RESUMO
Clinical, echocardiographic, Doppler echocardiographic, electro- and phonocardiographic studies were performed in 31 patients with cardiac atherosclerotic lesions (aortic in 17 patients, aortomitral in 10, mitral in 4) and in 20 patients matched for age, sex, and underlying abnormality, but without cardiac disease. Atherosclerotic defects caused by calcification of the valvular apparatus were shown to be rarely (5.9% of patients) isolated, they were more frequently combined or concurrent. Atherosclerotic defects caused no significant myocardial structural and functional changes in addition to the underlying pathology. Aortic atherosclerotic stenosis is diagnosed at equal rates by using echo and phonocardiography, whereas aortic valvular insufficiency and mitral diseases are better (7- and 9-fold) detected with echocardiography and Doppler echocardiography, whereas aortic valvular insufficiency and mitral diseases are better (7- and 9-fold) detected with echocardiography and Doppler echocardiography than with phonocardiography.
Assuntos
Valva Aórtica , Arteriosclerose/diagnóstico , Valva Mitral , Isquemia Miocárdica/diagnóstico , Calcinose/diagnóstico , Ecocardiografia , Eletrocardiografia , Feminino , Testes de Função Cardíaca , Doenças das Valvas Cardíacas/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , FonocardiografiaRESUMO
Clinical, echoCG, PCG and ECG examinations were performed in 42 patients with primary isolated valve prolapses: mitral, aortal and tricuspid (32, 5 and 5 patients, respectively). It is shown that degree 1 regurgitation caused no hemodynamic disturbances, that of degree 2 and 3 brought about cardial complaints in more than half the patients, hemodynamic overstrain of the heart, sound symptoms similar to those of relevant valvular disease.
Assuntos
Prolapso da Valva Aórtica/fisiopatologia , Hemodinâmica/fisiologia , Prolapso da Valva Mitral/fisiopatologia , Prolapso da Valva Tricúspide/fisiopatologia , Adolescente , Adulto , Prolapso da Valva Aórtica/diagnóstico , Criança , Ecocardiografia , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prolapso da Valva Mitral/diagnóstico , Fonocardiografia , Prolapso da Valva Tricúspide/diagnósticoRESUMO
As a result of clinical and experimental observations the authors have established that even at the early stages of the nephrotic syndrome there occur myocardial lesions determined by concomitant impairment of microcirculation and metabolism leading to the development of nephrotic cardiomyopathy. The appearance of the nephrotic syndrome may be accompanied by the development of hydrothorax and more seldom, primarily in acute glomerulonephritis, by nephrogenous edema of the lungs. The nephrotic syndrome does not exert any material effect on the changes in external respiratory function, common to glomerulonephritis. Nephrotic gastropathy is of total character with low magnitudes of acid secretion and intragastric proteolysis. This does not create any conditions for acid-peptic damage to the gastroduodenal mucosa attended by ulcer formation.
Assuntos
Síndrome Nefrótica/patologia , Vísceras/patologia , Glomerulonefrite/patologia , Humanos , Microcirculação , Miocárdio/patologia , Testes de Função Respiratória , Estômago/patologiaAssuntos
Calcitonina/farmacologia , Coração/fisiopatologia , Hormônio Paratireóideo/farmacologia , Uremia/fisiopatologia , Potenciais de Ação/efeitos dos fármacos , Animais , Cálcio/metabolismo , Permeabilidade da Membrana Celular/efeitos dos fármacos , Técnicas In Vitro , Contração Miocárdica/efeitos dos fármacos , Miocárdio/metabolismo , Ratos , Ratos Endogâmicos , Sódio/metabolismoAssuntos
Cardiomegalia/fisiopatologia , Falência Renal Crônica/fisiopatologia , Contração Miocárdica , Miocárdio/metabolismo , Animais , Cardiomegalia/etiologia , Eletrocardiografia , Metabolismo Energético , Feminino , Humanos , Falência Renal Crônica/complicações , Masculino , Ratos , Ratos EndogâmicosRESUMO
The functional state of the myocardium was studied in 45 white Wistar rats in the early stages of chronic renal insufficiency. After resection of 4/6 of the renal parenchyma the initial stage of chronic renal insufficiency was created with the urea level in blood serum 7.0-10.0 mmol/l with normal content of electrolytes (duration of observation lasting 1.3 to 6 months). Towards the 3rd month myocardial hypertrophy developed in animals with statistically significant increase of the cardiac mass by 18-20%, not related to enhancement of haemodynamic load on the heart. Arterial pressure remains normal. Hypertrophy of the myocardium as shown by histochemistry was accompanied by increase of energy and protein metabolism, carbohydrates decreased simultaneously due to the decrease of myocardium tolerance to glucose.