TRPV1 regulates inflammatory process in the tongue of surgically induced xerostomia mouse.

BACKGROUND: The aim of study is to investigate the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on xerostomia-induced inflammatory response in vivo. METHODS: Parotid, submandibular, and lingual gland were removed for xerostomia induction. The expression of inflammatory cytokines, TRPV1, NFkB, and MAPK in xerostomia was evaluated and compared in both TRPV1 wild and knockout mice. RESULTS: The level of interleukin-6 (IL-6) and IL-17, neutrophil/CD4 T-cell infiltration, phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase, TRPV1, and the localization of NFkB were elevated in xerostomia-induced TRPV1 wild-type mice. In contrast, inflammatory cytokines and MAPK were decreased in xerostomia-induced TRPV1 knockout mice. TRPV1 antagonist treatment also reduced tongue ulceration, neutrophil/CD4+ T-cell expression, IL-6, and IL-17 in TRPV1 wild-type mice. CONCLUSION: TRPV1 had a crucial role in modulating inflammation in xerostomia and targeting TRPV1 might be a promising therapeutic strategy for xerostomia.

Eigen damping constant of spin waves in ferromagnetic nanostructure.

Though varying in nature, all waves share traits in a way that they all follow the superposition principle while also experiencing attenuation as they propagate in space. And thus it is more than common that a comprehensive investigation of one type of wave leads to a discovery that can be extended to all kinds of waves in other fields of research. In the field of magnetism, the wave of interest corresponds to the spin wave (SW). Specifically, there has been a push to use SWs as the next information carriers similar to how electromagnetic waves are used in photonics. At present, the biggest impediment in making SW-based device to be widely adapted is the fact that the SW experiences large attenuation due to the large damping constant. Here, we developed a method to find the SW eigenmodes and show that their respective eigen damping constants can be 40% smaller than the typical material damping constant. From a bigger perspective, this finding means that the attenuation of SW and also other types of waves in general is no more constrained by the material parameters, and it can be controlled by the shape of the waves instead.

Unidirectional Magnon-Driven Domain Wall Motion Due to the Interfacial Dzyaloshinskii-Moriya Interaction.

We demonstrate a unidirectional motion of a quasiparticle without explicit symmetry breaking along the space-time coordinate of the particle motion. This counterintuitive behavior originates from a combined action of two intrinsic asymmetries in the other two directions. We realize this idea with the magnon-driven motion of a magnetic domain wall in thin films with interfacial asymmetry. Contrary to previous studies, the domain wall moves along the same direction regardless of the magnon-flow direction. Our general symmetry analysis and numerical simulation reveal that the odd order contributions from the interfacial asymmetry is unidirectional, which is dominant over bidirectional contributions in the realistic regime. We develop a simple analytic theory on the unidirectional motion, which provides an insightful description of this counterintuitive phenomenon.

Relation between switching time distribution and damping constant in magnetic nanostructure.

It is widely known that the switching time is determined by the thermal stability parameters and external perturbations such as magnetic field and/or spin polarized current in magnetic nano-structures. Since the thermal stability parameter and switching time are crucial values in the design of spin-transfer torque magnetic random access memory, the measurement of the switching time is important in the study of the switching behavior of ferromagnetic nano-structures. In this study, we focus on the distribution of the switching time. Within the limit of a large energy barrier, a simple analytical expression between damping constant and anisotropy field with switching time distribution is obtained and confirmed by numerically solving the Fokker-Planck equation. We show that the damping constant and anisotropy field can be extracted by measuring the full width half maximum of the switching time distribution in the magnetic nano-structure devices. Furthermore, the present method can be applied to not only single nano-structure, but also inhomogeneous nano-structure arrays.

Revisiting the Topographic Anatomy of the Marginal Mandibular Branch of Facial Nerve Relating to the Surgical Approach.

BACKGROUND: The marginal mandibular branch (Mbr) of the facial nerve is vulnerable to damage during rhytidoplasty, surgical reduction of the mandibular angle, parotidectomy, and excision of the submandibular gland. OBJECTIVES: The authors sought to map the Mbr and determine the relationship between the number of Mbr offshoots and the course of the Mbr. METHODS: The Mbr was examined in 29 hemifaces from 12 embalmed and 4 fresh cadavers (10 males, 6 females; mean age, 73.7 years). RESULTS: The Mbr was located ≤5 mm from the gonion (Go) in 24 of 29 hemifaces (82.8%) and ≤10 mm from the intersection of the facial artery and mandible (ie, FM) in 26 hemifaces (89.7%). In 16 hemifaces (55.2%), offshoots arose from the Mbr inferior to the mandible. The Mbr ran below the Go in 14 hemifaces (48.3%) and ran below FM in 13 hemifaces (44.8%). Except for minute offshoots deep to the platysma, the Mbr was not found to pass >2 cm below the mandible. The mean (± standard deviation) quantity of Mbr offshoots was 1.5 (± 0.6). A greater number of offshoots was associated with a higher likelihood of an inferiorly located nerve. The Mbr proceeded under the lower border of the mandible in 13 hemifaces (44.8%) and reached the mandible at a mean distance of 33.1±5.2 mm anterior to the Go. CONCLUSIONS: To avoid damaging the Mbr, surgical maneuvers should be positioned 4.5 cm anterior to the Go and 2 cm below the mandible.

