1.
Pharmeur Sci Notes
; 2005(1): 5-10, 2005 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17687887
RESUMO
A reversed-phased liquid chromatographic method for the control of impurities of nine impurities in Chlortalidone drug substance is presented. The method is sufficiently sensitive to quantify down to the level of 0.0015 per cent equivalent to a concentration of 15 microg/ml.
Assuntos
Clortalidona/análise , Cromatografia Líquida de Alta Pressão/métodos , Contaminação de Medicamentos/prevenção & controle , Anti-Hipertensivos/análise , Anti-Hipertensivos/química , Clortalidona/química , Estabilidade de Medicamentos , Estrutura Molecular , Reprodutibilidade dos Testes
2.
Pharmeur Sci Notes
; 2005(1): 15-20, 2005 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17687889
RESUMO
An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has been validated and is capable of controlling impurities to 0.1 per cent.