Influence of Flavonoid-Rich Fraction of Monodora tenuifolia Seed Extract on Blood Biochemical Parameters in Streptozotocin-Induced Diabetes Mellitus in Male Wistar Rats.

Diabetes mellitus is a metabolic disorder caused by either the total destruction of the pancreatic beta cells that secrete insulin for the uptake of glucose from the circulation or as a result of the inability of body cells to respond to the presence of insulin in the blood. The present study investigated the effect of a flavonoid-rich fraction of Monodora tenuifolia seed extract (FFMTSE) on blood parameters in streptozotocin (STZ)-induced diabetic male Wistar rats. The rats were divided into seven groups (n = 6). Group 1: normal control rats, Group 2: rats + FFMTSE (25 mg/kgbwt), Group 3: rats + FFMTSE (50 mg/kgbwt), Group 4: diabetic control rats, Group 5: diabetic rats + FFMTSE (25 mg/kgbwt), Group 6: diabetic rats + FFMTSE (50 mg/kgbwt), and Group 7: diabetic rats + Metformin. The assessment of the lipid profile, kidney functions (urea and creatinine), and cardiac biomarkers (LDH and CK-MB) were carried out in the plasma using established protocols. The results showed a significant increase in the concentrations of triacylglycerol, cholesterol, LDL-cholesterol, VLDL-cholesterol, urea, and creatinine, as well as in cardiac enzyme activities in diabetic rats. However, the administration of the FFMTSE significantly improved the observed biochemical parameters. In addition, an increased concentration of HDL-cholesterol concentration was observed in the diabetic rats upon treatment with FFMTSE. These findings indicate that FFMTSE could be a potent anti-nephropathy and anti-cardiomyopathy agent in diabetic conditions.

Dataset on theoretical bio-evaluation of 1,2,4-thiadiazole-1,2,4-triazole analogues against epidermal growth factor receptor kinase down regulating human lung cancer.

Data from eight 1,2,4-thiadiazole-1,2,4-triazole derivatives were used to observe the anti-epidermal growth factor receptor kinase activities of 1,2,4-thiadiazole-1,2,4-triazole analogues thereby reducing human lung cancer. The software used to achieve this work were Spartan 14, Pymol, mgltools_win32_1.5.6, Auto dock vina and biovia2019.ds2019client. Also, the developed QSAR model was developed using the screened descriptors so as to inspect the closeness between the experimental IC50 and the predicted IC50. More so, the binding affinity from 1,2,4-thiadiazole-1,2,4-triazole derivatives - epidermal growth factor receptor kinase complexes using molecular docking approach were reported. Also, the ADMET properties for selected compounds and proposed compounds with better binding affinity were reported.