Microbiome-induced Increases and Decreases in Bone Tissue Strength can be Initiated After Skeletal Maturity.

Recent studies in mice have indicated that the gut microbiome can regulate bone tissue strength. However, prior work involved modifications to the gut microbiome in growing animals and it is unclear if the same changes in the microbiome, applied later in life, would change matrix strength. Here we changed the composition of the gut microbiome before and/or after skeletal maturity (16 weeks of age) using oral antibiotics (ampicillin + neomycin). Male and female mice (n=143 total, n=12-17/group/sex) were allocated into five study groups:1) Unaltered, 2) Continuous (dosing 4-24 weeks of age), 3) Delayed (dosing only 16-24 weeks of age), 4) Initial (dosing 4-16 weeks of age, suspended at 16 weeks), and 5) Reconstituted (dosing from 4-16 weeks following by fecal microbiota transplant from Unaltered donors). Animals were euthanized at 24 weeks of age. In males, bone matrix strength in the femur was 25-35% less than expected from geometry in mice from the Continuous (p= 0.001), Delayed (p= 0.005), and Initial (p=0.040) groups as compared to Unaltered. Reconstitution of the gut microbiota, however, led to a bone matrix strength similar to Unaltered animals (p=0.929). In females, microbiome-induced changes in bone matrix strength followed the same trend as males but were not significantly different, demonstrating sex-related differences in the response of bone matrix to the gut microbiota. Minor differences in chemical composition of bone matrix were observed (Raman spectroscopy). Our findings indicate that microbiome-induced impairment of bone matrix in males can be initiated and/or reversed after skeletal maturity. The portion of the femoral cortical bone formed after skeletal maturity (16 weeks) is small; however, this suggests that microbiome-induced changes in bone matrix occur without osteoblast/osteoclast turnover using an, as of yet unidentified mechanism. These findings add to evidence that the mechanical properties of bone matrix can be altered in the adult skeleton.

Spin-Orbit and Zeeman Effects on the Electronic Properties of Single Quantum Rings: Applied Magnetic Field and Topological Defects.

Within the framework of effective mass theory, we investigate the effects of spin-orbit interaction (SOI) and Zeeman splitting on the electronic properties of an electron confined in GaAs single quantum rings. Energies and envelope wavefunctions in the system are determined by solving the Schrödinger equation via the finite element method. First, we consider an inversely quadratic model potential to describe electron confining profiles in a single quantum ring. The study also analyzes the influence of applied electric and magnetic fields. Solutions for eigenstates are then used to evaluate the linear inter-state light absorption coefficient through the corresponding resonant transition energies and electric dipole matrix moment elements, assuming circular polarization for the incident radiation. Results show that both SOI effects and Zeeman splitting reduce the absorption intensity for the considered transitions compared to the case when these interactions are absent. In addition, the magnitude and position of the resonant peaks have non-monotonic behavior with external magnetic fields. Secondly, we investigate the electronic and optical properties of the electron confined in the quantum ring with a topological defect in the structure; the results show that the crossings in the energy curves as a function of the magnetic field are eliminated, and, therefore, an improvement in transition energies occurs. In addition, the dipole matrix moments present a non-oscillatory behavior compared to the case when a topological defect is not considered.

Optical Properties in a ZnS/CdS/ZnS Core/Shell/Shell Spherical Quantum Dot: Electric and Magnetic Field and Donor Impurity Effects.

A theoretical analysis of optical properties in a ZnS/CdS/ZnS core/shell/shell spherical quantum dot was carried out within the effective mass approximation. The corresponding Schrödinger equation was solved using the finite element method via the 2D axis-symmetric module of COMSOL-Multiphysics software. Calculations included variations of internal dot radius, the application of electric and magnetic fields (both oriented along z-direction), as well as the presence of on-center donor impurity. Reported optical properties are the absorption and relative refractive index change coefficients. These quantities are related to transitions between the ground and first excited states, with linearly polarized incident radiation along the z-axis. It is found that transition energy decreases with the growth of internal radius, thus causing the red-shift of resonant peaks. The same happens when the external magnetic field increases. When the strength of applied electric field is increased, the opposite effect is observed, since there is a blue-shift of resonances. However, dipole matrix moments decrease drastically with the increase of the electric field, leading to a reduction in amplitude of optical responses. At the moment impurity effects are activated, a decrease in the value of the energies is noted, significantly affecting the ground state, which is more evident for small internal radius. This is reflected in an increase in transition energies.

