Retorno social de la inversión tras eliminar la transmisión vertical de chagas, VIH/sida, HB y sífilis: caso de un municipio de la Provincia de Buenos Aires / Social Return on the investment of the elimination of the vertical transmission of Chagas, HIV / AIDS, HB and Syphilis: Case of a Municipality of the Province of Buenos Aires

Resumen Introducción: se busca cuantificar los retornos de la inversión asociados a una intervención en el sistema público de salud de un municipio de la Provincia de Buenos Aires, Argentina, consistente en el fortalecimiento de la estrategia denominada Eliminación de la Transmisión Maternoinfantil de la Infección por VIH, Sífilis, enfermedad de Chagas Congénita e Infección Perinatal por Hepatitis B (ETMI-PLUS). Metodología: el estudio (cuantitativo) se basa en la metodología de Retorno Social de la Inversión (RSI). Se establecieron definiciones ad-hoc para la medición de los retornos sobre la base de los datos disponibles provenientes de diversas fuentes: información primaria de la Secretaría de Salud del MAB; tasas de transmisión congénita de cada enfermedad notificados al Sistema Nacional de Vigilancia de Salud; presupuestos detallados de los recursos asignados al proyecto por parte de la Fundación Mundo Sano y costos de tratamientos e insumos de nomencladores oficiales. Resultados: por cada peso invertido para reforzar la ETMI-PLUS en el MAB, se obtuvo un retorno de casi 4 pesos, gracias a las mejoras en la eliminación vertical de las cuatro enfermedades y al descenso de las complicaciones cardiacas en las mujeres embarazadas diagnosticadas con chagas y tratadas oportunamente. Conclusiones: estos resultados sugieren la existencia de una relación retorno-inversión favorable, analizada bajo una perspectiva conservadora, ya que, se incluyen exclusivamente los ahorros para el sistema de salud y se excluyen otras dimensiones de los retornos vinculadas con las mejoras en los resultados alcanzados.

Abstract Introduction: we seek to quantify the returns on investment associated with an intervention in the public health system of a Municipality of the Province of Buenos Aires, Argentina. This intervention consists of strengthening the strategy for the Elimination of Mother-to-Child Transmission of HIV Infection, Syphilis, Congenital Chagas Disease and Perinatal Hepatitis B Infection, a strategy called ETMI-PLUS. Methodology: the study (quantitative) is based on the Social Return on Investment (RSI) methodology. Ad-hoc definitions are established for the measurement of returns based on the information available from various sources: primary information from the Ministry of Health of the MAB; rates of congenital transmission of each disease reported to the National Health Surveillance System; detailed budgets of the resources assigned to the project by Fundación Mundo Sano and costs of treatments and supplies from official nomenclators. Results: for each argentinean peso invested in strengthening the ETMI-PLUS in the MAB, a return of almost 4 pesos would have been obtained thanks to the improvements in the vertical elimination of the 4 diseases and the reduction of cardiac complications in pregnant women.Conclusions: these results suggest the existence of a return / investment relationship favorable to the intervention, analyzed under a conservative analysis since savings for the health system are exclusively included and other dimensions of returns associated with improvements in results are excluded.

Early Poverty and Future Life Expectancy with Disability among the Elderly in Argentina: Pobreza Temprana y Esperanza de Vida Futura con Discapacidad entre los Adultos Mayores de la Argentina.

Two aspects of the ageing process in Latin America should be specially taken into account in order to evaluate future perspectives of morbidity among the elderly in the region: 1) Cohorts who will compose the bulk of the elderly population in the 21st century in Latin America survived to old age largely because of improvements in medicine and to a much lesser extent to amelioration of living standards, as is the case in high income countries; 2) a high proportion of the Latin American population still live in poor economic conditions and even these vulnerable individuals continue to experience gains in (adult and older adult) survival. We aim to evaluate to what an extent recent levels of poverty and indigence among young children in Argentina could impact future levels of disability and demands for long-term care of older people. Our results show that given the levels of poverty and indigence in childhood observed between 1988 and 1994 and given the relationship between poor early conditions and the risk of being disabled among the elderly in Argentina, life expectancy with disability at age 60 old would increase substantially between 2000 and 2040 both in absolute and relative terms.

