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1.
Artigo em Inglês | MEDLINE | ID: mdl-36141846

RESUMO

Among university students there has been evidence that the COVID-19 pandemic increased their psychological distress, exacerbated by social restrictions. The main objective of this study was to explore the impact of the COVID-19 pandemic on the prevalence and patterns of cannabis use among university students, in contrast to previous trends since 2012. Data from 10,522 first-year university students (73.3% female, Mage 19 (SD = 1.6)) from eleven Spanish universities collected between 2012 and May 2022 was analysed. Prevalences of cannabis use and their differences by sex were studied, as well as changes in patterns of use and its use for coping during the pandemic. It was found that during lockdown, all prevalence rates of cannabis use decreased in both sexes, showing no statistically significant differences and increasing again in the new normal period in both. Among regular cannabis users, 79.7% reported maintaining or increasing their cannabis use during the pandemic, and of these, half reported using cannabis to cope. Moreover, cannabis use in the usual household increased during the lockdown. These results show that although the overall prevalence of cannabis use was reduced during the lockdown, regular users tended to maintain or increase cannabis use. This could imply two different patterns of use among students, one social and occasional versus the other regular, providing new lines of research for prevention and the implementation of social policies.


Assuntos
COVID-19 , Cannabis , Adulto , COVID-19/epidemiologia , Controle de Doenças Transmissíveis , Feminino , Humanos , Masculino , Pandemias , Prevalência , Espanha/epidemiologia , Estudantes/psicologia , Universidades , Adulto Jovem
2.
Eur J Intern Med ; 102: 80-87, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35570127

RESUMO

AIMS: To develop a simple multivariate predictor model of incident type 2 diabetes in general population. METHODS: Participants were recruited from the Spanish Di@bet.es cohort study with 2570 subjects meeting all criteria to be included in the at-risk sample studied here. Information was collected using an interviewer-administered structured questionnaire, followed by physical and clinical examination. CHAID algorithm, which collects the information of individuals with and without type 2 diabetes, was used to develop a decision tree based type 2 diabetes prediction model. RESULTS: 156 individuals were identified as having developed type 2 diabetes (6.5% incidence). Fasting plasma glucose (FPG) at the beginning of the study was the main predictive variable for incident type 2 diabetes: FPG ≤ 92 mg/dL (ref.), 92-106 mg/dL (OR = 3.76, 95%CI = 2.36-6.00), > 106 mg/dL (OR = 13.21; 8.26-21.12). More than 25% of subjects starting follow-up with FPG levels > 106 mg/dL developed type 2 diabetes. When FPG <106 mg/dL, other variables (fasting triglycerides (FTGs), BMI or age) were needed. For levels ≤ 92 mg/dL, higher FTGs levels increased risk of incident type 2 diabetes (FTGs > 180 mg/dL, OR = 14.57; 4.89-43.40) compared with the group of FTGs ≤ 97 mg/dL (FTGs  = 97-180 mg/dL, OR = 3.12; 1.05-9.24). This model correctly classified 93.5% of individuals. CONCLUSIONS: The type 2 diabetes prediction model is based on FTGs, FPG, age, gender, and BMI values. Utilizing commonly available clinical data and a simple blood test, a simple tree diagram helps identify subjects at risk of developing type 2 diabetes, even in apparently low risk subjects with normal FPG.


Assuntos
Diabetes Mellitus Tipo 2 , Glicemia , Estudos de Coortes , Diabetes Mellitus Tipo 2/epidemiologia , Jejum , Humanos , Incidência , Fatores de Risco
3.
J Environ Manage ; 308: 114587, 2022 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-35121452

RESUMO

The profiling of emerging organic pollutants present in sludge and generated during wastewater treatment is much more limited than in water. This is mainly due to the difficulty of sludge analysis because of its high content of organic matter and interfering compounds. In this study, a generic extraction method using a mixture of buffered water (pH 4.1) and solid phase extraction (SPE) clean-up was applied to samples of sludge obtained in different treatment plants. This extraction was followed by determination of the contaminants by ultra-high performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC-HRMS), using suspected screening to detect the most relevant organic compounds that access the environment through sludge application. This screening (including >3000 substances, such as, pharmaceuticals, pesticides, metabolites and industrial chemicals) tentatively identified 122 compound and assigned most probable structure to 39. The set of compounds assigned to a probable structure was increased in 14 compounds by searching in a free database of metabolites. Fifteen compounds were unequivocally confirmed against the analytical standard. Pharmaceuticals and personal care products (PPCPs), with 31 substances identified and 8 confirmed were the main group of compounds. Compounds frequently detected in all sludge samples include nucleotides such as adenosine triphosphate, amino acids such as phenylalanine, or peptides such as leu-phe. Altogether, the results of this work highlight the interest of HRMS to draw the profile of organic compounds in complex matrices.


