RESUMO
Monkeypox is a zoonosis that re-emerged in 2022, generating cases in non-endemic countries for the disease and creating a public health issue. The rapid increase in the number of cases kindles a need for quick, inexpensive diagnostic tests for the epidemiological control of the disease. The high cost of molecular tests can make this control more difficult to access in poorer regions, with immunological tests being a more viable option. In this mini-review, a search was conducted in the main databases for peptide and protein options that could be used in the development of serological diagnostic tests. Nine viable registres were found, and seven were selected (two patents and five studies). The main studies used the B21R peptide sequence as it is a high immunogenic epitope. In addition, studies on the improvement of these sequences were also found to avoid cross-reactions against other viruses of the same family, proposing a rational approach using multiepitope recombinant proteins. These approaches demonstrated high sensitivity and specificity values and are seen as viable options for developing new tests. New effective serological testing options, when combined with awareness, disease surveillance, early diagnosis, and rapid communication, form a set of key strategies used by health systems to control the spread of the monkeypox virus.
Assuntos
Mpox , Humanos , Mpox/epidemiologia , Peptídeos , Sequência de Aminoácidos , Proteínas Recombinantes , Testes SorológicosRESUMO
A tecnologia tem se difundido gradativamente em todas as esferas da sociedade, se estabelecendo como indispensável. No âmbito da educação não é diferente, ela vem abrindo novas portas para o desenvolvimento do conhecimento. O presente trabalho tem como objetivo descrever a, elaboração de uma plataforma multimídia sobre gênese dental e as possíveis alterações dento-alveolares que dela se originam, para que os estudantestenham uma visão ampliada, dinâmica e interdisciplinar deste conhecimento. Como referencial teórico foram utilizados livros que servem como base no ensino da odontologia, além de buscas de artigos científicos nas bases de dados Scielo, PubMed, Periódicos CAPES, e em outras fontes de informação, como o Google Acadêmico. Para a elaboração do instrumento foi utilizado o sistema Flash + ActionScript 3 (AS3) na plataforma Adobe AIR, permitindo ao aluno a navegação em todas as fases formativas do elemento dentário à medida que clicarem no ambiente desejado. A interdisciplinaridade e interatividade dos assuntos permitidos por esta plataforma oportunizará ao discente a construir um conhecimento de alta relevância na odontologia, servindo de instrumento didático dentro da nova tendência do ensino que, consequentemente, ajudará no raciocínio da investigação do diagnóstico (AU).
Technology has gradually spread over all fields of society, becoming indispensable and promoting evolution. The same way it has opened a completely new world of possibilities for the development of knowledge in education. This work presents a new software conceived as a tool for either undergraduate or graduate dental students to provide them a thorough, dynamic and interdisciplinary vision of dental genesis, as well as the possible changes in dentoalveolar structures during the developmental process of teeth germs. It referred to scientific material from books adopted in Dentistry education, articles from Scielo, Pubmed and Periodicals CAPES databases and other information accessed by search tools such as Google Scholar and similar ones. The dynamic process was accomplished by using the Flash + Action Script 3 (AS3) system in Adobe AIR platform, allowing students to navigate throughout all the developmental phases of teeth germs by clicking on desired file. The interdisciplinarity and interactivity of information made possible with this platform allows students to build up highly importance knowledge in Dentistry, as it works as a didactic instrument in accordance to the new teaching tendency, which will consequently help in diagnostic reasoning (AU).