Safe and unsafe abortions: Total monetary costs and health care system costs in Argentina in 2018. / Abortos seguros e inseguros: Costos monetarios totales y costos para el sistema de salud de la Argentina en 2018.

During the first semester of 2018, a profound debate on the legalization of the practice of abortion was initiated in Argentina, which exposed the lack of scientific studies addressing the economic dimension of abortion in this country. This work seeks to move forward in the quantification of the costs of abortion under two scenarios: the current context of illegality and the potential costs if the recommended international protocols were applied in a context of legalization of the practice. The results of the comparison between, on the one hand, the total monetary costs in 2018 (private or out-of-pocket expenditure and costs for the health care system) of the current scenario of illegality and unsafe practice of abortion and, on the other hand, potential scenarios of safe practices, shows that a large amount of resources could be saved if the recommended protocols were implemented. These results proved to be robust after carrying out a series of sensitivity exercises on the main assumptions included in the comparisons.

Durante el primer semestre de 2018, en Argentina se inició un profundo debate sobre la legalización de la práctica del aborto, que puso en evidencia la falta de estudios científicos que aborden la dimensión económica del tema en la Argentina. Este trabajo busca avanzar en la cuantificación de los costos del aborto bajo dos escenarios: el del actual contexto de ilegalidad y los costos potenciales si se aplicaran los protocolos internacionales recomendados, en un contexto de legalización de la práctica. Los resultados de la comparación de los costos monetarios totales en 2018 (privados o de bolsillo y para el sistema de salud) del escenario actual de ilegalidad y práctica insegura del aborto, frente a escenarios potenciales de prácticas seguras, muestran que se podría ahorrar una gran cantidad de recursos si se implementaran los protocolos recomendados. Dichos resultandos, además, se muestran robustos al realizar una serie de ejercicios de sensibilidad sobre los principales supuestos incluidos en las comparaciones.

Abortos seguros e inseguros: Costos monetarios totales y costos para el sistema de salud de la Argentina en 2018 / Safe and unsafe abortions: Total monetary costs and health care system costs in Argentina in 2018

RESUMEN Durante el primer semestre de 2018, en Argentina se inició un profundo debate sobre la legalización de la práctica del aborto, que puso en evidencia la falta de estudios científicos que aborden la dimensión económica del tema en la Argentina. Este trabajo busca avanzar en la cuantificación de los costos del aborto bajo dos escenarios: el del actual contexto de ilegalidad y los costos potenciales si se aplicaran los protocolos internacionales recomendados, en un contexto de legalización de la práctica. Los resultados de la comparación de los costos monetarios totales en 2018 (privados o de bolsillo y para el sistema de salud) del escenario actual de ilegalidad y práctica insegura del aborto, frente a escenarios potenciales de prácticas seguras, muestran que se podría ahorrar una gran cantidad de recursos si se implementaran los protocolos recomendados. Dichos resultandos, además, se muestran robustos al realizar una serie de ejercicios de sensibilidad sobre los principales supuestos incluidos en las comparaciones.

ABSTRACT During the first semester of 2018, a profound debate on the legalization of the practice of abortion was initiated in Argentina, which exposed the lack of scientific studies addressing the economic dimension of abortion in this country. This work seeks to move forward in the quantification of the costs of abortion under two scenarios: the current context of illegality and the potential costs if the recommended international protocols were applied in a context of legalization of the practice. The results of the comparison between, on the one hand, the total monetary costs in 2018 (private or out-of-pocket expenditure and costs for the health care system) of the current scenario of illegality and unsafe practice of abortion and, on the other hand, potential scenarios of safe practices, shows that a large amount of resources could be saved if the recommended protocols were implemented. These results proved to be robust after carrying out a series of sensitivity exercises on the main assumptions included in the comparisons.

