Interrelationships between exercise, functional connectivity, and cognition among healthy adults: A systematic review.

The main purpose of this systematic review was to examine past literature focusing on the potential relationship between exercise (or physical activity or cardiorespiratory fitness [CRF]) and functional brain connectivity in healthy adults. Among the studies meeting this purpose, we also evaluated studies investigating whether, and how, functional connectivity may influence the exercise-cognition relationship. A systematic review was employed through several electronic databases (PsychInfo, PubMed, and Google Scholar) in accordance with PRISMA guidelines. The literature search identified 656 records, and a total of 12 studies met the inclusion criteria. Among these 12 studies, there were 4, 7, and 1 study, respectively, examining the relationship between exercise and frontal lobe connectivity, temporal lobe connectivity, and whole-brain connectivity. Also, 7 studies examined the relationship between functional connectivity and cognitive performance across multiple brain regions as a function of exercise. Existing literature suggests that CRF, habitual physical activity, and varying intensities of acute exercise can strengthen functional connections among a wide variety of regions and subcortical structures of the human brain. These exercise-induced functional connectivity changes within and between specific brain structures/networks supporting cognitive processing may improve various domains of cognitive function. Given these complex associations, a thorough understanding of how functional connectivity plays a mediating role in the exercise-cognition interaction is needed in future studies.

Motor behavior-induced prefrontal cortex activation and episodic memory function.

BACKGROUND: The objective of this paper was to evaluate the potential individual and combined effects of acute exercise coupled with bilateral interhemispheric activation on episodic memory function. Six experiments were conducted. METHODS: Experiment 1 was a within-subject, counterbalanced experiment. Participants completed four visits, including 1) exercise and saccadic eye movements, 2) exercise only, 3) saccadic eye movements only, and 4) no exercise and no saccadic eye movements (control). A word-list memory assessment was employed, including a long-term (20-min delay) memory evaluation. In Experiment 2, we evaluated the effects of saccadic eye movements on prefrontal cortex oxygenation, a proxy for neuronal activity. Similarly, in our third experiment, we evaluated the effects of acute exercise on prefrontal cortex oxygenation. Thus, experiments 2 and 3 were employed to provide mechanistic insights from the results shown in experiment 1. Experiment 4 replicated Experiment 1, but instead of increasing prefrontal cortex activation via saccadic eye movements, we used a fist clenching protocol. Experiment 5 evaluated the effects of fist clenching on prefrontal cortex oxygenation. RESULTS: Collectively, these 5 experimental studies showed that acute exercise (Experiment 1), saccadic eye movements (Experiment 1), and fist clenching (Experiment 4) enhanced memory function, and that acute exercise (Experiment 3), saccadic eye movements (Experiment 2) and fist clenching (Experiment 5) all increased prefrontal cortex oxygenation. Experiment 6 demonstrated that prefrontal cortex oxygenation was positively associated with episodic memory function. CONCLUSION: These six experiments suggest that several behaviors, such as acute exercise, saccadic eye movements and fist clenching may improve memory function and may, potentially, do so via increases in prefrontal cortex oxygenation.

The association of self-reported physical activity on human sensory long-term potentiation.

Exercise has been shown to enhance synaptic plasticity, therefore, potentially affecting memory. While the mechanism(s) responsible for this relationship have been explored in animal models, current research suggests that exercise may possess the ability to induce synaptic long-term potentiation (LTP). Most of the LTP mechanistic work has been conducted in animal models using invasive procedures. For that reason, the purpose of the present experiment was to investigate whether self-reported exercise is related to human sensory LTP-like responses. Nineteen participants (MAGE = 24 years; 52.6% male) completed the study. Long-term potentiation-like responses were measured by incorporating a non-invasive method that assess the change in potentiation of the N1b component produced from the visual stimulus paradigm presented bilaterally in the visual field. Results demonstrated that those with higher levels of moderate-to-vigorous physical activity (MVPA) had a greater N1b change from baseline to the early time period assessment, r = -0.43, p = 0.06. Our findings provide some suggestive evidence of an association between self-reported MVPA and LTP-like responses. Additional work is needed to support that the potentiation of the human sensory N1b component in the observed study is due to the exercise-induced synaptic changes similar to that detailed in prior animal research.

