Artificial intelligence in tongue diagnosis: classification of tongue lesions and normal tongue images using deep convolutional neural network.

OBJECTIVE: This study aims to classify tongue lesion types using tongue images utilizing Deep Convolutional Neural Networks (DCNNs). METHODS: A dataset consisting of five classes, four tongue lesion classes (coated, geographical, fissured tongue, and median rhomboid glossitis), and one healthy/normal tongue class, was constructed using tongue images of 623 patients who were admitted to our clinic. Classification performance was evaluated on VGG19, ResNet50, ResNet101, and GoogLeNet networks using fusion based majority voting (FBMV) approach for the first time in the literature. RESULTS: In the binary classification problem (normal vs. tongue lesion), the highest classification accuracy performance of 93,53% was achieved utilizing ResNet101, and this rate was increased to 95,15% with the application of the FBMV approach. In the five-class classification problem of tongue lesion types, the VGG19 network yielded the best accuracy rate of 83.93%, and the fusion approach improved this rate to 88.76%. CONCLUSION: The obtained test results showed that tongue lesions could be identified with a high accuracy by applying DCNNs. Further improvement of these results has the potential for the use of the proposed method in clinic applications.

Fractal characteristics of the trabecular pattern of the mandible in patients with renal transplantation.

OBJECTIVE: In this study, we examined the mandibular trabecular bone structures by performing fractal dimension (FD) analysis in patients who underwent renal transplantation (RTx). METHODS: Our study is an observational study with 69 RTx patients and 35 control group patients. The mean FD values of the patient and control groups were calculated and compared. In addition, biochemical parathyroid hormone (PTH), serum calcium, phosphorus, alkaline phosphatase (ALP), and vitamin-D parameters and FD values of both groups were analyzed. RESULTS: FD values were significantly lower in the patient group than in the healthy group (p < .05). In the RTx group compared to the control group, ALP (90.71 ± 34.25-66.54 ± 16.8, respectively) (p < .001) and PTH (75.76 ± 38.01-38.17 ± 12.39, respectively) (p < .001) values were higher. There was a positive correlation between the FD values and ALP (rspearman  = .305, p = .011) and a negative correlation between FD values and vitamin-D (rspearman  = .287, p = .017) of patients with RTx. CONCLUSION: FD values were found to be lower in patients who underwent RTx compared to the control group. It should be considered that FD analysis can be a method that can be used to evaluate trabecular bone structure in patients undergoing RTx.

Diagnosis of common intraosseous lesions of the dentomaxillofacial region by chemometry-assisted FT-IR spectroscopy in dental tissue samples.

PURPOSES: This study aimed to determine the differential diagnosis of three intraosseous lesions (odontogenic keratocyst (OKC), central giant cell granuloma (CGCG), and dentigerous cyst (DC)) of the dentomaxillofacial region with very similar radiological and clinical features by using chemometrics assisted FT-IR (Fourier transform infrared) spectroscopy in tissue samples. METHODS: Tissue samples (exposed to formaldehyde for a similar time) of 20-micron thickness belonging to 19 intraosseous lesions diagnosed histopathologically were obtained from the pathology laboratory. The samples were analyzed by FT-IR spectroscopic method using the 400-4000 cm-1 wavenumber range, and the obtained spectra of the samples were evaluated using the orthogonal partial least squares discriminant analysis (OPLS-DA) algorithm. RESULTS: The intraosseous lesions with different histopathological diagnoses were accurately and precisely clustered with different FT-IR bands corresponding to the main molecular vibrations, especially the phosphodiester region, of the tissue components using the proposed model with 3 latent variables. CONCLUSIONS: The model showed high sensitivity and specificity. The present study is the first to report the elucidation of clear spectral differences between similar lesions in the maxillofacial region. In the future, the FT-IR method may be used in the non-destructive classification of similar lesions in the maxillofacial region as an alternative to histopathological evaluation.

Comparison of artifact values of prosthodontic materials with 2 different cone beam computed tomography devices.