Población mayor en situación de dependencia de la Argentina: Propuesta de clasificación según severidad basada en datos secundarios

a magnitud de la población de 65 años y más en situación de dependencia de la Argentina sería de más de un millón de personas. Dada la gran heterogeneidad en el tipo y en la intensidad de las ayudas que requieren las personas en situación de dependencia, resulta esencial establecer criterios de clasificación para identificar grupos homogéneos en términos de severidad.Objetivo: el trabajo busca establecer una metodología y unos criterios objetivos que permitan identificar grupos homogéneos de personas en situación de dependencia sobre la base de información secundaria (y limitada).Métodos: el método utilizado se basa en el Baremo de Valoración de la Situación de Dependencia (BVD) vigente en España y en la aplicación de la metodología de Arboles de Clasificación, bajo la función rpart del programa R. Las principales fuentes de información son la Encuesta sobre Discapacidad, Autonomía personal y Situaciones de Dependencia de España (EDAD, 2008) y la Encuesta Nacional sobre Calidad de Vida de los Adultos Mayores de la Argentina (ENCaViAM, 2012).Resultados: el modelo seleccionado arroja un elevado grado de ajuste sugiriendo que es posible estimar la distribución de la población mayor en situación de dependencia según grado de severidad de manera razonable a partir de un grupo reducido de variables.Conclusiones: si bien la prevalencia de la dependencia de las personas mayores sería mayor en la Argentina respecto a lo obervado en España, la importancia relativa de los grupos con mayor severidad sería menor en el primer país (en Argentina).

he magnitude of the population 65 years and over in dependency status (ie, people with long-term care need) in Argentina would be more than one million people. Given the great heterogeneity in the type and intensity of the aid required by individuals with long-term care need, it is essential to establish some criteria to classify those in homogeneous groups in terms of severity.Objective: This work aims to establish a methodology and objective criteria that allow the identification of homogeneous groups of people in dependency status on the basis of secondary (and limited) information.Methods: The method used is based on the Valuation Scale of Dependency Situation from Spain and on the application of the Classification Trees method under the rpart function of the R program. The main sources of information are the Survey on Disability, Personal Autonomy and Dependency Situations from Spain (EDAD, 2008) and the National Survey on Quality of Life of the Elderly from Argentina (ENCaViAM, 2012).Results: the model selected shows a high degree of adjustment suggesting that it is possible to estimate the distribution of the elderly population in dependency status according to their severity level in a reasonable way from a reduced group of variables.Conclusions: although the prevalence of dependency among the elderly would be higher in Argentina than in Spain, the relative importance of groups with greater severity would be lower in the first country (in Argentina).

[Excess weight and disability among the elderly in Argentina]. / Exceso de peso y discapacidad en las personas mayores de la Argentina.

The aim of this paper is to analyze the relationship between excess weight and the condition of disability among elderly people in Argentina and to assess the extent to which a protective factor could be operating that reduces or mitigates the effect of overweight on the loss of functional skills in people over 64 years of age. In order to do so, microdata from Argentina's 2009 National Survey of Risk Factors [Encuesta Nacional de Factores de Riesgo] was utilized. To measure the association among overweight, obesity and disability status, as well as the interaction of weight status and age, logistic regression models were estimated. The results indicate that although overweight and obesity have a positive net effect on the occurrence of disabilities, this effect is lower among people 64 years of age and older. This result could be suggesting that among older people a protective factor is at work that, while not reversing the direct relationship between excess weight and disability, seems to attenuate it.

Exceso de peso y discapacidad en las personas mayores de la Argentina / Excess weight and disability among the elderly in Argentina

El objetivo del presente trabajo es analizar la relación entre el exceso de peso y la condición de discapacidad en las personas mayores de la Argentina y evaluar en qué medida podría estar operando algún factor protector que reduzca o atenúe el efecto del exceso de peso sobre la pérdida de capacidades funcionales en las personas mayores de 64 años. Para ello se utilizan los microdatos de la Encuesta Nacional de Factores de Riesgo 2009. Con el objeto de medir la asociación entre sobrepeso, obesidad y la condición de discapacidad, así como la interacción de la condición de peso y la edad, se estiman modelos de regresión logística. Los resultados indican que, si bien el sobrepeso y la obesidad tendrían un efecto neto positivo sobre la presencia de discapacidades, este sería menor entre las personas de 64 años y más. Los resultados sugieren que entre las personas mayores existe algún factor protector, que si bien no revierte la relación directa entre exceso de peso y discapacidad, parece atenuarla.

The aim of this paper is to analyze the relationship between excess weight and the condition of disability among elderly people in Argentina and to assess the extent to which a protective factor could be operating that reduces or mitigates the effect of overweight on the loss of functional skills in people over 64 years of age. In order to do so, microdata from Argentina's 2009 National Survey of Risk Factors [Encuesta Nacional de Factores de Riesgo] was utilized. To measure the association among overweight, obesity and disability status, as well as the interaction of weight status and age, logistic regression models were estimated. The results indicate that although overweight and obesity have a positive net effect on the occurrence of disabilities, this effect is lower among people 64 years of age and older. This result could be suggesting that among older people a protective factor is at work that, while not reversing the direct relationship between excess weight and disability, seems to attenuate it.