Electronic structure of vertically coupled quantum dot-ring heterostructures under applied electromagnetic probes. A finite-element approach.

We theoretically investigate the electron and hole states in a semiconductor quantum dot-quantum ring coupled structure, inspired by the recent experimental report by Elborg and collaborators (2017). The finite element method constitutes the numerical technique used to solve the three-dimensional effective mass equation within the parabolic band approximation, including the effects of externally applied electric and magnetic fields. Initially, the features of conduction electron states in the proposed system appear discussed in detail, under different geometrical configurations and values of the intensity of the aforementioned electromagnetic probes. In the second part, the properties of an electron-hole pair confined within the very kind of structure reported in the reference above are investigated via a model that tries to reproduce as close as possible the developed profile. In accordance, we report on the energies of confined electron and hole, affected by the influence of an external electric field, revealing the possibility of field-induced separate spatial localization, which may result in an indirect exciton configuration. In relation with this fact, we present a preliminary analysis of such phenomenon via the calculation of the Coulomb integral.

Magnetoconductivity in quasiperiodic graphene superlattices.

The magnetoconductivity in Fibonacci graphene superlattices is investigated in a perpendicular magnetic field B. It was shown that the B-dependence of the diffusive conductivity exhibits a complicated oscillatory behavior whose characteristics cannot be associated with Weiss oscillations, but rather with Shubnikov-de Haas ones. The absense of Weiss oscillations is attributed to the existence of two incommensurate periods in Fibonacci superlattices. It was also found that the quasiperiodicity of the structure leads to a renormalization of the Fermi velocity [Formula: see text] of graphene. Our calculations revealed that, for weak B, the dc Hall conductivity [Formula: see text] exhibits well defined and robust plateaux, where it takes the unexpected values [Formula: see text], indicating that the half-integer quantum Hall effect does not occur in the considered structure. It was finally shown that [Formula: see text] displays self-similarity for magnetic fields related by [Formula: see text] and [Formula: see text], where [Formula: see text] is the golden mean.

Pyramidal core-shell quantum dot under applied electric and magnetic fields.

We have theoretically investigated the electronic states in a core/shell pyramidal quantum dot with GaAs core embedded in AlGaAs matrix. This system has a quite similar recent experimental realization through a cone/shell structure [Phys. Status Solidi-RRL 13, 1800245 (2018)]. The research has been performed within the effective mass approximation taking into account position-dependent effective masses and the presence of external electric and magnetic fields. For the numerical solution of the resulting three-dimensional partial differential equation we have used a finite element method. A detailed study of the conduction band states wave functions and their associated energy levels is presented, with the analysis of the effect of the geometry and the external probes. The calculation of the non-permanent electric polarization via the off-diagonal intraband dipole moment matrix elements allows to consider the related optical response by evaluating the coefficients of light absorption and relative refractive index changes, under different applied magnetic field configurations.

Donor impurity energy and optical absorption in spherical sector quantum dots.

The properties of the conduction band energy states of an electron interacting with a donor impurity center in spherical sector-shaped GaAs-Al0.3Ga0.7As quantum dots are theoretically investigated. The study is performed within the framework of the effective mass approximation through the numerical solution of the 3D Schrödinger equation for the envelope function via the finite element method. The modifications undergone by the spectrum due to the changes in the conical structure geometry (radius and apical angle) as well as in the position of the donor atom are discussed. With the information regarding electron states the linear optical absorption coefficient associated with transition between confined energy levels is evaluated and its features are discussed. The comparison of results obtained within the considered model with available experimental data in GaAs truncated-whisker-like quantum dots shows very good agreement. Besides, our simulation leads to identify the lowest energy photoluminescence peak as donor-related, instead of being associated to acceptor atoms, as claimed after experimental measurement (Hiruma et al. (1995) [14]). Also, a checking of our numerical approach is performed by comparing with analytical solutions to the problem of a spherical cone-shaped GaN with infinite confinement and donor impurity located at the cone apex. Coincidence is found to be remarkable.

Electronic states in GaAs-(Al,Ga)As eccentric quantum rings under nonresonant intense laser and magnetic fields.

