TRUST-tPA trial: Telemedicine for remote collaboration with urgentists for stroke-tPA treatment.

Background Previous observational studies have shown that telemedicine is feasible and safe to deliver intravenous (IV) recombinant tissue plasminogen activator (rt-PA). However, implementation of telemedicine may be challenging. To illustrate this fact, we report a study showing that telemedicine failed to improve clinical outcome and analyze the reasons for this shortcoming. Methods We established a tele-stroke network of 10 emergency rooms (ERs) of community hospitals connected to a stroke center to perform a randomized, open-label clinical trial with blinded outcome evaluation. Eligible patients were randomly assigned to either a usual care arm (i.e. immediate transfer to the stroke center and administration of IV rt-PA if indication was confirmed upon stroke arrival) or tele-thrombolysis arm (i.e. immediate administration of IV rt-PA in ER and transfer to the stroke center). The primary efficacy outcome was an excellent outcome (modified Rankin scale (mRS) 0-1 at 90 days). Secondary endpoints included favorable outcome (90-day mRS 0-2) and early neurological improvement (NIHSS score 0-1 at 24 hours or a decrease of ≥ 4 points within 24 hours). Safety outcomes included symptomatic intracerebral hemorrhage (ICH) per ECASS II definition, any ICH and all-cause mortality. Results During an accrual time of 48 months, because of a slow enrollment rate, only 49 of 270 patients initially planned for inclusion were randomized into usual care ( n = 23) and tele-thrombolysis ( n = 26). Despite random assignment, patients allocated to tele-thrombolysis were older and had more severe stroke than patients allocated to usual care. The median duration of video-conference was 23 minutes in the usual care arm and 73 minutes in the tele-thrombolysis arm. Eighty-four percent of patients in the tele-thrombolysis arm were treated by IV rt-PA in comparison to 18% in the usual care arm. In univariate analysis but not after adjustment for age and baseline NIHSS, patients allocated in the usual care arm had a higher rate of excellent or favorable outcome. There were no differences in safety outcomes, with only one symptomatic ICH occurring in the tele-thrombolysis arm. Conclusions Stroke patients included in the telemedicine arm of the TRUST-tPA trial increased their rt-PA eligibility five-fold. However, the efficacy and safety remains to be determined (ClinicalTrials.org, NCT00279149).

Describing localized diseases in medical ontology: an FMA-based algorithm.

OntolUrgences is a termino-ontological resource developed to index and retrieve information in electronic Emergency Medical Record. In this project, we improved the ontology coverage to accommodate both anatomical and pathophysiological concepts in emergency medicine. This work lead to the automatic addition of 3,470 concepts and their underlying semantic formalization. In our method, we reuse and select the anatomical concepts relevant to emergency from FMA: To capture the anatomical specific concepts, (i) we involved Emergency practitioners and identified the key concepts from this domain; (ii) we applied an automatic algorithm to define the semantic relationships and integrated the result in the existing ontology.

Evaluation of the ventilator-user interface of 2 new advanced compact transport ventilators.

BACKGROUND: Mechanical ventilation during patient transport frequently utilizes compact portable pneumatic ventilators that have limited ventilator-settings options. New advanced transport ventilators should yield quality improvements, but their user-friendliness needs to be tested. OBJECTIVE: To evaluate the ventilator-user interface of 2 new transport ventilators. METHODS: This was a 2-center descriptive study in which the ventilator-user interfaces of the Oxylog 3000 and Elisée 250 were compared by 20 French senior emergency physicians who were initially unfamiliar with these ventilators. Each physician carried out 15 tasks with each ventilator and then assigned each ventilator a satisfaction score. RESULTS: With the Elisée 250 the task success rate was significantly higher (85.6% vs 66.6% with the Oxylog 3000, p < 0.0001), and the total number of errors was lower (46 vs 113). The main errors were related to inspiratory flow settings with the Oxylog 3000 (31 errors), inspiratory-expiratory ratio settings with the Elisée 250 (11 errors), ventilation mode choice with the Oxylog 3000 (17 errors), trigger sensitivity setting with the Elisée 250 (16 errors) and the Oxylog 3000 (11 errors), and alarm range setting with the Oxylog 3000 (10 errors). The mean satisfaction score was significantly better with the Elisée 250 (81% +/- 7, range 64-92%) than with the Oxylog 3000 (66% +/- 10, range 49-87%) (p < 0.0001). CONCLUSIONS: The Elisée 250 ventilator-user interface was easier to use than that of the Oxylog 3000. The applicability of these results to other types of users will require further studies, but the types of errors found in our study might help future users.