Dominance Analysis of Bright and Dark Dispositional Predictors of Socially Desirable Responding.

Although the role of so-called dark traits in the prediction of maladaptive behavior has seen a large increase in interest by researchers, the Big Five still maintain their ubiquity in the prediction of most behaviors. This study uses measures of the Dark Tetrad and the Big Five personality traits to predict a very specific form of maladaptive behavior: the impression management form of socially desirable responding. In regression-based dominance analysis, results suggest that not all of the Big Five nor the Dark Tetrad provide statistically significant incremental validity but as a block, the Big Five dominate the Dark Tetrad in the prediction of the purposeful misrepresentation of one's self to others on self-report inventories. More specifically, four of the Big Five as well as the traits of Machiavellianism and sadism from the Dark Tetrad are significant predictors of impression management.

Antecedents and outcomes of work-family conflict: A mega-meta path analysis.

This study examines the mediating role of work-to-family conflict and family-to-work conflict between the Big Five personality traits and mental health thereby enhancing theoretical development based upon empirical evidence. Integrating Conservation of Resources theory with the self-medication hypothesis, we conducted a mega-meta analytic path analysis examining the relationships among employees' Big Five traits, work-to-family conflict and family-to-work conflict, anxiety and depression, and substance use. We produced a ten-by-ten synthetic correlation matrix from existing meta-analytic bivariate relationships to test our sequential mediation model. Results from our path analysis model showed that agreeableness and conscientiousness predicted substance use via mediated paths through both work-to-family conflict and family-to-work conflict and sequentially through depression as well as through family-to-work conflict followed by anxiety. Extroversion and openness-to-experience had relatively weaker influences on substance use through work-to-family conflict, anxiety, and depression. Neuroticism was the strongest driver of the two forms of conflict, the two mental health conditions, and substance use. From this model it can be inferred that work-to-family conflict and family-to-work conflict may be generative mechanisms by which the impact of personality is transmitted to mental health outcomes and then to substance use when analyzed via a Conservation of Resources theory lens.

VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy.

Duchenne muscular dystrophy is characterized by structural degeneration of muscle, which is exacerbated by localized functional ischemia due to loss of nitric oxide synthase-induced vasodilation. Treatment strategies aimed at increasing vascular perfusion have been proposed. Toward this end, we have developed monoclonal antibodies (mAbs) that bind to the vascular endothelial growth factor (VEGF) receptor VEGFR-1 (Flt-1) and its soluble splice variant isoform (sFlt-1) leading to increased levels of free VEGF and proangiogenic signaling. The lead chimeric mAb, 21B3, had high affinity and specificity for both human and mouse sFlt-1 and inhibited VEGF binding to sFlt-1 in a competitive manner. Proof-of-concept studies in the mdx mouse model of Duchenne muscular dystrophy showed that intravenous administration of 21B3 led to elevated VEGF levels, increased vascularization and blood flow to muscles, and decreased fibrosis after 6-12 weeks of treatment. Greater muscle strength was also observed after 4 weeks of treatment. A humanized form of the mAb, 27H6, was engineered and demonstrated a comparable pharmacologic effect. Overall, administration of anti-Flt-1 mAbs in mdx mice inhibited the VEGF:Flt-1 interaction, promoted angiogenesis, and improved muscle function. These studies suggest a potential therapeutic benefit of Flt-1 inhibition for patients with Duchenne muscular dystrophy.

Impact of Social Desirability and Common Method Variance on Two Measures of Entitlement.

Entitlement is the predisposition toward expecting or demanding more rewards than someone else regardless of one's own contribution, effort, or performance. This study examines the impact of social desirability and common method variance on the discriminant validity of the two most popular measures of entitlement: The Psychological Entitlement Scale and the Entitlement subscale of the Narcissistic Personality Inventory. Data were gathered using three independent samples. In all three studies, forcing items to load on their intended and separate constructs measuring entitlement fit the data well thus providing some evidence of discriminant validity. The correlation between the two entitlement constructs was larger than in previous studies but short of that which is necessary for collinearity providing further evidence of discriminant validity in each study. In each study the amount of shared variance between the two latent entitlement constructs was more than the variance explained in either construct thus failing to provide evidence of discriminant validity. These two measures are similarly affected by socially desirable responding but not likely contaminated by common method variance. Because of their consistently and moderately strong correlation, the PES and the entitlement subscale of the NPI likely measure different but strongly related constructs.

Measurement invariance tests of revisions to archaically worded items in the Mach IV scale.