The Impact of a Dried Fruit and Vegetable Supplement and Fiber Rich Shake on Gut and Health Parameters in Female Healthcare Workers: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial.

Aim: Phytochemicals from fruits and vegetables are known to reduce inflammation and improve overall health. The objective of this study was to determine the effect of a fruit and vegetable concentrate (FVC) and high fiber component on the gut microbiome in an overweight/obese, female population. Methods: The study was a randomized, double blind, placebo-controlled trial with 57 asymptomatic, pre-menopausal, overweight/obese females between 25-50 years of age working in healthcare. Blood and fecal samples were collected before and after two, four and five months of daily supplementation. Metabolic parameters were measured, and the gut microbiome analyzed. Results: No effect was observed with FVC supplementation for blood lipids, glucose and immune parameters. There was an improvement in glucose clearance. The FVC supplement did not result in taxonomic alterations at phyla level, or changes in α or ß diversity, but reduced Bacteroides abundance and increased fecal butyrate. An additional high fiber component improved levels of health associated bacteria. Conclusion: The results suggest that a dried fruit and vegetable supplement, with a high fiber meal replacement can alter the intestinal microbiota and improve glucose clearance, suggesting that this combination of supplements can improve glucose metabolism and possibly reduce the risk of insulin resistance.

Exercise influences episodic memory via changes in hippocampal neurocircuitry and long-term potentiation.

The ability to learn, store and recapture information about unique personal experiences is referred to as episodic memory and is sustained by a network of brain areas that are nestled within the medial temporal lobe (MTL) and associated networks. Human and animal data demonstrate that these structural components are influential in the organization and processing of incoming information. Strengthening the cellular and neural communication within the aforementioned components of the brain, called long-term potentiation (LTP), is considered a driving force underscoring the ability to recapture information about unique personal experiences. This process can be enhanced by exercise, thus facilitating improvements in episodic memory. This narrative review discusses the interrelationships (and underlying mechanisms) between exercise, LTP and episodic memory.

A SYSTEMATIC REVIEW AND META-ANALYSIS OF COMMON THERAPEUTIC EXERCISES THAT GENERATE HIGHEST MUSCLE ACTIVITY IN THE GLUTEUS MEDIUS AND GLUTEUS MINIMUS SEGMENTS.

BACKGROUND: The gluteus medius (GMed) and gluteus minimus (GMin) muscle segments demonstrate different responses to pathology and ageing, hence it is important in rehabilitation that prescribed therapeutic exercises can effectively target the individual segments with adequate exercise intensity for strengthening. PURPOSE: The purpose of this systematic review was to evaluate whether common therapeutic exercises generate at least high ( > 40% maximum voluntary isometric contraction (MVIC)) electromyographic (EMG) activity in the GMed (anterior, middle and posterior) and GMin (anterior and posterior) segments. METHODS: Seven databases (MEDLINE, EMBASE, CINAHL, AusSPORT, PEDro, SPORTdiscus and Cochrane Library) were searched from inception to May 2018 for terms relating to gluteal muscle, exercise, and EMG. The search yielded 6918 records with 56 suitable for inclusion. Quality assessment, data extraction and data analysis were then undertaken with exercise data pooled into a meta-analysis where two or more studies were available for an exercise and muscle segment. RESULTS: For the GMed, different variations of the hip hitch/ pelvic drop exercise generated at least high activity in all segments. The dip test, and isometric standing hip abduction are other options to target the anterior GMed segment, while isometric standing hip abduction can be used for the posterior GMed segment. For the middle GMed segment, the single leg bridge; side-lying hip abduction with hip internal rotation; lateral step-up; standing hip abduction on stance or swing leg with added resistance; and resisted side-step were the best options for generating at least high activity. Standing isometric hip abduction and different variations of the hip hitch/ pelvic drop exercise generated at least high activity in all GMin segments, while side-lying hip abduction, the dip test, single leg bridge and single leg squat can also be used for targeting the posterior GMin segment. CONCLUSION: The findings from this review provide the clinician with confidence in exercise prescription for targeting individual GMed and GMin segments for potential strengthening following injury or ageing. LEVEL OF EVIDENCE: Level 1. WHAT IS KNOWN ABOUT THE SUBJECT: Previous reviews on GMed exercises have been based on single electrode, surface EMG measures at middle GMed segment. It is not known whether these exercises effectively target the other segments of GMed or the GMin at a sufficient intensity for strengthening. WHAT THIS STUDY ADDS TO EXISTING KNOWLEDGE: This review provides the clinician with confidence in exercise prescription of common therapeutic exercises to effectively target individual GMed and GMin segments for potential strengthening.