STATEMENT OF PROBLEM: Prosthodontic materials may cause unexpected artifacts in cone beam computed tomography (CBCT) images, but studies quantifying these artifacts are sparse. PURPOSE: The purpose of this in vitro study was to compare the artifact expression of fixed prosthodontic materials with different CBCT devices. MATERIAL AND METHODS: Ten prosthodontic materials (Co-Cr-Mo alloy, interim acrylic resin, polyetheretherketone, feldspathic ceramic, lithium disilicate glass-ceramic, zirconia-reinforced lithium silicate ceramic, zircon core, and 3 monolithic zirconias) were scanned with 2 CBCT devices. The materials were placed in polymethyl methacrylate resin to simulate clinical conditions. To assess the impact of the devices on artifacts, the gray values of 8 areas in each material image were analyzed. The data were analyzed with the Kruskal-Wallis and Wilcoxon Signed-Rank tests (α=.05). RESULTS: Statistically significant differences were found in the artifact expression of the materials (P<.001) and between CBCT devices (P<.001). CONCLUSIONS: The artifact expression of polymeric and ceramic materials in CBCT images was less than that of other materials. The milliampere-second (mAs) value of CBCT devices had a significant impact on the artifact level.

Dental implant brand and angle identification using deep neural networks.

STATEMENT OF PROBLEM: Determining the brand and angle of an implant clinically or radiographically can be challenging. Whether artificial intelligence can assist is unclear. PURPOSE: The purpose of the present study was to determine the brand and angle of implants from panoramic radiographs with artificial intelligence. MATERIAL AND METHODS: Panoramic radiographs were used to classify the accuracy of different dental implant brands through deep convolutional neural networks (CNNs) with transfer-learning strategies. The implant classification performance of 5 deep CNN models was evaluated using a total of 11 904 images of 5 different implant types extracted from 2634 radiographs. In addition, the angle of implant images was estimated by calculating the angle of 2634 implant images by applying a regression model based on deep CNN. RESULTS: Among the 5 deep CNN models, the highest performance was obtained in the Visual Geometry Group (VGG)-19 model with a 98.3% accuracy rate. By applying a fusion approach based on majority voting, the accuracy rate was slightly improved to 98.9%. In addition, the root mean square error value of 2.91 degrees was obtained as a result of the regression model used in the implant angle estimation problem. CONCLUSIONS: Implant images from panoramic radiographs could be classified with a high accuracy, and their angles estimated with a low mean error.

The findings of impacted and transmigrated maxillary and mandibular canines: a retrospective cone beam computed tomography study.

BACKGROUND: The aim of this study was to examine and evaluate the maxillary and mandibular impacted and transmigrant canines, their relationship with neighboring tissues and pathology with cone beam computed tomography (CBCT). METHODS: CBCT data of 217 patients, between January 2018 and December 2019, with a total of 293 impacted canines were retrospectively reviewed. Clinical records were also evaluated. Maxillary or mandibular localization, angulations, transmigration, lateral and premolar tooth resorption, apical dilacerations, pathological formations, presence of persistent deciduous canines and treatment methods were investigated. RESULTS: For 293 impacted canines, 237 were in the maxilla and 56 in the mandible, with this difference being statistically significant (P<0.05). Among the 293 impacted canines, 14 (4.8%) transmigrated canines were detected. From the 14 transmigrant canines, 13 were in the mandible and 1 was in the maxilla. This difference was found statistically significant (P<0.05). Eighteen dentigerous cysts (10 maxilla, 8 mandible) and 4 odontomas (3 maxilla, 1 mandible) were found in impacted canines. For a total of 293 impacted canines, 57 were extracted, 13 were referred to orthodontics and a follow-up decision was made for 223 teeth. CONCLUSIONS: Transmigration incidence is statistically significant, on a higher area of the lower jaw, compared to the upper jaw (P<0.05). In patients with impacted canines, taking CBCT together with a detailed clinical examination is effective in correct treatment planning and in minimizing complications that may occur during surgical extraction.