Assuntos
Poluentes Químicos da Água , Purificação da Água , Compostos Orgânicos , Esgotos/química , Extração em Fase Sólida/métodos , Poluentes Químicos da Água/análise
4.
Hacia promoc. salud ; 25(1): 90-108, 20200000. tab
Artigo em Inglês, Espanhol, Português | LILACS | ID: biblio-1051175

RESUMO

Objective: identify constraints of patients with acute febrile syndrome to institutional care services access, emphasizing the identification of communication barriers. Method: this is a descriptive study that involves qualitative research techniques including malaria care service patients as well as assistance and administrative personnel of El Bagre town in Antioquia, Colombia in 2016. Semi-structured individual surveys, interviews and focus groups were used. Results: users listed difficulties including transportation, insufficient number of appointments and absence of personnel to access healthcare. Communication difficulties were related to the information provided in the paperwork and documents filled out to attend healthcare facilities, scarce information about diagnostic, control, and adherence to antimalarial treatment; additionally some patients did not use Spanish to communicate in oral or write form. Conclusion: the creation of health models based on structural transformations that encompass the needs of Healthcare System actors and communities is a must, which allows the establishment of foundations for a multicultural society project


Objetivo: Identificar limitaciones de los pacientes con síndrome febril agudo para acceder a los servicios de atención institucional, con énfasis en la identificación de barreras de comunicación.Método: Estudio descriptivo que involucra técnicas de investigación cualitativa con pacientes de los servicios de atención de la malaria y con personal asistencial y administrativo del municipio de El Bagre Antioquia, Colombia en el 2016. Se aplicaron encuestas semiestructuradas individuales, entrevistas y grupos focales. Los usuarios señalaron dificultades con el transporte, insuficiente número de citas y falta de personal para acceder a la atención. Resultados: Las dificultades de comunicación se relacionaron con la información suministrada sobre trámites y documentación para asistir a los puestos de salud, poca información sobre el diagnóstico, control y adherencia al tratamiento antimalárico y el no uso de algunos pacientes del español para comunicarse en forma verbal o escrita. Conclusiones: Esto exige crear modelos de salud basados en transformaciones estructurales que abarquen las necesidades de los actores del sistema de salud y las comunidades, permitiendo establecer las bases para un proyecto multicultural de sociedad.


Objetivo: Identificar limitações dos pacientes com síndrome febril agudo para aceder aos serviços de atenção institucional, com ênfase na identificação de barreiras de comunicação. Método: Estudo descritivo que involucra técnicas de pesquisa qualitativa com pacientes dos serviços de atenção da malária e com equipe assistencial e administrativo do município do Bagre Antioquia, Colômbia no 2016. Fizeram-se enquetes semiestruturadas individuais, entrevistas e grupos focais. Os usuários sinalaram dificuldades com o transporte, insuficiente número de horas marcadas e falta de pessoal para aceder à atenção. Resultados: As dificuldades de comunicação se relacionaram com a informação subministrada sobre trâmites e documentação para chegar aos SUS (Sistema Único de Saúde), pouca informação sobre o diagnóstico, controle e aderência ao tratamento antimalárico e o não uso de alguns pacientes do espanhol para comunicar-se em forma verbal ou escrita. Conclusões: Isto exige criar modelos de saúde baseados em transformações estruturais que abarquem as necessidades dos atores do sistema de saúde e as comunidades, permitindo estabelecer as bases para um projeto multicultural de sociedade.


