Young Children of Mothers with a History of Depression Show Attention Bias to Sad Faces: An Eye-tracking Study.

Maternal depression is a predictor of the emergence of depression in the offspring. Attention bias (AB) to negative emotional stimuli in children may serve as a risk factor for children of depressed parents. The present study aimed to examine the effect of maternal major depressive disorder (MDD) history on AB to emotional faces in children at age four, before the age of onset for full-blown psychiatric symptoms. The study also compared AB patterns between mothers and their offspring. Fifty-eight mothers and their four-year-old children participated in this study, of which 27 high-risk (HR) children had mothers with MDD during their children's lifetime. Attention to emotional faces was measured in both children and their mothers using an eye-tracking visual search task. HR children exhibited faster detection and longer dwell time toward the sad than happy target faces. The low-risk (LR) children also displayed a sad bias but to a lesser degree. Children across both groups showed AB towards angry target faces, likely reflecting a normative AB pattern. Our findings indicate that AB to sad faces may serve as an early marker of depression risk. However, we provided limited support for the mother-child association of AB. Future research is needed to examine the longitudinal intergenerational transmission of AB related to depression and possible mechanisms underlying the emergence of AB in offspring of depressed parents.

Neural activation to peer acceptance and rejection in relation to concurrent and prospective depression risk in adolescent and pre-adolescent girls.

Neurobiological sensitivity to peer interactions is a proposed marker of risk for adolescent depression. We investigated neural response to peer rejection and acceptance in relation to concurrent and prospective depression risk in adolescent and pre-adolescent girls. Participants were 76 girls (Mage=13, 45% racial/ethnic minorities) varying in depression risk: 22 with current major depressive disorder (MDD), 30 at High Risk for MDD based on parental history, and 24 at Low Risk with no psychiatric history. Girls participated in the Chatroom-Interact task-involving rejection and acceptance feedback from fictitious peers-while undergoing functional magnetic resonance neuroimaging. Activation in response to peer rejection and acceptance was extracted from regions of interest. Depressive symptoms were assessed at 6- and 12-month follow-up. Girls with MDD showed blunted left subgenual anterior cingulate response to acceptance versus girls in High and Low Risk groups. Girls in the High Risk group showed greater right temporo-parietal junction (rTPJ) and right anterior insula (AI) activation to both acceptance and rejection versus girls in the MDD (rTPJ) and Low Risk (rTPJ, AI) groups. Greater rTPJ response to rejection was associated with fewer depressive symptoms at 12-months and mediated the association between High Risk group status and 12-month depressive symptoms; greater rTPJ response to acceptance mediated the association between High Risk and increased 12-month depressive symptoms. Our finding of associations between altered neural response to peer interactions and concurrent and prospective depression risk/resilience highlights the importance of neural underpinnings of social cognition as risk and compensatory adaptations along the pathway to depression.

Exogenous testosterone administration is associated with differential neural response to unfamiliar peer's and own caregiver's voice in transgender adolescents.

Changes in gonadal hormones during puberty are thought to potentiate adolescents' social re-orientation away from caregivers and towards peers. This study investigated the effect of testosterone on neural processing of emotional (vocal) stimuli by unfamiliar peers vs. parents, in transgender boys receiving exogenous testosterone as a gender-affirming hormone (GAH+) or not (GAH-). During fMRI, youth heard angry and happy vocal expressions spoken by their caregiver and an unfamiliar teenager. Youth also self-reported on closeness with friends and parents. Whole-brain analyses (controlling for age) revealed that GAH+ youth showed blunted neural response to caregivers' angry voices-and heightened response to unfamiliar teenage angry voices-in the anterior cingulate cortex. This pattern was reversed in GAH- youth, who also showed greater response to happy unfamiliar teenager vs. happy caregiver voices in this region. Blunted ACC response to angry caregiver voices-a pattern characteristic of GAH+ youth-was associated with greater relative closeness with friends over parents, which could index more "advanced" social re-orientation. Consistent with models of adolescent neurodevelopment, increases in testosterone during adolescence may shift the valuation of caregiver vs. peer emotional cues in a brain region associated with processing affective information.

Adolescents and young adults differ in their neural response to and recognition of adolescent and adult emotional faces.

Peer relationships become increasingly important during adolescence. The success of these relationships may rely on the ability to attend to and decode subtle or ambiguous emotional expressions that are common in social interactions. However, most studies examining youths' processing and labeling of facial emotion have employed adult faces and faces that depict emotional extremes as stimuli. In this study, 40 adolescents and 40 young adults viewed blends of angry-neutral, fearful-neutral, and happy-neutral faces (e.g., 100% angry, 66% angry, 33% angry, neutral) portrayed by adolescent and adult actors as electroencephalogram (EEG) was recorded. Participants also labeled these faces according to the emotion expressed (i.e., angry, fearful, happy, or neutral). The Late Positive Potential (LPP), an event-related potential (ERP) component that reflects sustained attention to motivationally salient information, was scored from the EEG following face presentation. Among adolescents, as peer-age faces moved from ambiguous (33%) to unambiguous (100%) emotional expression, the LPP similarly increased. These effects were not found when adolescents viewed emotional face blends portrayed by adult actors. Additionally, while both adolescents and young adults showed greater emotion labeling accuracy as faces increased in emotional intensity from ambiguous to unambiguous emotional expression, adolescent participants did not show greater accuracy when labeling peer-compared to adult-age faces. Together, these data suggest that adolescents attend more to subtle differences in peer-age emotional faces, but they do not label these emotional expressions more accurately than adults.

