Topical versus interlesional mitomycin C in auricular keloids

Background: The Keloid is an elevated fibrous scar that may extend beyond the borders of the original wound.ObjectTo compare between topical and intralesional mitomycin C in the treatment of auricular keloids.Patients and methodsProspective randomized study in which 40 patients with auricular keloids were included. The patients were divided into 2 groups, Group I included 32 patients who underwent topical mitomycin C application after the surgical removal of the auricular keloids, while Group II included 8 cases who underwent intra-lesional injection of mitomycin C after surgical removal of the auricular keloids.ResultsThe two groups showed no significant difference regarding patient or lesion criteria (p>.05). VSS decreased significantly from 10.63 and 11.0 down to 1.38 and 3.0 after treatment in the topical and intra-lesional groups respectively (p<.001). However, greater improvement and satisfaction was detected in the topical group.ConclusionBoth topical and intra-lesional mitomycin C injection are effective methods in managing auricular keloids. However, better VSS scores and patient satisfaction are reported with topical administration. (AU)

Antecedentes: El queloide es una cicatriz fibrosa elevada que puede extenderse más allá de los límites de la herida original.Objetivo Comparar mitomicina C tópica frente a intralesional en el tratamiento de los queloides auriculares.Pacientes y métodosEstudio prospectivo aleatorio en el que se incluyó a 40 pacientes con queloides auriculares, que se dividieron en 2 grupos: el Grupo I incluyó 32 pacientes a quienes se aplicó mitomicina C tópica tras la resección quirúrgica de los queloides, y el Grupo II que incluyó 8 casos, a quienes se inyectó mitomicina C dentro de la lesión, tras la resección quirúrgica de los queloides auriculares.ResultadosLos 2 grupos no reflejaron diferencia significativa en cuanto a criterios de pacientes o lesión (p>0,05). La escala de Vancouver (VSS) disminuyó significativamente de 10,63 y 11 a 1,38 y 3 tras el tratamiento en los grupos de aplicación tópica e intra-lesional, respectivamente (p<0,001). Sin embargo, se detectaron una mejora y satisfacción más altas en el grupo de aplicación tópica.ConclusiónLas aplicaciones tópica e inyectada de mitomicina C son métodos efectivos para el tratamiento de queloides auriculares. Sin embargo, se reportaron mejores puntuaciones VSS y de satisfacción del paciente con la administración tópica. (AU)

Topical versus interlesional mitomycin C in auricular keloids.

BACKGROUND: The Keloid is an elevated fibrous scar that may extend beyond the borders of the original wound. OBJECT: To compare between topical and intralesional mitomycin C in the treatment of auricular keloids. PATIENTS AND METHODS: Prospective randomized study in which 40 patients with auricular keloids were included. The patients were divided into 2 groups, Group I included 32 patients who underwent topical mitomycin C application after the surgical removal of the auricular keloids, while Group II included 8 cases who underwent intra-lesional injection of mitomycin C after surgical removal of the auricular keloids. RESULTS: The two groups showed no significant difference regarding patient or lesion criteria (p>.05). VSS decreased significantly from 10.63 and 11.0 down to 1.38 and 3.0 after treatment in the topical and intra-lesional groups respectively (p<.001). However, greater improvement and satisfaction was detected in the topical group. CONCLUSION: Both topical and intra-lesional mitomycin C injection are effective methods in managing auricular keloids. However, better VSS scores and patient satisfaction are reported with topical administration.