Relationship between Obesity and Coronary Artery Disease Defined by Coronary Computed Tomography Angiography

Abstract Background: Although associated with traditional cardiovascular risk factors, it is unclear whether obesity alone is associated with coronary artery disease (CAD). Objective: To investigate the role of obesity as a risk factor for CAD, defined by coronary computed tomography angiography (CCTA). Methods: This study retrospectively included 1,814 patients referred for CCTA in a hospital in São Paulo, from August 2010 to July 2012. CAD was identified by coronary calcium score and presence of coronary stenosis > 50%. Images were analyzed by two specialists, and the coronary findings were compared between obese and non-obese groups. A multivariate analysis model was used to assess obesity as an independent variable for the occurrence of obstructive CAD. Results: Among the study population, mean age was 58.5 +/- 11.5 years, 22.8% were obese (BMI = 30 kg/m2) and 66.3% were male. The prevalence of obstructive CAD was 18.4% in both groups. Obese patients had higher median calcium score compared to non-obese subjects (14.7 vs. 1.4, respectively, p = 0.019). In the multivariate analysis, obesity was not an independent factor for obstructive CAD (coefficient = -0.035, p = 0.102). Conclusion: Although no differences were observed in the prevalence of obstructive CAD between obese and non-obese individuals, coronary calcium scores were significantly in lower the latter group.

Abscesso de corpo cavernoso por Candida Albicans: relato de caso / Abscess of corpus cavernosum caused by Candida Albicans: case report

O abscesso de corpo cavernoso é uma condição bastante rara. Geralmente ocorre devido complicações de trauma, terapia de injeção intracavernosa, cavernosografia, corpos estranhos ou comorbidades, como por exemplo diabetes. Os diabéticos constituem grupo de risco devido à microangiopatia e imunossupressão. Neste relato é descrito o caso de um paciente diabético com aparecimento de abscesso em corpo cavernoso após introdução de corpo estranho em meato uretral. Após a drenagem cirúrgica do abscesso, foi verificado o crescimento de Candida albicans na cultura no material coletado, possibilitando direcionar o tratamento com antibiótico

Corpus cavernosum abscess is a rare condition. It usually occurs due to complications of trauma, intracavernous injection therapy, angiography of the corpus cavernosum, foreign bodies or comorbidities, such as diabetes. Diabetic people constitute a risk group due to microangiopathy and immunosuppression. In this case report is described a case of a diabetic patient with abscess of corpus cavernosum after introduction of foreign body into the urethral meatus. After the surgical drainage of the abscess was verified in the culture of collected material Candida albicans, allowing to direct the antibiotic treatment