Effects of Succinate-Containing Preparation on Characteristics of Rat Erythrocytes in Exhaustive Swimming with a Load.

We studied the dynamics of the red blood cell composition of Wistar male rats at rest and when swimming with a load (4% body weight) before and after administration of a succinatecontaining preparation (meso-2,3-dimercaptosuccinic acid). In rats receiving the succinatecontaining preparation, a decrease in the number of red blood cells and an increase in their volume and absolute and relative number of reticulocytes were observed at rest in comparison with vivarium control. In rats exposed to exhaustive swimming after preliminary administration of the test preparation (12 h before the test), we observed a decrease in hematocrit and erythrocyte diameter in comparison with the corresponding parameters in rats not treated with the preparation; the level of hemoglobin did not change. The pattern of changes in the cellular composition of red blood in rats at rest and during swimming against the background of treatment with the succinate-containing preparation in comparison with vivarium control is considered as a result of its effect on physical exercise under conditions of stabilization of hemoglobin and hematocrit levels, activation of proliferative activity of red bone marrow, and an increase in time of swimming to exhaustion by 2.8 times.

[Migration activity of microlymphocytes in the blood of calfs subjected to physical conditioning].

A specific role of microlymphocytes in the generating cell-mediated immunity of animals at the early ontogenesis was shown. A delay of migration activities of microlymphocytes under the effect of stress and physical tension seems to take place. A positive effect of age-related muscular tension in animals is observed in contrast to the action ofhypodynamia on the migration activity of microlymphocytes and their level in the blood.

[Effect of motor activity of different intensity upon the blood composition and respiratory function in domestic animals during their first months of life].

Responses of the blood content, breathing function and gaseous metabolism to changes of motional activity level in calves in the first 30 days of a postnatal period were investigated. Keeping of calves in conditions natural for mature animals at different motor activity levels as compared with the locomotion limitation leads to a lesser reduction of hemoglobin content, haematocrit ratio, red cells and reticulocytes count in blood of calves during first 30 days of life. In comparison with calves with additional motor activity, 10-day old calves with natural motor activity and locomotion limitation showed an increase of the protein level and reduction of glucose and cholesterol in the blood. Locomotion limitation of calves during the first 30 days of postnatal period caused reduction of the blood oxygen carrying capacity (erythrocytes and reticulocytes count) with simultaneous decrease of breathing function and gaseous metabolism efficiency (breathing output, minute ventilation, carbon dioxide output and oxygen uptake).

[Nuclear-cytoplasmic ratio and shape of erythroid cells of the reindeer embryo]. / Iaderno-tsitoplazmaticheskoe otnoshenie i forma éritroidnykh kletok u émbrionov severnogo olenia.

With the beginning of normoblastic erythropoiesis the nuclear-cytoplasmic ratio (NCR) in the erythroid cells increases. From the chromatophilic erythroblasts with NCR from 1.0 and more erythrocytes possessing the concavo-concave form are produced as a result of the nucleus elimination.