RESUMO
Accurate mark of macrobiopsy site, carried out borderline or malignant lesions, is very important for surgeons. We report a woman case, 68 year's old, who presents intraductal carcinoma diagnoses on macrobiopsy. On postbiopsy X-ray, we can note lipiodol used instead of clip to reaper macrobiopsy site. Our observation shows how lipiodol use is not adapted into this indication.
Assuntos
Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/patologia , Meios de Contraste/administração & dosagem , Óleo Iodado/administração & dosagem , Idoso , Biópsia/métodos , Feminino , Humanos , Instrumentos CirúrgicosRESUMO
Sex mismatch is a well-known risk factor for chronic rejection of liver allografts, but the mechanisms involved remain unclear. Since experimental observations suggest that female liver is more sensitive to reperfusion injury than male liver, we assessed the influence of gender on oxidative stress. Livers from male and female rats were exposed to warm ischemia and reperfused by an oxygenated buffer. Chemiluminescence was continuously recorded. Reduced and oxidized glutathione and malondialdehyde lactic dehydrogenase values were also determined. Chemiluminescence increased during reperfusion in both groups, but was significantly greater in livers from female rats. Malondyaldehyde and lactic dehydrogenase progressively increased in all animals, reaching significantly greater values in female rats. Livers from female rats showed an increase in all the parameters of oxidative stress compared to male animals. A greater susceptibility to reperfusion injury may be evoked as an alternative mechanism to explain the poor outcome of female organ after liver transplantation.
Assuntos
Hepatopatias/etiologia , Traumatismo por Reperfusão/etiologia , Animais , Feminino , Hepatopatias/patologia , Medições Luminescentes , Masculino , Ratos , Ratos Wistar , Traumatismo por Reperfusão/patologia , Fatores SexuaisAssuntos
Rejeição de Enxerto , Sobrevivência de Enxerto , Transplante de Fígado/fisiologia , Sepse , Análise Atuarial , Adolescente , Adulto , Bilirrubina/sangue , Ciclosporina/uso terapêutico , Humanos , Imunossupressores/uso terapêutico , Transplante de Fígado/imunologia , Transplante de Fígado/mortalidade , Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade , Estudos Retrospectivos , Cidade de Roma , Análise de Sobrevida , Resultado do TratamentoRESUMO
The role of donor, preoperative, intraoperative, and postoperative factors in predicting patient survival after liver transplantation was evaluated by the Bio Medicus data package on a database containing 162 variables filled with records from 100 consecutive first-liver transplant cases. Donor data did not predict outcome. Recipient preoperative data (Child status, HCV status) were predictive using life table and Cox regression methods. Recipient intraoperative data (by-pass time, warm ischemia time, delay in arterial revascularization, and packed red blood cell requirements) were predictive of outcome using life table analysis. Recipient post-operative data (rejection, sepsis, primary dysfunction, and hepatic artery thrombosis) were predictive of outcome.