The features of the electron energy spectrum in eccentric two-dimensional GaAs-AlGaAs quantum rings of circular shape are theoretically investigated taking into account the effect of externally applied magnetic and intense laser fields. Analytical expressions for the laser-dressed confining potential in this kind of quantum ring geometry are reported for the first time. Finite element method is used to solve the resulting single-particle effective mass two-dimensional partial differential equation. It is shown that the allowed level spectrum is greatly influence by the external probe as well as by the breaking of geometric symmetry related to the changes in eccentricity. In presence of an intense laser field, the conduction band confining profile suffers strong modifications along the structure, with an additional contribution to symmetry breaking. These modifications of electronic quantum states reflect in the intraband optical absorption. Accordingly, the features of the intraband transitions are discussed in detail, revealing the significant influence of the magnetic field strength and laser field intensity and polarization, together with eccentricity, in the allowing of ground-to-excited states transitions and their corresponding intensities.

Effects of Geometry on the Electronic Properties of Semiconductor Elliptical Quantum Rings.

The electronic states in GaAs-AlxGa1-xAs elliptically-shaped quantum rings are theoretically investigated through the numerical solution of the effective mass band equation via the finite element method. The results are obtained for different sizes and geometries, including the possibility of a number of hill-shaped deformations that play the role of either connected or isolated quantum dots (hills), depending on the configuration chosen. The quantum ring transversal section is assumed to exhibit three different geometrical symmetries - squared, triangular and parabolic. The behavior of the allowed confined states as functions of the cross-section shape, the ring dimensions, and the number of hills-like structures are discussed in detail. The effective energy bandgap (photoluminescence peak with electron-hole correlation) is reported as well, as a function of the Al molar fraction.

Electron Raman Scattering and Raman Gain in Pyramidal Semiconductor Quantum Dots.

The Raman scattering related with conduction band states in semiconductor pyramidal quantum dots is theoretically investigated. The electron Raman differential cross section and Raman gain coefficient are calculated making use of analytically determined quantum states. The energy spectrum is obtained within the effective mass approximation. The features of the Raman differential cross section are discussed in terms of their dependence on the changes of the quantum dot geometry. The variation of the Raman gain coefficient as a function of the quantum dot size and shape is also analyzed.

Adaptación de una cepa compatible con Acidithiobacillus ferrooxidans sobre concentrados de calcopirita (CuFeS2), esfalerita (ZnS) y galena (PbS) / Adaptation of a strain Acidithiobacillus ferrooxidans compatible on concentrates of chalcopyrite (CuFeS2), sphalerite (ZnS) and galena (PbS)

En este estudio se evaluó la adaptación de una cepa compatible con Acidithiobacillus ferrooxidans a altas densidades de pulpa de calcopirita, esfalerita y galena, con dos distribuciones de tamaño de partícula, -200 y -325 serie Tyler de tamices. Los microorganismos fueron adaptados por la disminución gradual de la fuente principal de energía, sulfato ferroso, y el aumento en el contenido de mineral, para finalmente realizar un subcultivo sin la adición de fuente de energía externa. La realización de subcultivos en serie resultó ser una estrategia eficaz para la adaptación a altas densidades de pulpa de esfalerita, calcopirita y galena indicando que el protocolo empleado es adecuado. Los resultados muestran que la cepa compatible con Acidithiobacillus ferrooxidans es más resistente a altas concentraciones de esfalerita, seguido por calcopirita y finalmente por galena. El tamaño de partícula juega un papel fundamental en la adaptación de los microorganismos al mineral.

In this study the adaptation of Acidithiobacillus ferrooxidans-like to high concentrations of chalcopyrite, sphalerite and galena were evaluated with two mineral-particle sizes: 200 and 325 Tyler mesh. The strain was adapted using two simultaneous processes. The first one consisted in a gradual decreasing of the main energy source, ferrous sulphate. The second one consisted in a gradual increasing of the mineral content. Finally, a test was made without ferrous sulphate. The serial subculturing was found to be an efficient strategy to adapt Acidithiobacillus ferrooxidans-like to higher concentrations of chalcopyrite, sphalerite and galena. This indicates that a suitable protocol was employed. The results showed that Acidithiobacillus ferrooxidans-like is more resistant to high concentration of sphalerite, chalcopyrite and galena in descendant order. The particle size played an important role in the adaption of microorganism to the mineral.