Longitudinal change in neural response to vocal emotion in adolescence.

Adolescence is associated with maturation of function within neural networks supporting the processing of social information. Previous longitudinal studies have established developmental influences on youth's neural response to facial displays of emotion. Given the increasing recognition of the importance of non-facial cues to social communication, we build on existing work by examining longitudinal change in neural response to vocal expressions of emotion in 8- to 19-year-old youth. Participants completed a vocal emotion recognition task at two timepoints (1 year apart) while undergoing functional magnetic resonance imaging. The right inferior frontal gyrus, right dorsal striatum and right precentral gyrus showed decreases in activation to emotional voices across timepoints, which may reflect focalization of response in these areas. Activation in the dorsomedial prefrontal cortex was positively associated with age but was stable across timepoints. In addition, the slope of change across visits varied as a function of participants' age in the right temporo-parietal junction (TPJ): this pattern of activation across timepoints and age may reflect ongoing specialization of function across childhood and adolescence. Decreased activation in the striatum and TPJ across timepoints was associated with better emotion recognition accuracy. Findings suggest that specialization of function in social cognitive networks may support the growth of vocal emotion recognition skills across adolescence.

Recognition of vocal socioemotional expressions at varying levels of emotional intensity.

Nonverbal expressions of emotion can vary in intensity, from ambiguous to prototypical exemplars: for instance, facial displays of happiness may range from a faint smile to a full-blown grin. Previous work suggests that the accuracy with which facial expressions are recognized as the intended emotion increases with emotional intensity, although this pattern depends on the displayed emotion. Less is known about the association between emotional intensity and the recognition of vocal emotional expressions (affective prosody), which also convey information about others' socioemotional intent but are perceived and interpreted differently than facial expressions. The current study examined listeners' ability to recognize emotional intent in morphed vocal prosody recordings that varied in emotional intensity from neutral to prototypical exemplars of basic emotions (anger, disgust, fear, happiness, sadness) and social expressions (friendliness, meanness). Results suggest that listeners' accuracy in identifying the intended emotional intent in each recording increased nonlinearly with emotional intensity. This pattern varied by emotion type: for instance, accuracy for anger rose steeply with increasing emotional intensity before plateauing, whereas accuracy for happiness remained unchanged across low-intensity exemplars but increased thereafter. These findings highlight emotion-specific ways in which dynamic changes in emotional intensity inform perceptions of socioemotional intent in emotional prosody. Moreover, these results also point to potential challenges in emotional communication in social interactions that rely primarily on the voice, with many low-intensity expressions having a higher probability of being misinterpreted. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Testosterone treatment, internalizing symptoms, and body image dissatisfaction in transgender boys.

OBJECTIVE: Many transgender adolescents experience clinically elevated anxiety and depression. Testosterone (T), used as a gender affirming treatment, may reduce symptoms of anxiety and depression. We assessed the effect of gender affirming T treatment on internalizing symptoms, body image dissatisfaction, and activation patterns within the amygdala-prefrontal cortex circuit in transgender adolescent boys. METHOD: Symptoms of generalized anxiety, social anxiety, depression, suicidality and body image dissatisfaction were measured by self-report and brain activation was measured during a face processing task with functional MRI in a group of 19 adolescent transgender boys receiving T treatment and 23 not receiving gonadal hormone treatment (UT). RESULTS: Severity of anxiety and depression was significantly lower in the T treated group relative to the UT group, along with a trend of lower suicidality. The T group also reported less distress with body features and exhibited stronger connectivity within the amygdala-prefrontal cortex circuit compared to the UT group. Finally, group differences on depression and suicidality were directly associated with body image dissatisfaction, and anxiety symptoms were moderated by amygdala-prefrontal cortex connectivity differences between groups. CONCLUSION: T treatment is associated with lower levels of internalizing symptoms among transgender adolescent boys. T is also associated with greater body satisfaction and greater connectivity in a neural circuit associated with anxiety and depression. Satisfaction with body image was found to overlap with the association between T and both depression and suicidality, and amygdala-prefrontal co-activation moderated the role of T on anxiety.

Atypical age-related changes in the structure of the mentalizing network in children with refractory focal epilepsy.