[The origin and quality of water for human consumption: the health of the population residing in the Matanza-Riachuelo river basin area in Greater Buenos Aires]. / Origen y calidad del agua para consumo humano: salud de la población residente en el área de la cuenca Matanza-Riachuelo del Gran Buenos Aires.

The aim of this study is to analyze the origin and quality of water used for consumption in a sample of households in Matanza-Riachuelo river basin area in Greater Buenos Aires, Argentina. The results of drinking water by source indicated that 9% of water samples from the public water system, 45% of bottled water samples and 80% of well water samples were not safe for drinking due to excess content of coliforms, Escherichia coli or nitrates. Individuals living in households where well water is the main source of drinking water have a 55% higher chance of suffering a water-borne disease; in the cases of diarrheas, the probability is 87% higher and in the case of dermatitis, 160% higher. The water for human consumption in this region should be provided by centralized sources that assure control over the quality of the water.

Origen y calidad del agua para consumo humano: salud de la población residente en el área de la cuenca Matanza-Riachuelo del Gran Buenos Aires / The origin and quality of water for human consumption: the health of the population residing in the Matanza-Riachuelo river basin area in Greater Buenos Aires

El objetivo del estudio es analizar el origen y la calidad del agua domiciliaria utilizada para el consumo, en una muestra de hogares del área de la cuenca Matanza-Riachuelo del Gran Buenos Aires, Argentina. Según su origen, el 9% de las muestras de agua provenientes de la red pública, el 45% de las de agua envasada y el 80% de las provenientes de perforaciones o pozos individuales resultaron no potables por exceso de coliformes, Escherichia coli o nitratos. Los individuos de la muestra de hogares en los que la fuente principal de agua para el consumo eran pozos individuales presentaron una probabilidad 55% superior de padecer alguna enfermedad de origen hídrico, probabilidad que llegaría al 87% en el caso de las diarreas y al 160% en el de las dermatitis. El agua para consumo humano en este territorio debería provenir de fuentes centralizadas que aseguren el control de la calidad del agua.

The aim of this study is to analyze the origin and quality of water used for consumption in a sample of households in Matanza-Riachuelo river basin area in Greater Buenos Aires, Argentina. The results of drinking water by source indicated that 9% of water samples from the public water system, 45% of bottled water samples and 80% of well water samples were not safe for drinking due to excess content of coliforms, Escherichia coli or nitrates. Individuals living in households where well water is the main source of drinking water have a 55% higher chance of suffering a water-borne disease; in the cases of diarrheas, the probability is 87% higher and in the case of dermatitis, 160% higher. The water for human consumption in this region should be provided by centralized sources that assure control over the quality of the water.

Origen y calidad del agua para consumo humano: salud de la población residente en el área de la cuenca Matanza-Riachuelo del Gran Buenos Aires / The origin and quality of water for human consumption: the health of the population residing in the Matanza-Riachuelo river basin area in Greater Buenos Aires

El objetivo del estudio es analizar el origen y la calidad del agua domiciliaria utilizada para el consumo, en una muestra de hogares del área de la cuenca Matanza-Riachuelo del Gran Buenos Aires, Argentina. Según su origen, el 9% de las muestras de agua provenientes de la red pública, el 45% de las de agua envasada y el 80% de las provenientes de perforaciones o pozos individuales resultaron no potables por exceso de coliformes, Escherichia coli o nitratos. Los individuos de la muestra de hogares en los que la fuente principal de agua para el consumo eran pozos individuales presentaron una probabilidad 55% superior de padecer alguna enfermedad de origen hídrico, probabilidad que llegaría al 87% en el caso de las diarreas y al 160% en el de las dermatitis. El agua para consumo humano en este territorio debería provenir de fuentes centralizadas que aseguren el control de la calidad del agua.(AU)