The Machiavellian IV [1] instrument, developed almost 50 years ago to measure trait Machiavellianism and still in wide use in personality research, uses item wording that is not gender-neutral, makes use of idiomatic expressions, and includes archaic references. In this two-sample study, exploratory factor analysis (EFA) was conducted on one sample to examine the structure of responses to the Mach IV. In an independent second sample the resulting EFA structure was analyzed using confirmatory factor analysis-based measurement equivalence/invariance (ME/I) tests in a control group with the original archaic items and a treatment group with eight items rewritten in a more modern vernacular. Specific model testing steps [2] and statistical tests [3] were applied in a bottom-up approach [4] to ME/I tests on these two versions of the Mach IV. The two versions were found to have equal form, equal factor loadings, but unequal indicator error variances. Subsequent item-by-item tests of error invariance resulted in substantial decrements to fit for three revised items suggesting that the error associated with these items was not equal across the two versions.

Meta-analysis of coefficient alpha for scores on the Narcissistic Personality Inventory.

The Narcissistic Personality Inventory (NPI) has greatly facilitated the scientific study of trait narcissism. However, there is great variability in the reported reliability of scores on the NPI. This study meta-analyzes coefficient alpha for scores on the NPI and its sub-scales (e.g. entitlement) with transformed alphas weighted by the inverse of the variance of alpha. Three coders evaluated 1213 individual studies for possible inclusion and determined that 1122 independent samples were suitable for coding on 12 different characteristics of the sample, scale, and study. A fourth author cross-coded 15 percent of these samples resulting in 85 percent overall agreement. In the independent samples, comprised of 195,038 self-reports, the expected population coefficient alpha for the NPI was .82. The population value for alpha on the various sub-scales ranged from .48 for narcissistic self-sufficiency to .76 for narcissistic leadership/authority. Because significant heterogeneity existed in coded study alphas for the overall NPI, moderator tests and an explanatory model were also conducted and reported. It was found that longer scales, the use of a Likert response scale as opposed to the original forced choice response format, higher mean scores and larger standard deviations on the scale, as well as the use of samples with a larger percentage of female respondents were all positively related to the expected population alpha for scores on the overall NPI. These results will likely aid researchers who are concerned with the reliability of scores on the NPI in their research on non-clinical subjects.

Clinical Practice Informs Secure Messaging Benefits and Best Practices.

Background Clinical care team members in Department of Veterans' Affairs (VA) facilities nationwide are working to integrate the use of Secure Messaging (SM) into care delivery and identify innovative uses. Identifying best practices for proactive use of SM is a key factor in its successful implementation and sustained use by VA clinical care team members and veterans. Objectives A collaborative project solicited input from VA clinical care teams about their local practices using SM to provide access to proactive patient-centered care for veterans and enhance workflow. Methods This project implemented a single-item cross-sectional qualitative electronic survey via internal e-mail to local coordinators in all 23 Veterans Integrated Service Networks (VISNs). Content analysis was used to manage descriptive data responses. Descriptive statistics described sample characteristics. Results VA clinical care team members across 15 of 23 VISNs responded to the questionnaire. Content analysis of 171 responses produced two global domains: (1) benefits of SM and (2) SM best practices. Benefits of SM use emphasize enhanced and efficient communication and increased access to care. Care team members incorporate SM into their daily clinical practices, using it to provide services before, during, and after clinical encounters as a best practice. SM users suggest improvements in veteran care, clinical team workflow, and efficient use of health resources. Clinical team members invested in the successful implementation of SM integrate SM into their daily practices to provide meaningful and useful veteran-centered care and improve workflow. Conclusion VA clinical care team members can use SM proactively to create an integrated SM culture. With adequate knowledge and motivation to proactively use this technology, all clinical team members within the VA system can replicate best practices shared by other clinical care teams to generate meaningful and useful interactions with SM to enrich veterans' health care experience.

Measurement of academic entitlement.

Members of Generation Y, or Millennials, have been accused of being lazy, whiny, pampered, and entitled, particularly in the college classroom. Using an equity theory framework, eight items from a measure of work entitlement were adapted to measure academic entitlement in a university setting in three independent samples. In Study 1 (n = 229), confirmatory factor analyses indicated good model fit to a unidimensional structure for the data. In Study 2 (n = 200), the questionnaire predicted unique variance in university satisfaction beyond two more general measures of dispositional entitlement. In Study 3 (n = 161), the measure predicted unique variance in perceptions of grade fairness beyond that which was predicted by another measure of academic entitlement. This analysis provides evidence of discriminant, convergent, incremental, concurrent criterion-related, and construct validity for the Academic Equity Preference Questionnaire.

A domain-specific validation of the core self-evaluations scale.

Core self-evaluations have been recently proposed as indicating positive self-concept and as being predictive of various forms of subjective wellbeing. In an effort to further validate the Core Self-Evaluations Scale (CSES), structural equation modeling (SEM) was employed in three independent samples of university students to examine the extent to which scores on the Core Self-Evaluations Scale predicted two measures of university satisfaction. Good fit was found for models that also controlled for status in college, student major, class satisfaction, life satisfaction, college grade point average, and overall grade fairness. Statistically significant relationships corrected for attenuation by SEM between scores on the Core Self-Evaluations Scale and university satisfaction range from .24 to .37.