Valores de referencia del antígeno prostático específico (PSA) en 63.926 trabajadores sin síntomas prostáticos que participaron en el cribado de cáncer de próstata desarrollado por la Sociedad de Prevención de Ibermutuamur durante el año 2006 / Reference values of prostate specific antigen (PSA) in 63926 workers without prostatic symptoms who participated in prostate screening cancer developed by the Ibermutuamur Prevention Society in 2006

Objetivo: Determinar los valores de referencia de PSA en trabajadores españoles sin antecedentes de problemas prostáticos y compararlos con otras latitudes geográficas. Métodos: Estudio observacional, retrospectivo, multicéntrico y con base poblacional realizado entre 01 de enero y 31 de diciembre de 2006. De los 65.303 trabajadores que participaron en el Programa de cribado del cáncer de próstata realizada por la Sociedad de Prevención de Ibermutuamur en diferentes regiones españolas. De ellos, fueron seleccionados para este informe, 63926: 149 fueron excluidos por historia personal de problemas prostáticos y 1.328 por ser mayores de 64 años. Las determinaciones de PSA se realizaron mediante la prueba de Abbott. Se especificaron los valores de PSA para cada edad y para los rangos de edad: menores de 40 años, 40–49 años, 50–59 años y 60–64 años. También se calcularon las medias de los valores de PSA por Comunidades Autónomas. Los datos fueron expresados como media (±DE), los intervalos de confianza al 95%, error estándar de la media (SEM) y en los percentiles 5, 25, 50, 75 y 95. Los resultados obtenidos fueron comparados con los de otras zonas del mundo. Todos los datos fueron analizados utilizando el programa estadístico GraphPad Quick Calculs. Resultados: Valor medio de PSA: para todos los casos fue de 1,06ng/ml (95% IC: ±1,18); por grupos de edades: menores de 40 años, 0,67ng/ml (95% IC: ±0,49), 40–49 años, 0,77ng/ml (95% IC: ±0,66), 50–59 años, 1,11ng/ml (95% IC: ±1,22) y 60–64 años, 1,57ng/ml (95% IC: ±1,72). Según la edad, osciló entre 0,67ng/ml menores de 40 años y 1,70 en los 64 años. Por Comunidades Autónomas, el valor más bajo se registró en el País Vasco con 0,98ng/ml (95% CI: 1,02) y mayor en Asturias con 1,28ng/ml (95% CI: 1,32). Valores del PSA según percentil: el límite superior (percentil 95) fue de 1,40ng/ml en aquellos menores de 40 años, 1,70ng/ml en 40–49 años, 3,30ng/ml en 50–59 años y 5,18ng/ml en el grupo de 60–64 años. Conclusiones: Los valores de PSA recogidos en este estudio podrían servir de referencia para población española en edad, utilizando el rango descrito por décadas, o mejor aún, los correspondientes a cada edad (AU)

Objective: To determine the values of PSA in Spanish workers without history of prostate problems and compare them with other geographical latitudes. Methods: Observational, retrospective, multicenter and population-based study, conducted between January 1 and December 31, 2006. A total of 65303 workers participated in the Programme of prostate cancer screening conducted by the Ibermutuamur Prevention Society in different Spanish regions. Of these, were selected for this report, 63926: 149 were excluded by personal history of prostate problems and 1328 for being over 64 years. PSA determinations were performed using the Abbott test. Were specified PSA values for each age and for the following age ranges: younger than 40 years, 40–49 years, 50–59 years and 60–64 years. Also calculated the mean PSA values by Autonomous Communities. The data were expressed as mean (±SD), confidence intervals 95%, standard error of the mean (SEM) and in the percentiles 5, 25, 50, 75 and 95. The results obtained were compared with those in other areas of the world. All data were analysed using the statistical software GraphPad Quick Calcs. Results: Mean PSA value: for all cases was 1.06ng/ml (95% CI: ±1,18) and age groups: under 40 years, 0.67ng/ml (95% CI: ±0.49), 40–49 years, 0, 77ng/ml (95% CI: ±0.66), 50–59 years, 1.11ng/ml (95% CI: ±1.22) and 60–64 years, 1.57ng/ml (95% CI: ±1.72). Depending on the age ranged between 0.67ng/ml under age 40 and 1.70 in the 64 years. According to region, the lowest value was recorded in the País Vasco with 0.98ng/ml (95% CI: 1.02) and higher in Asturias with 1.28ng/ml (95% CI: 1.32). Percentile value PSA: the upper normal limit (95th percentile) was 1.40ng/ml in those younger than 40 years, 1.70ng/ml in 40–49 years, 3.30ng/ml in 50–59 years and 5.18ng/ml in the group 60–64 years. Conclusions: PSA values collected in this study may serve as a reference for the Spanish working population, using the range described for decades, or even better, those relating to each age (AU)

[Reference values of prostate specific antigen (PSA) in 63926 workers without prostatic symptoms who participated in prostate screening cancer developed by the Ibermutuamur Prevention Society in 2006]. / Valores de referencia del antígeno prostático específico (PSA) en 63.926 trabajadores sin síntomas prostáticos que participaron en el cribado de cáncer de próstata desarrollado por la Sociedad de Prevención de Ibermutuamur durante el año 2006.

OBJECTIVE: To determine the values of PSA in Spanish workers without history of prostate problems and compare them with other geographical latitudes. METHODS: Observational, retrospective, multicenter and population-based study, conducted between January 1 and December 31, 2006. A total of 65303 workers participated in the Programme of prostate cancer screening conducted by the Ibermutuamur Prevention Society in different Spanish regions. Of these, were selected for this report, 63926: 149 were excluded by personal history of prostate problems and 1328 for being over 64 years. PSA determinations were performed using the Abbott test. Were specified PSA values for each age and for the following age ranges: younger than 40 years, 40-49 years, 50-59 years and 60-64 years. Also calculated the mean PSA values by Autonomous Communities. The data were expressed as mean (+/-SD), confidence intervals 95%, standard error of the mean (SEM) and in the percentiles 5, 25, 50, 75 and 95. The results obtained were compared with those in other areas of the world. All data were analysed using the statistical software GraphPad Quick Calcs. RESULTS: Mean PSA value: for all cases was 1.06 ng/ml (95% CI: +/-1,18) and age groups: under 40 years, 0.67 ng/ml (95% CI: +/-0.49), 40-49 years, 0, 77 ng/ml (95% CI: +/-0.66), 50-59 years, 1.11 ng/ml (95% CI: +/-1.22) and 60-64 years, 1.57 ng/ml (95% CI: +/-1.72). Depending on the age ranged between 0.67 ng/ml under age 40 and 1.70 in the 64 years. According to region, the lowest value was recorded in the País Vasco with 0.98 ng/ml (95% CI: 1.02) and higher in Asturias with 1.28 ng/ml (95% CI: 1.32). Percentile value PSA: the upper normal limit (95th percentile) was 1.40 ng/ml in those younger than 40 years, 1.70 ng/ml in 40-49 years, 3.30 ng/ml in 50-59 years and 5.18 ng/ml in the group 60-64 years. CONCLUSIONS: PSA values collected in this study may serve as a reference for the Spanish working population, using the range described for decades, or even better, those relating to each age.