Histiocitoma fibroso maligno pleomórficocutáneo de rápido crecimiento / Cutaneous pleomorphic malignant fibrous histiocytoma with a rapidly growing

El histiocitoma fibroso maligno es un sarcoma de partes blandas, de presentación preferente entre la cuarta y quinta década de la vida, localizándoseprincipalmente en la zona proximal de extremidades inferiores. Histológicamente existen varios tipos según la morfología celular del tumor: la formapleomórfica, estoriforme (predominando los fibroblastos o los histiocitos como células dominantes), mixoide, de células gigantes e inflamatorio.La forma clínica más frecuente de presentación es como lesión tumoral profunda, localizada en el músculo esquelético, que puede protuir la piel que larecubre.Comentamos el caso de un varón de 81 años que consultó por una tumoración cutánea asintomática, de gran tamaño y rápido crecimiento (siete meses),localizado en pared torácica izquierda. Histológicamente el tumor mostraba un patrón típicamente estoriforme, formado por histiocitos y fibroblastos atípicos.Las células fueron positivas para vimentina, lisozima y CD68, hallazgos compatibles, con un histiocitoma fibroso maligno pleomórfico.Se revisan las características clínico patológicas y citogenéticas de este tumor, así como las distintas opciones terapéuticas (AU)

Malignant fibrous histiocytoma,(MFH) is the most common soft-part sarcoma arising between the fourth an fifth decades of life, that usually involvesthe proximal lower extremities. Its histology has shown a wide variety of cell morphology, including storiform-pleomophic (fibroblastic or histiocyticcells dominant), myxoid, giant cell and inflammatory types. The most usual presentation is a tumoral lesion located within skeletal muscle that mayspread to the skin as a painless nodule.We report a 82-years-old man who was seen with 7-month history of a rapidly growing and asynthomatic tumour of the left flank. Histologically thetumor showed a typical storiform pattern consisting of atypical histiocytic and fibroblastic cells. The cells were positive for vimentina, lisozima andCD68. These findings were compatible with a pleomorphic malignant fibrous histiocytoma.We review the clinical manifestations, histological findings and histogenesis of this tumour, and the different therapeutical options (AU)

Penfigo crónico familiar benigno (enfermedad de Hailey-Hailey). A propósito de un caso / Familial benign chronic pemphigus (Hailey-Hailey disease). Report of a case

La enfermedad de Hailey-Hailey (pénfigo crónico familiar benigno) es una dermatosis ampollosa, de evolución crónica, recidivante, autosómica dominante, de penetrancia y expresividad variables, localizada predominantemente en los pliegues. Presentamos el caso de una mujer de 58 años de edad que presentaba una erupción cutánea pruriginosa, eccematosa, localizada en las axilas e ingles, en forma de brotes recurrentes de 36 años de evolución. La biopsia cutánea reveló una intensa acantólisis que daba lugar a una ampolla intraepidérmica suprabasal. Se instauró tratamiento con antibióticos orales y corticoides y antibióticos tópicos, con desaparición de las lesiones pocos días después. Queremos destacar la buena respuesta de nuestra paciente al tratamiento instaurado. Hailey-Hailey disease (familial benign chronic) is an autosomal dominant hereditary bullous disorder characterized by recurrent lesions predominating in folds with variable penetrance and expressisivity (AU)

Penfigoide ampolloso producido por captopril / Bullous pemphigoid associated with captopril

Presentamos el caso de un varón de 82 años que, tras iniciar un tratamiento con captopril, desarrolló una erupción cutánea ampollosa cuyos estudio histopatológico e inmunofluorescencia fueron compatibles con penfigoide ampolloso. Tras suspender el tratamiento con captopril e instaurar un tratamiento con corticoides, la afección desapareció (AU)

Las manifestaciones cutáneas asociadas a hemorragia gastrointestinal

La piel y el tracto gastrointestinal son dos aparatos en estrecha relación. Existen numerosas enfermedades que afectan primariamente al tracto gastrointestinal con manifestaciones cutáneas que, en muchos casos, pueden ser la clave diagnóstica del proceso digestivo subyacente. La hemorragia digestiva es un problema cuya incidencia en nuestro medio supera los 150 casos por 100.000 habitantes y cuya mortalidad estimada es del 10 por ciento de los casos. En el presente artículo revisaremos las enfermedades vasculares del tracto gastrointestinal y otros procesos digestivos que cursan con hemorragia, que presentan manifestaciones cutáneas características, destacando su descripción e importancia clínicas y su tratamiento. (AU)