The Use of Artificial Intelligence in Dentistry Practices.

Artificial intelligence can be defined as "understanding human thinking and trying to develop computer processes that will produce a similar structure." Thus, it is an attempt by a programmed computer to think. According to a broader definition, artificial intelligence is a computer equipped with human intelligencespecific capacities such as acquiring information, perceiving, seeing, thinking, and making decisions. Quality demands in dental treatments have constantly been increasing in recent years. In parallel with this, using image-based methods and multimedia-supported explanation systems on the computer is becoming widespread to evaluate the available information. The use of artificial intelligence in dentistry will greatly contribute to the reduction of treatment times and the effort spent by the dentist, reduce the need for a specialist dentist, and give a new perspective to how dentistry is practiced. In this review, we aim to review the studies conducted with artificial intelligence in dentistry and to inform our dentists about the existence of this new technology.

The Investigation of Radiographic Findings of Mandibles on Panoramic Radiographs of Patients with Primary Hyperparathyroidism Using Fractal Analysis.

OBJECTIVE: The basis of the research is the application of fractal analysis (FA) to panoramic radiographs of patients with primary hyperparathyroidism (PHPT). In addition, the relationship between the relevant biochemistry parameters and fractal values of healthy controls and patients with PHPT will be evaluated. MATERIALS AND METHODS: In the current study, FA was performed with ImageJ program on panoramic radiographs of 48 patients diagnosed with PHPT. Fractal dimension (FD) values of the patients and 48 healthy subjects were compared. In addition, biochemical [parathyroid hormone (PTH), serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and vitamin D] parameters and FD values of both groups were analyzed with Mann-Whitney U-tests and Pearson correlation coefficient (P < .05). RESULTS: FD values of four different angular areas were significantly lower in the patient group than in the healthy group (P < .05). There was no statistically significant difference between the patient and control groups in the measurements between the apexes of the right and left premolar and molar teeth. The mean PTH, Ca, P, and vitamin D values of the patients with PHPT and control group were highly significant, and all the parameters of the patient group showed higher values than the control group except for the P values (P < .001). In the patient group and control group, there was no significant difference between mean ALP values (P = .48). No correlation was found between the two groups. CONCLUSION: Bone biopsy is the gold standard method for the diagnosis of bone structure changes in patients with PHPT. However, it is not used routinely because it is an invasive method. The FA method applied to panoramic radiographs may be used as a noninvasive, easy-to-apply method to reveal the changes in the trabecular structure of the jaw bones of the patients.

Buccal bifurcation cyst (paradental cyst) defined by ultrasonography and cone-beam computed tomography.

Buccal bifurcation cyst (BBC) is an uncommon inflammatory odontogenic cyst that generally occurs at the buccal region of the permanent mandibular first molars in children aged 6-8 years. The diagnosis of BBC cannot be made from the histopathologic features; therefore, diagnosis is primarily based on specific clinical and radiographic findings. In this case report, we present the clinical and radiological findings, including ultrasonography (USG) and cone-beam computed tomography (CBCT) images, of a 10-year-old boy who was referred with a complaint of swelling on the lower right jaw. According to the radiographic and clinical findings, the differential diagnosis of this lesion included lateral radicular cyst, lateral periodontal cyst, dentigerous cyst, eruption cyst, and others. Recently, in addition to classical radiographies and CBCT, USG has been considered important for diagnosis. In particular, if a cyst produces a perforation in the cortical bone, it is helpful to make a pre-diagnosis with USG.

Ultrasonography in determining pubertal growth and bone age.