Enhanced Nonadiabaticity in Vortex Cores due to the Emergent Hall Effect.

We present a combined theoretical and experimental study, investigating the origin of the enhanced nonadiabaticity of magnetic vortex cores. Scanning transmission x-ray microscopy is used to image the vortex core gyration dynamically to measure the nonadiabaticity with high precision, including a high confidence upper bound. We show theoretically, that the large nonadiabaticity parameter observed experimentally can be explained by the presence of local spin currents arising from a texture induced emergent Hall effect. This study demonstrates that the magnetic damping α and nonadiabaticity parameter ß are very sensitive to the topology of the magnetic textures, resulting in an enhanced ratio (ß/α>1) in magnetic vortex cores or Skyrmions.

Prediction of giant spin motive force due to Rashba spin-orbit coupling.

Magnetization dynamics in a ferromagnet can induce a spin-dependent electric field through a spin motive force. Spin current generated by the spin-dependent electric field can in turn modify the magnetization dynamics through spin-transfer torque. While this feedback effect is usually weak and thus ignored, we predict that in Rashba spin-orbit coupling systems with a large Rashba parameter α(R), the coupling generates the spin-dependent electric field [±(α(R)m(e)/eh)(z[over ^]×∂m/∂t)], which can be large enough to modify the magnetization dynamics significantly. This effect should be relevant for device applications based on ultrathin magnetic layers with strong Rashba spin-orbit coupling.

Clinical analysis of surgical approaches for orbital floor fractures.

OBJECTIVE: To identify the optimal surgical method for managing blowout fractures of the inferior orbital wall by analyzing the location and type of fracture based on computed tomographic findings and medical records. METHODS: Medical records of 102 patients with pure inferior blowout fractures who were treated between June 1996 and December 2005 were reviewed regarding fracture type and location and surgical approach. RESULTS: Ocular symptoms persisted in 14 of the 102 cases after surgery, and revision procedures were performed in 11 of those cases. Cases with persistent symptoms were analyzed in terms of fracture location and type of surgery. For anterior orbital floor fractures, symptoms persisted in 2 of the 4 cases treated using a transantral approach, while no symptoms persisted in any of the 15 cases treated using a transorbital approach or in either of the 2 cases treated using a combined approach. For posterior orbital floor fractures, symptoms persisted in 2 of the 31 cases treated using a transantral approach, in 4 of the 6 cases treated using a transorbital approach, and in 1 of the 19 cases treated using a combined approach. For anteroposterior orbital floor fractures, symptoms persisted in 2 of the 5 cases treated using a transorbital approach and in 3 of the 20 cases treated using transantral and combined approaches. CONCLUSION: Patients with large orbital floor fractures or posterior half fractures of the orbit should undergo surgery via a transantral or a combined approach, while patients with trapdoor fractures or anterior half fractures of the orbit should undergo surgery via a transorbital or a combined approach.

The differences of blowout fracture of the inferior orbital wall between children and adults.

OBJECTIVES: To review the clinical features and recovery period of patients with blowout fractures of the inferior orbital wall treated surgically and to examine the differences between children and adults. DESIGN: A retrospective study. SETTING: Department of Otorhinolaryngology, Maryknoll General Hospital, Busan, Korea. Patients Medical records of 70 patients were reviewed: 16 patients were children (aged <16 years) and 54 were adults (aged >or=17 years). MAIN OUTCOME MEASURES: Symptoms and fracture patterns were compared between both groups in all subjects, and the recovery period relative to the timing of surgery after the trauma was compared in subjects who complained of diplopia or extraocular limitation. RESULTS: Serious periorbital edema was noted in 43 adults (80%) and 4 children (25%), diplopia in 27 adults (50%) and 16 children (100%), and extraocular muscle limitation in 23 adults (43%) and 13 children (81%). Trapdoor fractures were frequent in the children group (n = 13; 81%), whereas 30 patients (56%) had open-door fractures in the adult group. In the children group, no differences in the recovery period relative to the timing of surgery was noted when all types of orbital fractures were considered. However, among the 13 children with trapdoor fractures, the recovery period was significantly shorter in those who underwent surgery 1 to 5 days after the trauma compared with those who underwent surgery after 6 to 14 days and 15 days or longer. In adults, the recovery period of those who underwent surgery 1 to 5 days and 6 to 14 days after the trauma were significantly shorter compared with those who underwent surgery after 15 days or longer. CONCLUSIONS: Diplopia, extraocular muscle limitation, and trapdoor fractures were more frequent in children than in adult patients. After trauma, surgical intervention might be required within 5 days in children with trapdoor fracture vs within 2 weeks in adults.