocysteine and one-month old offspring with their homocysteine level decreased to the normal values. It was found that nitrotyrosine level increased significantly in the blood serum of the offspring aged one and two months. The data obtained may testify to oxidative stress development.
Assuntos
Glândulas Suprarrenais/metabolismo , Catecolaminas/metabolismo , Hiper-Homocisteinemia/metabolismo , Metionina/efeitos adversos , Efeitos Tardios da Exposição Pré-Natal/metabolismo , Administração Oral , Glândulas Suprarrenais/fisiopatologia , Animais , Animais Recém-Nascidos , Modelos Animais de Doenças , Feminino , Hiper-Homocisteinemia/etiologia , Hiper-Homocisteinemia/fisiopatologia , Metionina/administração & dosagem , Estresse Oxidativo , Gravidez , Efeitos Tardios da Exposição Pré-Natal/etiologia , Efeitos Tardios da Exposição Pré-Natal/fisiopatologia , Ratos , Ratos Wistar , Tirosina/análogos & derivados , Tirosina/sangueRESUMO
Circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been studied in stomach cancer (n = 89) and colorectal cancer (n = 86) patients. The excretion of aMT6s was decreased in cancer patients. The disturbances of the circadian rhythm of aMT6s excretion have been observed in the cancer patients as well. These changes were directly proportional to the extent of cancer process and to the extent of lymphogenic metastasis.
Assuntos
Transtornos Cronobiológicos , Neoplasias Colorretais , Melatonina/análogos & derivados , Neoplasias Gástricas , Adulto , Fatores Etários , Idoso , Transtornos Cronobiológicos/etiologia , Transtornos Cronobiológicos/metabolismo , Ritmo Circadiano , Neoplasias Colorretais/complicações , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/patologia , Feminino , Humanos , Metástase Linfática , Masculino , Melatonina/metabolismo , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Gástricas/complicações , Neoplasias Gástricas/metabolismo , Neoplasias Gástricas/patologiaRESUMO
The aim of the research is investigation of the endometrial hormonal status during menstrual cycle infertile and infertile women. 68 endometrial biopsies from 18-45 years old women have been studied. Some changes of ER and PR expression during menstrual cycle both in fertile and infertile women has been founded. However the ER expression in endometrial stroma and PR in the glands in a proliferative stage of cycle of fertile women are higher than in a secretory stage. In infertile women the PR expression in endometrial glands is opposite.
Assuntos
Endométrio/metabolismo , Regulação da Expressão Gênica , Infertilidade Feminina/metabolismo , Ciclo Menstrual , Receptores de Estrogênio/biossíntese , Receptores de Progesterona/biossíntese , Adolescente , Adulto , Biópsia , Endométrio/patologia , Feminino , Humanos , Infertilidade Feminina/patologia , Pessoa de Meia-IdadeRESUMO
In investigations carried out with organotypic culture of mediobasal preoptic area (MPA) of hypothalamus it was established that pineal peptide preparations epitalon (2 ng/ml) and epithalamin (100 ng/ml) stimulate the development of proliferative activity of explants in 3 month and 24 months female rats. It has been shown that epithalamin is more effective in young rats in comparison with old animals, but epitalon as well as epithalamin have almost the same less pronounced inducing effect on growth zone in MPA explants from young and old animals. This effect is tissue specific and could be dependent on inhibition of apoptosis.