OBJECTIVE:: The purpose of this study is to evaluate the compatibility of ultrasonographic data with hand-wrist radiographs taken to determine the extent of pubertal growth and bone age in patients and investigate the usability of ionizing radiation-free ultrasonography instead of conventional radiography. METHODS:: In this study, a total of 120 children from 10 to 17 years old (mean age was 168 months ± 27.5 months) were treated with routine radiographs before orthodontic treatment, and ultrasonographic imaging was performed on the wrists the same day. Researchers examined the phalanges, sesamoid bone, and radial bone distal epiphysis-diaphysis comparatively in each patient by both imaging methods and statistical evaluation. RESULTS:: There was no statistically significant difference between conventional radiography and ultrasonography values at 13 points except for PP1 (proximal phalanges of the first finger), PP2 (proximal phalanges of the second finger), and radial epiphysis (p > 0.05). PP1, PP2, and radial epiphysis showed a statistically significant difference (p < 0.05). The CBA (bone age obtained from conventional radiographs) of the females was found to be larger than their CA (chronological age) and their UBA (ultrasonographic bone age). For males; the means of the CBA, UBA and CA values close to each other. In females and males; there was a strong correlation between the CA, the UBA and the CBA (p < 0.01). CONCLUSION:: Ultrasonography gives detailed information about epiphyseal diaphysis relations. It can be used as an alternative to conventional radiography in the detection of bone age and pubertal growth, owing to the absence of ionizing radiation.

Fractal properties of the trabecular pattern of the mandible in chronic renal failure.

OBJECTIVES: The purpose of this study was to evaluate fractal analysis as a tool to quantitatively determine the mandibular trabecular bone changes in patients with chronic renal failure (CRF). METHODS: In the present study, fractal analysis was performed using ImageJ (National Institutes of Health, Bethesda, MD) program with box-counting method over panoramic radiographs of 25 patients (14 females and 11 males) with CRF and 26 healthy individuals (14 females and 12 males) as a control group. The fractal dimension (FD) values of the patients and healthy individuals were compared. In addition, average biochemical parameters [parathyroid hormone (PTH), calcium (Ca), phosphorus (P), product of Ca and P levels (CaxP), alkaline phosphatase (ALP), vitamin D] of the patients with CRF, as measured during the 3 months before the panoramic radiographs, were compared with FD values. RESULTS: According to the results, FD values of the patients with CRF were found to be statistically lower than the control group (p < 0.05). The average PTH levels of the patients with CRF were 416.16 ± 310.3 pg ml(-1); average Ca levels were 8.94 ± 1.2 mg dl(-1); average P levels were 5.76 ± 1.7 mg dl(-1); average CaxP values were 51.12 ± 15.03; average ALP levels were 83.44 ± 36.8 U l(-1); and the average vitamin D values were 19.43 ± 9.7 ng ml(-1). In addition, there was no significant correlation between FD values and the biochemical parameters of the patients, and there was no correlation between age, gender and FD. CONCLUSIONS: The FD values of the patients with CRF were lower than those of the controls. This finding suggests that FD analysis might be a promising simple and cost-effective tool for evaluating trabecular bone structure.

Changes in jawbones of male patients with chronic renal failure on digital panoramic radiographs.

OBJECTIVE: To compare the existence of gonial cortical bone thickness, antegonial index, mandibular canal bone resorption and gonial angle values and pathologies like ground-glass appearance in jawbones and brown tumor in male patients undergoing dialysis due to chronic renal failure and men from the healthy control group on panoramic radiographs. MATERIALS AND METHODS: Panoramic radiographs were taken from 80 male individuals in total (40 normal and 40 dialysis patients). Values obtained from the right and left sides of the mandible were summed and their means were calculated. Gonial cortical thickness, antegonial index and gonial angle values were assessed with the Student's t-test, mandibular canal wall resorption with the Chi-square test, and pathologies such as ground-glass appearance and Brown tumor as "available" or "not available." RESULTS: Statistically significant differences were observed among the antegonial index (P < 0.001), gonial cortical bone thickness (P < 0.001), and gonial angle (P < 0.001) values of study and control groups. Besides, mandibular canal wall resorption (P < 0.001) was also statistically significant. In the study group, pathologies with ground-glass appearance were encountered in mandible, but no radiographic findings were observed similar to brown tumor. CONCLUSIONS: Compared to the control group, decreases were found in gonial cortical bone thicknesses, antegonial index values, mandibular canal wall resorption, and gonial angle values of the patients receiving dialysis treatment due to chronic renal failure. Although it is not statistically significant, pathology with ground-glass appearance was detected in a patient, but no pathologies like brown tumor were observed. These findings from patients with chronic renal failure must be evaluated in panoramic radiography.