Assuntos
Humanos , Acessibilidade aos Serviços de Saúde , Barreiras de Comunicação , Malária , Mineração
6.
Acta otorrinolaringol. esp ; 69(4): 219-225, jul.-ago. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-180487

RESUMO

INTRODUCCIÓN Y OBJETIVOS: Los síntomas de vértigo y mareo son frecuentes en la población, se presentan como manifestación de un amplio abanico de enfermedades y habitualmente es difícil realizar un diagnóstico de certeza. El objetivo general de este estudio es obtener la información para evaluar estos síntomas en el entorno hospitalario. Los objetivos específicos son: estimar el peso global que representan estos síntomas en las derivaciones al hospital; conocer las características de los pacientes derivados y detallar el flujo de las consultas. MÉTODOS: Estudio descriptivo observacional. Se buscaron las propuestas de consulta realizadas en 2011 y 2012 al hospital por el síntoma de vértigo. Se analizaron características demográficas y clínicas de los pacientes, y administrativas de las derivaciones. RESULTADOS: Se analizaron un total de 558 propuestas correspondientes a 494 pacientes. El vértigo supuso el 0,5% del total de las derivaciones realizadas desde Atención Primaria al hospital. El 63% de la muestra han sido mujeres, con una edad media de 58 años. El 88% de los pacientes fue valorado por Otorrinolaringología y el 24% por Neurología. Un 30,8% consultó en 3 o más ocasiones por el síntoma. El 16% fue valorado por enfermedad psiquiátrica en el hospital. CONCLUSIONES: El vértigo como síntoma supone una carga significativa en el ámbito hospitalario. Los pacientes que lo presentan consultan en múltiples ocasiones y son valorados en distintas especialidades. En ciertos casos, el flujo de pacientes puede resultar excesivamente dinámico e ineficaz. En nuestro entorno, Otorrinolaringología es el principal receptor de pacientes con síntomas de vértigo y mareo


INTRODUCTION AND OBJECTIVES: Vertigo and dizziness as symptoms are frequent in the population. They are present in a wide range of pathologies and it is usually difficult to make an accurate diagnosis. The general objective of this study is to obtain the information to evaluate vertigo and dizziness in the hospital setting. The specific objectives are: to estimate the burden of these symptoms at the hospital; to study patients' conditions and to detail the flow of these patients inside the hospital. METHODS: Observational descriptive study. We made a search of the referral proposals made in 2011 and 2012 to the hospital because of vertigo symptoms. The patients' demographic and clinical characteristics, and the administrative details of the referrals were analysed. RESULTS: A total of 558 proposals were analysed corresponding to 494 patients. Vertigo accounted for 0.5% of all referrals made from Primary Care to the hospital. Sixty-three percent of the sample were women; the average age was 58 years. Eighty-eight percent of the patients were evaluated by Otorhinolaryngology, 24% by Neurology. Thirty point eight percent consulted on 3 or more occasions for the symptom. Sixteen percent were assessed for psychiatric conditions in the hospital. CONCLUSIONS: Vertigo as a symptom is a significant burden in the hospital setting. The patients who suffer it consult on several occasions and are assessed by different specialties. This implies in some cases an excessive and ineffective flow of patients. In our setting, otorhinolaryngology is the main department to treat vertigo and dizziness patients


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Vertigem/diagnóstico , Vertigem/epidemiologia , Vertigem/terapia , Tontura/diagnóstico , Tontura/epidemiologia , Tontura/terapia , Estudo Observacional , Estudos Transversais , Encaminhamento e Consulta/estatística & dados numéricos , Estudos Retrospectivos
7.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29033126

RESUMO

INTRODUCTION AND OBJECTIVES: Vertigo and dizziness as symptoms are frequent in the population. They are present in a wide range of pathologies and it is usually difficult to make an accurate diagnosis. The general objective of this study is to obtain the information to evaluate vertigo and dizziness in the hospital setting. The specific objectives are: to estimate the burden of these symptoms at the hospital; to study patients' conditions and to detail the flow of these patients inside the hospital. METHODS: Observational descriptive study. We made a search of the referral proposals made in 2011 and 2012 to the hospital because of vertigo symptoms. The patients' demographic and clinical characteristics, and the administrative details of the referrals were analysed. RESULTS: A total of 558 proposals were analysed corresponding to 494 patients. Vertigo accounted for 0.5% of all referrals made from Primary Care to the hospital. Sixty-three percent of the sample were women; the average age was 58 years. Eighty-eight percent of the patients were evaluated by Otorhinolaryngology, 24% by Neurology. Thirty point eight percent consulted on 3 or more occasions for the symptom. Sixteen percent were assessed for psychiatric conditions in the hospital. CONCLUSIONS: Vertigo as a symptom is a significant burden in the hospital setting. The patients who suffer it consult on several occasions and are assessed by different specialties. This implies in some cases an excessive and ineffective flow of patients. In our setting, otorhinolaryngology is the main department to treat vertigo and dizziness patients.


