RESUMO
The data regarding the analysis of the physiological and biochemical mechanisms of muscle fatigue and ways to prevent it are summarized. The effect of the most common endogenous and exogenous antioxidants in the biochemical processes in muscle fatigue was analyzed. It is shown that biocompatible, non-toxic water-soluble C(60) fullerenes, which possess powerful antioxidative properties, promise great prospects in the correction of skeletal muscle fatigue caused by the destructive action of free radicals.
Assuntos
Acetilcisteína/farmacologia , Antioxidantes/farmacologia , Fulerenos/farmacologia , Fadiga Muscular/efeitos dos fármacos , Músculo Esquelético/efeitos dos fármacos , Alopurinol/farmacologia , Humanos , Terapia com Luz de Baixa Intensidade/métodos , Contração Muscular/efeitos dos fármacos , Contração Muscular/fisiologia , Fadiga Muscular/fisiologia , Músculo Esquelético/metabolismo , Músculo Esquelético/fisiopatologia , Estresse Oxidativo/efeitos dos fármacos , Espécies Reativas de Oxigênio/antagonistas & inibidores , Espécies Reativas de Oxigênio/metabolismoRESUMO
The experiments with rabbits show that animal maintenance on the antioxidant-free diet leads to the peroxidative lipid oxidation (PLO), hemostasis activation and to the superoxidedismutase (SOD) level reducing in a blood and tissues (of cerebrum, heart, kidney, stomach). The greatest SOD activity decreasing is observed in the cerebrum and heart tissues. Probably, these organs make the most considerable contribution in PLO and hemostasis course in the antioxidative reducing conditions.
Assuntos
Antitrombina III/antagonistas & inibidores , Dieta , Hemostasia/fisiologia , Peroxidação de Lipídeos , Superóxido Dismutase/metabolismo , Deficiência de Vitamina E/fisiopatologia , Animais , Especificidade de Órgãos , Coelhos , Superóxido Dismutase/sangueRESUMO
The experiments on rats have shown that an acute emotional-painful stress activates lipid peroxidation and caused hypercoagulation. The role of some organs (brain, heart, kidney, stomach) in those reactions was determined to be different: the brain tissues supplied the blood mainly with thromboplastin, but stomach--with activators of fibrinolysis; brain and heart tissues enhanced the antioxidative properties of the blood, while the stomach tissues reduced them. Such a peculiarity in changes in the lipid peroxidation and haemostasis at the emotional-painful stress should be taken into consideration at an analysis of a pathological process in above organs.
Assuntos
Hemostasia , Peroxidação de Lipídeos , Dor/metabolismo , Estresse Psicológico/metabolismo , Doença Aguda , Animais , Modelos Animais de Doenças , Masculino , Especificidade de Órgãos , Dor/sangue , Ratos , Ratos Wistar , Estresse Psicológico/sangueRESUMO
In vivo histoautoradiographic study of cerebral accumulation of exogenous histone after its intracarotid infusion to anesthetized rats with intact liver and animals with experimental cirrhosis showed that histone penetrates brain capillary endotheliocyte membranes and gets into the nervous tissue.