Does Aerobic and Resistance Exercise Influence Episodic Memory through Unique Mechanisms?

Aerobic and resistance exercise (acute and chronic) independently and collectively induce beneficial responses in the brain that may influence memory function, including an increase in cerebral blood flow, neurogenesis, neuroelectrical alterations, and protein production. However, whether aerobic and resistance exercise improve memory via similar or distinct mechanisms has yet to be fully explained. Here, we review the unique influence of aerobic and resistance exercise on neural modulation, proteins, receptors, and ultimately, episodic memory. Resistance training may optimize neural communication, information processing and memory encoding by affecting the allocation of attentional resources. Moreover, resistance exercise can reduce inflammatory markers associated with neural communication while increasing peripheral and central BDNF (brain-derived neurotrophic factor) production. Aerobic training increases hippocampal levels of BDNF and TrkB (Tropomyosin receptor kinase B), protein kinases and glutamatergic proteins. Likewise, both aerobic and anaerobic exercise can increase CREB (cAMP response element-binding protein) phosphorylation. Thus, we suggest that aerobic and resistance exercise may influence episodic memory via similar and, potentially, distinct mechanisms.

The Effects of Human Visual Sensory Stimuli on N1b Amplitude: An EEG Study.

Sensory systems are widely known to exhibit adaptive mechanisms. Vision is no exception to input dependent changes in its sensitivity. Recent animal work demonstrates enhanced connectivity between neurons in the visual cortex. The purpose of the present experiment was to evaluate a human model that noninvasively alters the amplitude of the N1b component in the visual cortex of humans by means of rapid visual stimulation. Nineteen participants (Mage = 24 years; 52.6% male) completed a rapid visual stimulation paradigm involving black and white reversal checkerboards presented bilaterally in the visual field. EEG data was collected during the visual stimulation paradigm, which consisted of four main phases, a pre-tetanus block, photic stimulus, early post-tetanus, and late post-tetanus. The amplitude of the N1b component of the pre-tetanus, early post-tetanus and late post-tetanus visual evoked potentials were calculated. Change in N1b amplitude was calculated by subtracting pre-tetanus N1b amplitude from early and late post-tetanus. Results demonstrated a significant difference between pre-tetanus N1b (M = -0.498 µV, SD = 0.858) and early N1b (M = -1.011 µV, SD = 1.088), t (18) = 2.761, p = 0.039, d = 0.633. No difference was observed between pre-tetanus N1b and late N1b (p = 0.36). In conclusion, our findings suggest that it is possible to induce changes in the amplitude of the visually evoked potential N1b waveform in the visual cortex of humans non-invasively. Additional work is needed to corroborate that the potentiation of the N1b component observed in this study is due to similar mechanisms essential to prolonged strengthened neural connections exhibited in cognitive structures of the brain observed in prior animal research. If so, this will allow for the examination of strengthened neural connectivity and its interaction with multiple human sensory stimuli and behaviors.

Tai Chi Training Evokes Significant Changes in Brain White Matter Network in Older Women.