Assuntos
Tontura , Vertigem , Adolescente , Adulto , Idoso , Estudos Transversais , Tontura/diagnóstico , Tontura/epidemiologia , Tontura/terapia , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Encaminhamento e Consulta/estatística & dados numéricos , Estudos Retrospectivos , Vertigem/diagnóstico , Vertigem/epidemiologia , Vertigem/terapia , Adulto Jovem
8.
Ars pharm ; 55(2): 1-10[2], abr.-jun. 2014. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-125915

RESUMO

Objetivo: Analizar la actividad científica y la producción de información de la revista Ars Pharmaceutica como publicación científica española de referencia en el área de la farmacia. Material y Método: Estudio descriptivo transversal de los resultados obtenidos del análisis bibliométrico de los artículos publicados en la revista, obteniéndose los datos de la consulta directa y acceso, vía Internet, a la literatura científica recogida en la versión electrónica de la revista en el periodo 2001 a 2013. Resultados: Durante el periodo estudiado se publicaron 623 artículos. El número de originales fue de 387 (62,12%), siendo el índice de productividad de 2,59. Se identificaron 173 instituciones con trabajos publicados. El idioma predominante fue el español con 396 (63,56%) artículos. Se contabilizaron 1925 palabras clave, de las cuales 441 (22,91%) se correspondían con Descriptores de Ciencias de la Salud (DeCS). La obsolescencia de las referencias citadas, medida por la mediana fue 7 y el Índice de Price fue del 34,37%. El porcentaje de autocitas fue del 1,80%. Los datos de impacto presentaron un moderado crecimiento. Conclusiones: Se comprobó una apropiada proporción de artículos originales y adecuado porcentaje de artículos citables adecuados. Es reseñable el bajo porcentaje de Palabras Clave que coinciden con los DeCS. Las referencias bibliográficas recogidas en sus artículos proceden mayoritariamente del ámbito anglófono y de revistas indizadas en la Journal Citation Report. El análisis de la obsolescencia de estas referencias dio resultados adecuados


Aim: To analyze the scientific activity and the production of information of the Ars Pharmaceutica journal as the Spanish scientific publication of reference in the pharmaceutical area. Materials and Methods: Transversal descriptive study of the results obtained from the bibliometric analysis of the articles published in the journal. Data was obtained from direct queries and Internet access to the scientific literature contained in the electronic version of the journal during the 2001-2013 period. Results: During the period studied 623 articles were published. The number of original articles was 387 (62.12%) with a productivity index of 2.59. The number of institutions identified with published articles was 173. The predominant language was Spanish with 396 (63.56%) articles. We counted 1925 keywords, of which 441 (22.91%) coincided with Medical Subject Headings (MeSH). The median calculation of the obsolescence of quoted references was 7, and the Price Index was 34.37%. The percentage of self-citations was 1.80%. Impact data showed a moderate increase. Conclusions: An appropriate proportion of original articles were found and an adequate percentage of satisfactory citable articles. The low percentage of keywords that coincide with Medical Subject Headings is noteworthy. The bibliographical references found in the articles come mainly from the English-speaking area and from journals indexed in the Journal Citation Report. The obsolescence analysis of these references produced suitable


Assuntos
Bibliometria , Publicações/estatística & dados numéricos , Acesso à Informação , Farmácia/tendências , 50088 , Publicações Periódicas como Assunto/estatística & dados numéricos , Publicação Periódica , Fator de Impacto de Revistas , Medical Subject Headings
11.
Arch Argent Pediatr ; 111(5): 398-404, 2013 10.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-24092027

RESUMO

INTRODUCTION: A sedentary lifestyle is not only a major cardiovascular risk factor from an early age, it also contributes to the development of other cardiovascular risk factors. The objective of this study was to determine the level of physical activity and relate it to cardiovascular risk markers in Valencian adolescents according to their anthropometric characteristics and gender. POPULATION AND METHODS: The following variables were assessed in a randomized sample of 583 Valencian adolescents (Spain) aged 12-18 years: level of physical activity, using a validated questionnaire; weight, height and waist circumference; aerobic capacity, using the multi-stage ftness test (Course-Navette test); and muscle strength, using a manual dynamometry. RESULTS: In total, 57.60% of male adolescents and 14% of female adolescents complied with the recommendations for physical activity. The prevalence of excessive weight, waist circumference with risk, and aerobic capacity with risk was 24.90%, 29.30% and 20.60%, respectively among boys, and 15.10%, 23.20% and 24.70% among girls (p <0.005). CONCLUSIONS: A higher level of physical activity in adolescents is related to a lower body mass index, a smaller waist circumference and less excessive weight in male adolescents, and to a higher aerobic capacity and a lower cardiovascular risk in both male and female adolescents. Aerobic capacity and waist circumference with risk are signifcantly higher among subjects with excessive weight.


