RESUMO
Specific IgG and IgM responses to soluble egg antigen (SEA) and keyhole limpet haemocyanin (KLH) were measured by ELISA in patients with acute and chronic schistosomiasis. The tests based upon IgM and IgG antibodies responses to KLH presented the best diagnostic discrimination, and can be used in conjunction with clinical and epidemiological data to the differential diagnosis of acute schistosomiasis.
Assuntos
Antígenos de Helmintos/sangue , Proteínas de Helminto/sangue , Hemocianinas/imunologia , Schistosoma mansoni/imunologia , Esquistossomose mansoni/diagnóstico , Doença Aguda , Animais , Anticorpos Anti-Helmínticos/imunologia , Biomarcadores/sangue , Doença Crônica , Ensaio de Imunoadsorção Enzimática , Hemocianinas/análise , Humanos , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Esquistossomose mansoni/sangue , Sensibilidade e EspecificidadeRESUMO
Specific IgG and IgM responses to soluble egg antigen (SEA) and keyhole limpet haemocyanin (KLH) were measured by ELISA in patients with acute and chronic schistosomiasis. The tests based upon IgM and IgG antibodies responses to KLH presented the best diagnostic discrimination, and can be used in conjunction with clinical and epidemiological data to the differential diagnosis of acute schistosomiasis.
Assuntos
Humanos , Animais , Antígenos de Helmintos , Schistosoma mansoni , Esquistossomose mansoni , Doença Aguda , Anticorpos Anti-Helmínticos , Biomarcadores , Doença Crônica , Ensaio de Imunoadsorção Enzimática , Imunoglobulina G , Imunoglobulina M , Sensibilidade e EspecificidadeRESUMO
The production and regulation of interleukin (IL) IL-13, IL-4 and interferon-gamma was evaluated in different clinical forms of human schistosomiasis. The mechanisms of immune regulation are apparently different in the various clinical stages of the disease, some of them being antigen specific