Background: Cognitive decline is age relevant and it can start as early as middle age. The decline becomes more obvious among older adults, which is highly associated with increased risk of developing dementia (e.g., Alzheimer's disease). White matter damage was found to be related to cognitive decline through aging. The purpose of the current study was to compare the effects of Tai Chi (TC) versus walking on the brain white matter network among Chinese elderly women. Methods: A cross-sectional study was conducted where 42 healthy elderly women were included. Tai Chi practitioners (20 females, average age: 62.9 ± 2.38 years, education level 9.05 ± 1.8 years) and the matched walking participants (22 females, average age: 63.27 ± 3.58 years, educational level: 8.86 ± 2.74 years) underwent resting-state functional magnetic resonance imaging (rsfMRI) scans. Diffusion tensor imaging (DTI) and graph theory were employed to study the data, construct the white matter matrix, and compare the brain network attributes between the two groups. Results: Results from graph-based analyses showed that the small-world attributes were higher for the TC group than for the walking group (p < 0.05, Cohen's d = 1.534). Some effects were significant (p < 0.001) with very large effect sizes. Meanwhile, the aggregation coefficient and local efficiency attributes were also higher for the TC group than for the walking group (p > 0.05). However, no significant difference was found between the two groups in node attributes and edge analysis. Conclusion: Regular TC training is more conducive to optimize the brain functioning and networking of the elderly. The results of the current study help to identify the mechanisms underlying the cognitive protective effects of TC.

Rehabilitation Exercises for the Gluteus Medius Muscle Segments: An Electromyography Study.

CONTEXT: Many different rehabilitation exercises have been recommended in the literature to target the gluteus medius (GMed) muscle based mainly on single-electrode, surface electromyography (EMG) measures. With the GMed consisting of 3 structurally and functionally independent segments, there is uncertainty on whether these exercises will target the individual segments effectively. OBJECTIVE: To measure individual GMed segmental activity during 6 common, lower-limb rehabilitation exercises in healthy young adults, and determine if there are significant differences between the exercises for each segment. METHOD: With fine-wire EMG electrodes inserted into the anterior, middle, and posterior segments of the GMed muscle, 10 healthy young adults performed 6 common, lower-limb rehabilitation exercises. MAIN OUTCOME MEASURES: Recorded EMG activity was normalized, then reported and compared with median activity for each of the GMed segments across the 6 exercises. RESULTS: For the anterior GMed segment, high activity was recorded for the single-leg squat (48% maximum voluntary isometric contraction [MVIC]), the single-leg bridge (44% MVIC), and the resisted hip abduction-extension exercise (41% MVIC). No exercises recorded high activity for the middle GMed segment, but for the posterior GMed segment very high activity was recorded by the resisted hip abduction-extension exercise (69% MVIC), and high activity was generated by the single-leg squat (48% MVIC) and side-lie hip abduction (43% MVIC). For each of the GMed segments, there were significant differences (P < .05) in the median EMG activity levels between some of the exercises and the side-lie clam with large effect sizes favoring these exercises over the side-lie clam. CONCLUSIONS: Open-chain hip abduction and single-limb support exercises appear to be effective options for recruiting the individual GMed segments with selection dependent on individual requirements. However, the side-lie clam does not appear to be effective at recruiting the GMed segments, particularly the anterior and middle segments.

Rehabilitation Exercises for the Gluteus Minimus Muscle Segments: An Electromyography Study.

CONTEXT: The gluteus minimus (GMin) muscle consists of 2 uniquely oriented segments that have potential for independent function and have different responses to pathology and aging. For healthy young adults, it is unknown that which rehabilitation exercises specifically target the individual segments. OBJECTIVE: To quantify segmental GMin activity for 6 common lower-limb rehabilitation exercises in healthy young adults and determine if significant differences exist in segmental activity levels between the exercises. METHOD: Six common lower-limb rehabilitation exercises were performed by 10 healthy young adults with fine-wire electromyography (EMG) electrodes inserted into the anterior and posterior segments of the GMin muscle. MAIN OUTCOME MEASURES: Electromyography signals were recorded, and median normalized exercise activity levels were reported and compared for each GMin segment across the 6 exercises. RESULTS: High activity levels were generated in the anterior segment by the resisted hip abduction-extension exercise (51% maximum voluntary isometric contraction [MVIC]), whereas for the posterior segment, high activity levels were produced by the single-leg bridge (49% MVIC), the side-lie hip abduction (43% MVIC), the resisted hip abduction-extension exercise (43% MVIC), and the single-leg squat (40% MVIC). There were significant differences (P < .05) in the median electromyography activity levels for the anterior GMin segment but not for the posterior GMin segment across some of the exercises with large effect sizes. CONCLUSION: Targeted rehabilitation exercises graded by exercise intensity can be prescribed specifically for the anterior and posterior GMin segments to aid in restoration of hip function following injury or aging.