RESUMO
The application of magnetic resonance imaging method showed that ischemia/hypoxia of the brain of neonatal rats made by the protocol suggested by Levine-Rice induces one-sided lesions in the areas of cerebral cortex, striatum and hippocampus. Unilateral ischemic injury leads to a long-term sensorimotor and behavioral distortions within 90-115 days after the operation which has been tested in animals by the battery of tests including Cylinder, Beam-walking, Staircase and Limb-placing test. Chosen battery of tests in combination with magnetic resonance imaging allows to reliably estimate the long-term sensorimotor recovery in adult animals suffered an injury in neonatal age.
Assuntos
Animais Recém-Nascidos , Córtex Cerebral/efeitos dos fármacos , Hipóxia-Isquemia Encefálica/patologia , Animais , Córtex Cerebral/lesões , Corpo Estriado/patologia , Retroalimentação Sensorial , Hipocampo/efeitos dos fármacos , Hipocampo/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , RatosRESUMO
Immuno-corrective action of the medication has been proved by analyzing Mildronate administration in 64 patients with bronchial asthma and secondary immunodeficiency. Stimulation of sell component and inhibition of humoral component of the immunity system, improvement of central hemodynamics and normalization of the hemopoiesis system to some extent have been observed in the patients. The patients with chronic catarrhal obstructive bronchitis in acute stage and patients with infection-allergic bronchial asthma showed decrease in bronchial obstruction under the treatment with the medication.
