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J Dermatol
; 50(1): e24-e25, 2023 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36093758
2.
J Dermatol
; 48(7): e331-e332, 2021 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33860561
3.
Drug Res (Stuttg)
; 67(2): 127-130, 2017 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27626609
RESUMO
The apoptotic effects of a novel antitumour agent (Rv-PEM01) prepared from 6 kinds of herbs, including Rhus verniciflua were investigated using flow cytometry and western blot analysis. Rv-PEM01 induced apoptosis but not necrosis in MOLT-3, KG-1, and K562 human leukaemia cell lines. Further, Rv-PEM01-treated cells showed significantly upregulated expression of caspase-3 and 9 and cleaved caspase-3 and 9 compared to the control cells. Taken together, the results suggest that Rv-PEM01 induced apoptosis via the mitochondrial-mediated pathway, and is a potential natural anticancer agent and/or a functional food material.