Clinical and radiological findings of a bilateral coronoid hyperplasia case.

Coronoid hyperplasia (CH) is an infrequent condition that can be defined as an abnormal bony elongation of histologically normal bone. Progressive and painless difficulty in opening the mouth is the main clinical finding of CH. In this case report, the clinical and radiological findings for a 23-year-old male patient with bilateral CH are presented. When plain radiographies are not sufficient for diagnosis and evaluation of the CH, cone-beam computed tomography can be used.

Unilateral bone cavities situated near the angle of the mandibula.

Stafne bone defects (SBDs) are asymptomatic radiolucent lingual/buccal bone lesions of the lower jaw and are frequently caused by soft tissue inclusion. These defects have a cystlike appearance on plain radiographs. The diagnosis of this defect is incidental because patients do not usually present clinical symptoms. The common variant of SBD exists at the third molar region of the mandible below the inferior alveolar canal. To date, only 1 case of multilocular SBD has been reported in the literature, including both clinical cases and archaeological specimens. The purpose of the current study was to describe a new case of multilocular appearance of SBD near the angle of the mandibula that was diagnosed with the aid of a three-dimensional cone beam computed tomographic scan.

Cone beam computed tomography imaging of ponticulus posticus: prevalence, characteristics, and a review of the literature.

OBJECTIVE: The aim of this study was to investigate the frequency of ponticulus posticus (PP) using cone beam computed tomography (CBCT) and to describe the radiologic characteristics of the detected cases. STUDY DESIGN: The presence and types of PP were investigated on 730 CBCT images. RESULTS: PP was found in 17.4% (127) of the 730 CBCT scans. Of these 127 patients, 79 (10.8%) had bilateral PP and 48 (6.6%) had unilateral PP. Male predominance was found with a prevalence of 19.5% (54 of 277) and female prevalence was 16.1% (73 of 453). The prevalence of PP increased with age; the highest prevalence of PP was seen in those who were 49 to 81 years of age. CONCLUSIONS: This study shows that PP is not an uncommon anatomic variation and is a natural incidental finding on CBCT.

Are all soft tissue calcifications detected by cone-beam computed tomography in the submandibular region sialoliths?

Heterotrophic soft tissue calcification occurs with the deposit of calcium salts in soft tissue rather than bone. The aim of this report is to describe cone-beam computed tomographic (CBCT) and ultrasonographic (US) findings of 2 cases of soft tissue calcifications that were initially diagnosed as submandibular or parotid sialolithiasis. Multiple soft tissue calcifications were evaluated by panoramic radiography, CBCT imaging, and US imaging in a 50-year-old male patient and a 30-year-old male patient. Calcifications were detected in the soft tissue of the submandibular area at axial, coronal, and multiplanar reformatted examinations and were prediagnosed as sialolithiasis. US examination was conducted to determine the complete relation between the soft tissues and the calcifications. In conclusion, high-resolution dental volumetric tomography with a low radiation dose is the optimal diagnostic tool to analyze the skeletal structure of the maxillofacial region in 3 dimensions. However, it is not sufficient to examine the soft tissues. US imaging is a useful diagnostic tool to evaluate the relation between the soft tissues and the calcifications in the submandibular area.

Dental age assessment for different climatic regions.