Assuntos
Doenças Cardiovasculares , Atividade Motora , Adolescente , Pesos e Medidas Corporais , Doenças Cardiovasculares/epidemiologia , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Fatores de Risco , Espanha
12.
Arch. argent. pediatr ; 111(5): 398-404, Oct. 2013. ilus, tab
Artigo em Inglês | BINACIS | ID: bin-130903

RESUMO

Introduction. A sedentary lifestyle is not only a major cardiovascular risk factor from an early age, it also contributes to the development of other cardiovascular risk factors. The objective of this study was to determine the level of physical activity and relate it to cardiovascular risk markers in Valencian adolescents according to their anthropometric characteristics and gender. Population and Methods. The following variables were assessed in a randomized sample of 583 Valencian adolescents (Spain) aged 12-18 years: level of physical activity, using a validated questionnaire; weight, height and waist circumference; aerobic capacity, using the multi-stage ftness test (Course-Navette test); and muscle strength, using a manual dynamometry. Results. In total, 57.60% of male adolescents and 14% of female adolescents complied with the recommendations for physical activity. The prevalence of excessive weight, waist circumference with risk, and aerobic capacity with risk was 24.90%, 29.30% and 20.60%, respectively among boys, and 15.10%, 23.20% and 24.70% among girls (p <0.005). Conclusions. A higher level of physical activity in adolescents is related to a lower body mass index, a smaller waist circumference and less excessive weight in male adolescents, and to a higher aerobic capacity and a lower cardiovascular risk in both male and female adolescents. Aerobic capacity and waist circumference with risk are signifcantly higher among subjects with excessive weight.(AU)


Introducción. El sedentarismo no solo es un factor de riesgo cardiovascular importante desde edades tempranas, sino que además contribuye al desarrollo de otros factores de riesgo cardiovascular. El objetivo de este trabajo fue determinar el nivel de práctica de actividad física y relacionarlo con marcadores de riesgo cardiovascular en adolescentes valencianos, según las características antropométricas y el género. Población y métodos. En una muestra aleatoria de 583 adolescentes valencianos (España), de 12 a 18 años, se evaluó el nivel de práctica de actividad física mediante un cuestionario validado; el peso, la talla y la circunferencia abdominal; la capacidad aeróbica mediante la prueba de Course-Navette y la fuerza muscular mediante la dinamometría manual. Resultados. Cumplían las recomendaciones de práctica de actividad física el 57,60% de los varones y el 14% de las mujeres. La prevalencia de exceso de peso, circunferencia abdominal con riesgo y capacidad aeróbica con riesgo fue de 24,90%, 29,30% y 20,60%, respectivamente en los varones y de 15,10%, 23,20% y 24,70% en las mujeres (p < 0,005). Conclusiones. Un mayor nivel de práctica de actividad física en los adolescentes se relaciona con menor índice de masa corporal, menor circunferencia abdominal y menor exceso de peso en los varones, y con mayor capacidad aeróbica y menor riesgo cardiovascular en ambos sexos. La capacidad aeróbica con riesgo y la circunferencia abdominal con riesgo son signifcativamente mayores en los sujetos con exceso de peso.(AU)


Assuntos
Adolescente , Criança , Feminino , Humanos , Masculino , Doenças Cardiovasculares , Atividade Motora , Pesos e Medidas Corporais , Doenças Cardiovasculares/epidemiologia , Estudos Transversais , Fatores de Risco , Espanha
13.
Arch. argent. pediatr ; 111(5): 398-404, Oct. 2013. ilus, tab
Artigo em Inglês | LILACS | ID: lil-694668

