[Pain-alleviating action of gidifen and its combinations with analgesics]. / Izuchenie boleutoliaiushchego deistviia gidifena i ego sochetanii s anal'getikami.

The analgesic effect of gidifen, a new tranquilizer belonging to the group of organophosphorus compounds, manifests itself in relatively high doses (1/3 of the LD50). The quantitative characteristics of the analgesic action depends on the method for evaluating the analgesic action of the drug. On combined use of gidifen and analgesics applied in a definite dosage range the analgesic effect is potentiated. If the tranquilizer under study is combined with non-narcotic analgesics, the above potentiation is accompanied with an increase in the toxicity and myorelaxant activity of gidifen. On combination of the latter with morphine the parameters under consideration are unchanged. According to the pattern of interaction with analgesics gidifen does not differ in principle from benzodiazepine tranquilizers. However, the drug is not superior to benzodiazepines in this respect.

[Action of morphine and amidopyrine against a background of mineralocorticoid hormone and its antagonist]. / Deistvie morfina i amidopirina na fone mineralokortikoidnogo gormona i ego antagonista.

The effect of morphine and amidopyrine, used against the background of a mineralocorticoid hormone or its antagonist excess (multiple administration of desoxycorticosteron acetate or verospiron), is mitigated. The pain-allaying effect of analgesics and their influence on the behavioral reactions are less marked in both models than it is in intact animals and their toxocity is down.

[Action of aminazine and tisercin in a changed functional state of the body]. / Deistvie aminazina i tizertsina v usloviiakh izmenennogo funkstional'nogo sostoianiia organizma.

Experiments with rats evidenced that the pain-allaying and hypothermal action of chlorpromazine and tisercin (5 and 1 mg/kg) remains intact with an upset homeostasis against the background of a phlogogenic mixture and inflammation effect, though it becomes less potent. These drugs increase the higher permeability of the blood-histological barrier of the suprarenals caused by the stress (introduction of an irritating mixture) and inflammation.

[Neurotropic action of probon compared to amidopyrine]. / Neirotropnoe deistvie probona v sravnenii s amidopirinom.

In comparing the neurotropic action of probon and amidopyrine it became evident that both analgesics inhibit the behavioral reactions of rats in "open field" tests, fail to produce any protective action with respect to the reflex reaction of the heart in response to pain stimulation and attenuate such an effect of seduxen. By lengthening the hexobarbital-induced sleep probon and amidopyrine change the EEG nature typical of the effect produced by barbiturates. The difference between the study analgesics is rather a quantitative one, viz. in many rests probon is more potent and its action manifestes itself in a wider range of dosages.

[Effect of thyrocalcitonin on the pain sensitivity in animals]. / Effect tirokal'tsitonina na bolevuiu chuvstvitel'nost' zhivotnykh.

With a single parenteral introduction of thyrocalcitonin (TCT) the algesthesia of soft tissues (tall skin, paw) is moderately increasing, while the algesic action of morphine and promedol against the background of TCT-gets weaker. And contrarywise algesthesia of hard tissues of the tooth becomes significantly lower under the effect of TCT and this continues for a long time.