OBJECTIVE: The aim of this study was to evaluate the impact of several aspects of climate, such as temperature and altitude, on dental maturation. MATERIALS AND METHODS: The total sample consisted of 944 panoramic radiographs (473 Turkish children from Central Anatolia [228 girls and 245 boys] and 471 Turkish children from Eastern Anatolia [222 girls and 249 boys]). The children aged between 7.0 and 14.9 years. The radiographs were randomly selected from 2 cities in Turkey, Kayseri and Erzurum. Independent t tests and paired t tests were performed to compare sex, location, and age to determine the relationships between tooth developments. RESULTS: The Central Anatolian children were approximately 0.2 to 3.0 years more advanced in dental maturity than the Eastern Anatolian subjects. CONCLUSIONS: The development standards proposed by Demirjian are affected by climatic factors. However, further research and detailed information to gather data are needed.

A comparison of three different diabetes screening methods among dental patients in Turkey.

OBJECTIVE: This study was conducted to describe the frequency of diabetes in dental patients, and to compare three different screening methods: the random finger plasma glucose (RFPG) test, the Finnish diabetes risk score (FINDRISC) survey and a special clinical guideline developed for dental patients. METHODS: The study design was cross-sectional, descriptive and comparative. The data were collected between August 2011 and February 2012. A total of 702 dental patients participated in this study. The screening tools were RFPG, FINDRISC and a clinical guideline. Data were analyzed using the Chi-squared test, the t test, analysis of variance, and the Pearson correlation test. RESULTS: The frequency of diabetes was 8.3% for the participants. The prevalence of participants at risk for undiagnosed diabetes was 20.1% according to the RFPG test, 29.9% according to the FINDRISC, and 29.8% according to the clinical guideline. Correlation analysis showed a significant positive correlation between the screening methods (p<0.001 for each). CONCLUSION: The overall frequency of diabetes was 8.3%. It was found that the three screening methods used in this study were statistically similar. However, FINDRISC and clinical guideline as the questionnaire screening tools indicated a little larger group than RFPG with respect to diabetes risk.

Identification of the mandibular landmarks in a pediatric population

OBJECTIVE: The aim of this study was to determine and compare the reliability to accomplish of common mandibular landmarks and to determine the incidence of incisive canals, anterior looping, and lingual foramina in children from panoramic and CBCT images. DESIGN: Panoramic and CBCT images from 100 children and adolescent patients were randomly selected. In order to grade the visibility of mandibular anatomical landmarks, a four-point rating scale was used. RESULTS: In panoramic images, the mandibular canal could be observed in 92.5% of cases, with good visibility in 12.0%. The mental foramen could be observed in 44.5% of cases, while none had good visibility. Anterior looping of the mental nerve was present in 16.5% of the cases, and none had good visibility. An incisive canal could be identified in 22.5% of cases, with only 1.5% showing good visibility. The lingual foramen could be visualized in 61.0% of cases, with good visibility in 6%. In CBCT images, the mandibular canal, the mental foramen, and the lingual foramen could be observed in 100% of the cases, with good visibility in 51.0%, 98.5%, and 45.0% of cases, respectively. Anterior looping of the mental nerve was present in 26% of cases, with 2% having good visibility. An incisive canal could be identified in 49.5% of cases, with only 75% showing good visibility. CONCLUSIONS: This study confirms the applicability of CBCT images to visualize critical structures in children

Bone age assessment: the applicability of the Greulich-Pyle method in eastern Turkish children.

The aim of this study was to investigate whether or not the Greulich-Pyle (GP) method is adequate for Turkish children. A group of 767 individuals (425 girls and 342 boys) between 7 and 17 years were studied. Bone age (BA) from plain radiographs of left hands and wrists by GP standards was estimated. The total mean differences between BA and chronological age (CA) for girls and boys were found to be 0.20 and -0.13 years, respectively. There were significant differences between BA and CA in age groups 7-, 8-, 10-, 11-, 12-, 13-, 15-, and 16-year-olds for girls and 7-, 10-, and 12-year-olds for boys. The results of this study suggest that the mean differences between BA and CA are low enough to be of no practical significance, and thus, for the time being unless any other methods will be proved more useful, this method could be used in all age groups.