RESUMO

Introduction. A sedentary lifestyle is not only a major cardiovascular risk factor from an early age, it also contributes to the development of other cardiovascular risk factors. The objective of this study was to determine the level of physical activity and relate it to cardiovascular risk markers in Valencian adolescents according to their anthropometric characteristics and gender. Population and Methods. The following variables were assessed in a randomized sample of 583 Valencian adolescents (Spain) aged 12-18 years: level of physical activity, using a validated questionnaire; weight, height and waist circumference; aerobic capacity, using the multi-stage ftness test (Course-Navette test); and muscle strength, using a manual dynamometry. Results. In total, 57.60% of male adolescents and 14% of female adolescents complied with the recommendations for physical activity. The prevalence of excessive weight, waist circumference with risk, and aerobic capacity with risk was 24.90%, 29.30% and 20.60%, respectively among boys, and 15.10%, 23.20% and 24.70% among girls (p <0.005). Conclusions. A higher level of physical activity in adolescents is related to a lower body mass index, a smaller waist circumference and less excessive weight in male adolescents, and to a higher aerobic capacity and a lower cardiovascular risk in both male and female adolescents. Aerobic capacity and waist circumference with risk are signifcantly higher among subjects with excessive weight.


Introducción. El sedentarismo no solo es un factor de riesgo cardiovascular importante desde edades tempranas, sino que además contribuye al desarrollo de otros factores de riesgo cardiovascular. El objetivo de este trabajo fue determinar el nivel de práctica de actividad física y relacionarlo con marcadores de riesgo cardiovascular en adolescentes valencianos, según las características antropométricas y el género. Población y métodos. En una muestra aleatoria de 583 adolescentes valencianos (España), de 12 a 18 años, se evaluó el nivel de práctica de actividad física mediante un cuestionario validado; el peso, la talla y la circunferencia abdominal; la capacidad aeróbica mediante la prueba de Course-Navette y la fuerza muscular mediante la dinamometría manual. Resultados. Cumplían las recomendaciones de práctica de actividad física el 57,60% de los varones y el 14% de las mujeres. La prevalencia de exceso de peso, circunferencia abdominal con riesgo y capacidad aeróbica con riesgo fue de 24,90%, 29,30% y 20,60%, respectivamente en los varones y de 15,10%, 23,20% y 24,70% en las mujeres (p < 0,005). Conclusiones. Un mayor nivel de práctica de actividad física en los adolescentes se relaciona con menor índice de masa corporal, menor circunferencia abdominal y menor exceso de peso en los varones, y con mayor capacidad aeróbica y menor riesgo cardiovascular en ambos sexos. La capacidad aeróbica con riesgo y la circunferencia abdominal con riesgo son signifcativamente mayores en los sujetos con exceso de peso.


Assuntos
Adolescente , Criança , Feminino , Humanos , Masculino , Doenças Cardiovasculares , Atividade Motora , Pesos e Medidas Corporais , Estudos Transversais , Doenças Cardiovasculares/epidemiologia , Fatores de Risco , Espanha
14.
J Occup Environ Med ; 55(8): 924-31, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23887697

RESUMO

OBJECTIVE: To evaluate the potential association between occupational exposure to chlorinated and petroleum solvents and mycosis fungoides (MF). METHODS: A questionnaire on lifetime job history was administered to 100 patients diagnosed with MF and 2846 controls. Odds ratios (ORs) were calculated as the measure of the association between exposure to each specific solvent and MF. RESULTS: In the total sample and in men, cases and controls did not differ in relation to exposure to any of the solvents studied. In women, an association with MF was seen for the highest level of estimated exposure to perchloroethylene (OR = 11.38; 95% confidence interval: 1.04 to 124.85) and for exposure less than the median to kerosene/fuel/gasoil (OR = 8.53; 95% confidence interval: 1.11 to 65.62). CONCLUSIONS: These results do not provide conclusive evidence that exposure to solvents may increase risk of MF because they were not found in men.


Assuntos
Hidrocarbonetos Clorados/efeitos adversos , Micose Fungoide/induzido quimicamente , Exposição Ocupacional/efeitos adversos , Petróleo/efeitos adversos , Neoplasias Cutâneas/induzido quimicamente , Adulto , Idoso , Estudos de Casos e Controles , Feminino , Óleos Combustíveis/efeitos adversos , Humanos , Querosene/efeitos adversos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Fatores Sexuais , Solventes/efeitos adversos , Inquéritos e Questionários , Tetracloroetileno/efeitos adversos
15.
Dermatoendocrinol ; 5(3): 358-62, 2013 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-24516690