The aim of this study is to analyze the origin and quality of water used for consumption in a sample of households in Matanza-Riachuelo river basin area in Greater Buenos Aires, Argentina. The results of drinking water by source indicated that 9% of water samples from the public water system, 45% of bottled water samples and 80% of well water samples were not safe for drinking due to excess content of coliforms, Escherichia coli or nitrates. Individuals living in households where well water is the main source of drinking water have a 55% higher chance of suffering a water-borne disease; in the cases of diarrheas, the probability is 87% higher and in the case of dermatitis, 160% higher. The water for human consumption in this region should be provided by centralized sources that assure control over the quality of the water.(AU)

Origen y calidad del agua para consumo humano: salud de la población residente en el área de la cuenca Matanza-Riachuelo del Gran Buenos Aires. / [The origin and quality of water for human consumption: the health of the population residing in the Matanza-Riachuelo river basin area in Greater Buenos Aires].

The aim of this study is to analyze the origin and quality of water used for consumption in a sample of households in Matanza-Riachuelo river basin area in Greater Buenos Aires, Argentina. The results of drinking water by source indicated that 9

of water samples from the public water system, 45

of bottled water samples and 80

of well water samples were not safe for drinking due to excess content of coliforms, Escherichia coli or nitrates. Individuals living in households where well water is the main source of drinking water have a 55

higher chance of suffering a water-borne disease; in the cases of diarrheas, the probability is 87

higher and in the case of dermatitis, 160

higher. The water for human consumption in this region should be provided by centralized sources that assure control over the quality of the water.

Dengue en la Argentina: un análisis económico del impacto de la epidemia de 2009 / Dengue in Argentina: an economic analysis of the impact of the 2009 epidemic

El presente estudio estima la carga económica de los casos notificados de dengue durante la epidemia argentina de 2009. Entre los costos considerados, se encuentran los costos médicos para el tratamiento de las personas afectadas y los costos de oportunidad de aquellas personas que dejaron de trabajar o estudiar a causa de la enfermedad. Para la determinación de los costos, a fines de 2009 se llevó a cabo una encuesta ad hoc a 201 hogares en los que habitaban personas que habían padecido la enfermedad durante la epidemia. Los resultados obtenidos permiten estimar entre los 26 y los 40 millones de pesos (entre 6 y 9 millones de dólares) el costo total de los casos notificados. Las regiones del norte argentino son las que habrían soportado la mayor carga económica (más del 90% de la carga total). Para todas las regiones, el costo social de un caso de dengue representaría más del 40% de la remuneración neta mensual promedio de los individuos.

The present study estimates the economic burden associated with the cases of dengue recorded during the 2009 Argentine epidemic. Among the costs considered are the medical costs necessary for the treatment of those affected and the opportunity costs for those who stopped working or studying because of the disease. In order to assess the costs of the disease, at the end of 2009 an ad-hoc survey was carried out in 201 households where people that had contracted dengue during the 2009 epidemic lived. The results allow us to estimate between 26 to 40 million Argentine pesos (6 to 9 million US dollars) as the total cost of the recorded cases. The regions in the north of Argentina bore the highest economic burden of the disease (more than 90% of the total burden). For all regions, the social cost of one dengue case accounts for more than 40% of the average monthly net individual income.

Dengue en la Argentina: un análisis económico del impacto de la epidemia de 2009 / Dengue in Argentina: an economic analysis of the impact of the 2009 epidemic

El presente estudio estima la carga económica de los casos notificados de dengue durante la epidemia argentina de 2009. Entre los costos considerados, se encuentran los costos médicos para el tratamiento de las personas afectadas y los costos de oportunidad de aquellas personas que dejaron de trabajar o estudiar a causa de la enfermedad. Para la determinación de los costos, a fines de 2009 se llevó a cabo una encuesta ad hoc a 201 hogares en los que habitaban personas que habían padecido la enfermedad durante la epidemia. Los resultados obtenidos permiten estimar entre los 26 y los 40 millones de pesos (entre 6 y 9 millones de dólares) el costo total de los casos notificados. Las regiones del norte argentino son las que habrían soportado la mayor carga económica (más del 90% de la carga total). Para todas las regiones, el costo social de un caso de dengue representaría más del 40% de la remuneración neta mensual promedio de los individuos.(AU)

The present study estimates the economic burden associated with the cases of dengue recorded during the 2009 Argentine epidemic. Among the costs considered are the medical costs necessary for the treatment of those affected and the opportunity costs for those who stopped working or studying because of the disease. In order to assess the costs of the disease, at the end of 2009 an ad-hoc survey was carried out in 201 households where people that had contracted dengue during the 2009 epidemic lived. The results allow us to estimate between 26 to 40 million Argentine pesos (6 to 9 million US dollars) as the total cost of the recorded cases. The regions in the north of Argentina bore the highest economic burden of the disease (more than 90% of the total burden). For all regions, the social cost of one dengue case accounts for more than 40% of the average monthly net individual income.(AU)

[Dengue in Argentina: an economic analysis of the impact of the 2009 epidemic]. / Dengue en la Argentina: un análisis económico del impacto de la epidemia de 2009.

The present study estimates the economic burden associated with the cases of dengue recorded during the 2009 Argentine epidemic. Among the costs considered are the medical costs necessary for the treatment of those affected and the opportunity costs for those who stopped working or studying because of the disease. In order to assess the costs of the disease, at the end of 2009 an ad-hoc survey was carried out in 201 households where people that had contracted dengue during the 2009 epidemic lived. The results allow us to estimate between 26 to 40 million Argentine pesos (6 to 9 million US dollars) as the total cost of the recorded cases. The regions in the north of Argentina bore the highest economic burden of the disease (more than 90% of the total burden). For all regions, the social cost of one dengue case accounts for more than 40% of the average monthly net individual income.

Obesity and excess mortality among the elderly in the United States and Mexico.

Increasing levels of obesity could compromise future gains in life expectancy in low- and high-income countries. Although excess mortality associated with obesity and, more generally, higher levels of body mass index (BAI) have been investigated in the United States, there is little research about the impact of obesity on mortality in Latin American countries, where very the rapid rate of growth of prevalence of obesity and overweight occur jointly with poor socioeconomic conditions. The aim of this article is to assess the magnitude of excess mortality due to obesity and overweight in Mexico and the United States. For this purpose, we take advantage of two comparable data sets: the Health and Retirement Study 2000 and 2004 for the United States, and the Mexican Health and Aging Study 2001 and 2003 for Mexico. We find higher excess mortality risks among obese and overweight individuals aged 60 and older in Mexico than in the United States. Yet, when analyzing excess mortality among different socioeconomic strata, we observe greater gaps by education in the United States than in Mexico. We also find that although the probability of experiencing obesity-related chronic diseases among individuals with high BMI is larger for the U.S. elderly, the relative risk of dying conditional on experiencing these diseases is higher in Mexico.

Effect of early conditions on disability among the elderly in Latin America and the Caribbean.

Poor early conditions have been associated with increasing risks of some chronic diseases during adulthood. Since chronic illnesses are known to be important risk factors for disability, poor early conditions should predict disability at older ages. In addition, recent literature suggests that poor early conditions may affect the risk of disability even in the absence of chronic illnesses. We aimed to evaluate the magnitude of differentials in the risk of being disabled according to early conditions experienced by elderly populations in Latin America and the Caribbean, and to identify the group of chronic illnesses responsible for it. We find that poor early conditions exert a strong influence on disability later in life in two ways: by increasing the risk of suffering disability-related chronic illnesses and by increasing the risks of suffering disabilities by those with chronic illnesses.

Obesidad y Esperanza de Vida en México Obesity and life expectancy in Mexico.

The high and increasing prevalence of overweight and obesity in Latin American and the Caribbean and the increasing prevalence of some obesity-related chronic diseases could be changing the current mortality patterns and the improvements in life expectancy of this population. The main objective of this study is to measure the effect of overweight and obesity on mortality in Mexico among elderly people (60 years and older). We use the Mexican Health and Ageing Study (MHAS, 2001 and 2003) that is a panel nationally-representative study of the population 50 years and older in Mexico. Our results show that excess body weight (defined by the two highest quintiles of Body Mass Index-BMI-) increases the risk of mortality at 60 years and older in Mexico. As much as 11% of the deaths among elderly that occurred during the period 2001-2003 in Mexico would have been avoided if overweight and obese people (individuals belonging to the highest two quintiles of BMI) had had the "ideal" weight (defined by the middle quintile, or third quintile, of BMI). At individual level, we estimate that individuals 60 years old with excess body weight (fourth and fifth quintiles of BMI) survive four years less, in average, than individuals with normal body weight (third quintile of BMI).