RESUMO

Low serum 25-hydroxyvitamin D [25(OH)D] levels have been associated with increased prevalence of cardiovascular diseases. A possible relation between lipids and 25(OH)D might explain this association. This investigation aimed to determine the association between vitamin D and cholesterol, as well as the influence of statins on this association. This was a cross-sectional population-based study with 177 subjects aged 18-84 years. We collected demographics and data on sun exposure, sun protection habits, current medication including lipid-lowering drugs, and estimated vitamin D intake. Serum measurements included levels of 25(OH)D, parathyroid hormone (PTH), calcium, phosphorus, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and fasting glucose. The mean 25(OH)D level was 24 ± 9 ng/ml. Young age (P = 0.04) and spending more than 1 h outdoors (P = 0.04) were independently associated with higher 25(OH)D levels. The 25(OH)D concentrations correlated negatively with total cholesterol (P = 0.01) and LDL cholesterol (P = 0.04) levels. The adjusted OR for total cholesterol > 200 mg/ml was 2.8 (range, 1.1-7.5). Receiving statins was associated with higher 25(OH)D levels (P = 0.04). In conclusion, this study supports an association between 25(OH)D levels and cholesterol. Further studies are required to explain this association.

16.
Arch Argent Pediatr ; 111(5): 398-404, 2013 Oct.
Artigo em Espanhol | BINACIS | ID: bin-132940

RESUMO

INTRODUCTION: A sedentary lifestyle is not only a major cardiovascular risk factor from an early age, it also contributes to the development of other cardiovascular risk factors. The objective of this study was to determine the level of physical activity and relate it to cardiovascular risk markers in Valencian adolescents according to their anthropometric characteristics and gender. POPULATION AND METHODS: The following variables were assessed in a randomized sample of 583 Valencian adolescents (Spain) aged 12-18 years: level of physical activity, using a validated questionnaire; weight, height and waist circumference; aerobic capacity, using the multi-stage ftness test (Course-Navette test); and muscle strength, using a manual dynamometry. RESULTS: In total, 57.60


of male adolescents and 14


of female adolescents complied with the recommendations for physical activity. The prevalence of excessive weight, waist circumference with risk, and aerobic capacity with risk was 24.90


, 29.30


and 20.60


, respectively among boys, and 15.10


, 23.20


and 24.70


among girls (p <0.005). CONCLUSIONS: A higher level of physical activity in adolescents is related to a lower body mass index, a smaller waist circumference and less excessive weight in male adolescents, and to a higher aerobic capacity and a lower cardiovascular risk in both male and female adolescents. Aerobic capacity and waist circumference with risk are signifcantly higher among subjects with excessive weight.


Assuntos
Doenças Cardiovasculares , Atividade Motora , Adolescente , Pesos e Medidas Corporais , Doenças Cardiovasculares/epidemiologia , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Fatores de Risco , Espanha
18.
Acta otorrinolaringol. esp ; 63(5): 332-338, sept.-oct. 2012. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-102715

RESUMO

Introducción y objetivos: La posturografía permite evaluar el control postural de un sujeto. En este estudio se presentan aquellos parámetros biomecánicos del sistema de posturografía empleado, que han resultado útiles para valorar funcionalmente los pacientes vestibulares de nuestra muestra. Material y métodos: De un total de 89 participantes, 59 eran sujetos sanos y 30 presentaban un trastorno vestibular periférico. Todos ellos realizaron un estudio posturográfico mediante el sistema NedSVE/IBV que combina pruebas estáticas (Romberg) y dinámicas (límites de estabilidad y control rítmico-direccional). Posteriormente se compararon las medidas halladas en uno y otro grupo. Resultados: Los sujetos normales presentaron menores oscilaciones que los enfermos en los distintos parámetros posturográficos estudiados (excepto en el ángulo de desplazamiento)de forma estadísticamente significativa. En la prueba de los límites de estabilidad, aunque los sujetos normales lograron desplazamientos máximos mayores que los enfermos, las diferencias halladas no fueron significativas. En la prueba de control rítmico y direccional, los sujetos normales presentaron resultados más favorables que los patológicos y las diferencias fueron significativas en 3 de los 4 parámetros estudiados: 1) habilidad anteroposterior, 2) habilidad mediolateral, y 3) control y eficacia anteroposterior. Conclusión: Los parámetros del sistema de posturografía estática empleado y la prueba de control rítmico y direccional resultaron de utilidad para discriminar entre los sujetos normales y patológicos de nuestra muestra (AU)


Introduction and objective: Posturography allows evaluating postural control. This study showed the posturographic parameters that were useful for assessing the functional ability to maintain balance in our sample of vestibular patients. Material and methods: Of a total of 89 patients, 59 were healthy subjects and 30 had a peripheral vestibular disorder. The subjects were studied using the posturographic NedSVE/IBV system, combining static (Romberg) and dynamic (stability limits and rhythmic weight shifts) tests. We then compared the measurements found in the groups. Results: Normal subjects showed significantly lower oscillations than our patients in all of the posturographic parameters studied (except the displacement angle). In testing the limits of stability, although normal subjects achieved maximum displacements greater than the subjects with the disorder, the differences found were not significant. In rhythmic weight shift tests, normal subjects showed more favourable results than did the vestibular patients, with significant differences in 3 of the 4 parameters studied: 1) anteroposterior ability, 2) mediolateral ability, and 3) anteroposterior control and efficiency. Conclusion: Rhythmic weight shift tests and the static posturography test parameters used were useful in discriminating among the normal and pathological subjects in this study (AU)


Assuntos
Humanos , Postura/fisiologia , Transtornos de Sensação/diagnóstico , Doenças Vestibulares/diagnóstico , Vertigem/diagnóstico , Posicionamento do Paciente/métodos , Doença de Meniere/diagnóstico , Neuronite Vestibular/diagnóstico
19.
Arch Med Sci ; 8(2): 236-43, 2012 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-22661995

RESUMO

INTRODUCTION: To assess the possible role and the interaction of cerebrovascular disease and vascular stenosis on the necessity of shunt insertion during carotid endarterectomy (CEA). MATERIAL AND METHODS: Eighty consecutive patients undergoing CEA under regional anaesthesia were prospectively enrolled. Patients were divided into two groups depending on whether they were shunted or not. The measured end-points were co-morbidities degree of contralateral and carotid stenosis and other intra- and postoperative outstanding parameters. ANOVA, Student's t and χ(2) tests were used (p<0.05). Variables differing significantly between groups and potential confounders were used in backward stepwise logistic regression to estimate the relative risk (RR, 95% CI) of shunt. In addition Wald's test (p<0.05) with and without adjustments for potential confounders was used with various different multivariate analysis models. RESULTS: Contralateral stenosis and cerebral vascular accidents (CVA) were more frequently observed in shunted patients. The RR for patients with contralateral stenosis ≥ 50% was 1.3 (95% CI 1.0-1.5) and for patients with previous CVA was 1.2 (95% CI 1.0-1.4). For contralateral stenosis and CVA together the RR increased to 7.7 (95% CI 1.0-14.4). A model based on contralateral stenosis and CVA was found to be statistically significant (p=0.003) for shunt (RR=1.1, 95% CI 1.0-2.1). Relative excess risk due to interaction of both factors was 6.2. CONCLUSIONS: The findings suggest that patients with contralateral stenosis ≥ 50% and previous CVA have a higher risk of requiring shunt use during CEA than patients with these risk factors separately.

20.
Acta Otorrinolaringol Esp ; 63(5): 332-8, 2012.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-22633316

RESUMO

INTRODUCTION AND OBJECTIVE: Posturography allows evaluating postural control. This study showed the posturographic parameters that were useful for assessing the functional ability to maintain balance in our sample of vestibular patients. MATERIAL AND METHODS: Of a total of 89 patients, 59 were healthy subjects and 30 had a peripheral vestibular disorder. The subjects were studied using the posturographic NedSVE/IBV system, combining static (Romberg) and dynamic (stability limits and rhythmic weight shifts) tests. We then compared the measurements found in the groups. RESULTS: Normal subjects showed significantly lower oscillations than our patients in all of the posturographic parameters studied (except the displacement angle). In testing the limits of stability, although normal subjects achieved maximum displacements greater than the subjects with the disorder, the differences found were not significant. In rhythmic weight shift tests, normal subjects showed more favourable results than did the vestibular patients, with significant differences in 3 of the 4 parameters studied: 1) anteroposterior ability, 2) mediolateral ability, and 3) anteroposterior control and efficiency. CONCLUSION: Rhythmic weight shift tests and the static posturography test parameters used were useful in discriminating among the normal and pathological subjects in this study.


Assuntos
Equilíbrio Postural/fisiologia , Testes de Função Vestibular/métodos , Adulto , Idoso , Audiometria de Tons Puros , Fenômenos Biomecânicos , Testes Calóricos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nistagmo Fisiológico , Doenças Vestibulares , Testes de Função Vestibular/instrumentação
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