Refractory focal epilepsy (rFE) is commonly comorbid with impaired social functioning, which significantly reduces quality of life. Previous research has identified a mentalizing network in the brain-composed of the anterior temporal cortex, medial prefrontal cortex (mPFC), posterior temporal sulcus (pSTS), and temporoparietal junction-that is thought to play a critical role in social cognition. In typically-developing (TD) youth, this network undergoes a protracted developmental process with cortical thinning and white matter expansion occurring across adolescence. Because epilepsy is associated with both social dysfunction and irregular neural development, we investigated whether gray and white matter in the mentalizing network differed between youth with rFE (n = 22) and TD youth (n = 41) aged 8-21 years. Older age was associated with reduced cortical thickness in the bilateral mPFC in TD youth, but not in rFE youth. Compared to TD youth, rFE youth had greater white matter density in the right pSTS. Our findings suggest that rFE youth show atypical patterns of cortical thickness and white matter density in regions of the brain that are typically associated with social information processing, potentially as a result of ongoing seizures, comorbid conditions, or other illness-related factors. These results encourage future research to examine whether such variations in neural structure are predictive of specific social deficits in rFE youth.

Categorization of Vocal Emotion Cues Depends on Distributions of Input.

Learners use the distributional properties of stimuli to identify environmentally relevant categories in a range of perceptual domains, including words, shapes, faces, and colors. We examined whether similar processes may also operate on affective information conveyed through the voice. In Experiment 1, we tested how adults (18-22-year-olds) and children (8-10-year-olds) categorized affective states communicated by vocalizations varying continuously from "calm" to "upset." We found that the threshold for categorizing both verbal (i.e., spoken word) and nonverbal (i.e., a yell) vocalizations as "upset" depended on the statistical distribution of the stimuli participants encountered. In Experiment 2, we replicated and extended these findings in adults using vocalizations that conveyed multiple negative affect states. These results suggest perceivers' flexibly and rapidly update their interpretation of affective vocal cues based upon context. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s42761-021-00038-w.

Blunted neural response to emotional faces in the fusiform and superior temporal gyrus may be marker of emotion recognition deficits in pediatric epilepsy.

Individuals with epilepsy are at risk for social cognition deficits, including impairments in the ability to recognize nonverbal cues of emotion (i.e., emotion recognition [ER] skills). Such deficits are particularly pronounced in adult patients with childhood-onset seizures and are already evident in children and adolescents with epilepsy. Though these impairments have been linked to blunted neural response to emotional information in faces in adult patients, little is known about the neural correlates of ER deficits in youth with epilepsy. The current study compared ER accuracy and neural response to emotional faces during functional magnetic resonance imaging (fMRI) in youth with intractable focal epilepsy and typically developing youth. Relative to typically developing participants, individuals with epilepsy showed a) reduced accuracy in the ER task and b) blunted response to emotional faces (vs. neutral faces) in the bilateral fusiform gyri and right superior temporal gyrus (STG). Activation in these regions was correlated with performance, suggesting that aberrant response within these face-responsive regions may play a functional role in ER impairments. Reduced engagement of neural circuits relevant to processing socioemotional cues may be markers of risk for social cognitive deficits in youth with focal epilepsy.

Loneliness and the recognition of vocal socioemotional expressions in adolescence.

Lonely individuals show increased social monitoring and heightened recognition of negative facial expressions. The current study investigated whether this pattern extends to other nonverbal modalities by examining associations between loneliness and the recognition of vocal emotional expressions. Youth, ages 11-18 years (n = 122), were asked to identify the intended emotion in auditory portrayals of basic emotions (anger, disgust, fear, happiness, sadness) and social expressions (friendliness, meanness). Controlling for social anxiety, age, and gender, links between loneliness and recognition accuracy were emotion-specific: loneliness was associated with poorer recognition of fear, but better recognition of friendliness. Lonely individuals' motivation to avoid threat may interfere with the recognition of fear, but their attunement to affiliative cues may promote the identification of friendliness in affective prosody. Monitoring for social affiliation cues in others' voices might represent an adaptive function of the reconnection system in lonely youth, and be a worthy target for intervention.

Internalizing symptoms in intractable pediatric epilepsy: Structural and functional brain correlates.

Internalizing disorders (i.e., depression and anxiety) are common comorbidities in people with epilepsy. In adults with epilepsy, comorbid depression or anxiety is associated with worse seizure control and reduced quality of life, and may be linked to specific neural biomarkers. Less is known about brain correlates of internalizing symptoms in pediatric populations. In the current study, we performed a retrospective analysis of 45 youth between the ages of 6 and 18 years old with intractable epilepsy. Individuals were evaluated for internalizing symptoms on the Child Behavior Checklist (CBCL) and underwent magnetic resonance (MR) and fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging as part of the clinical evaluation for surgical treatment of epilepsy. Forty-two percent of patients experienced clinically significant internalizing symptoms based on parent report. Compared with individuals who scored in the normal range, youth with clinical levels of internalizing problems showed overall reductions in cortex volume, as well as widespread reductions in cortical thickness and functional activation in the bilateral occipital/parietal lobe, left temporal regions, and left inferior frontal cortex on MR and PET scans. There were no group differences in amygdala or hippocampus volumes, nor other patient- or illness-related variables such as age, sex, or the type, lateralization, or duration of epilepsy. Results suggest that high rates of internalizing disorders are present in youth with refractory epilepsy. Multifocal reductions in cortical thickness and function may be nonspecific risk factors for clinically meaningful internalizing symptoms in youth with chronic epilepsy. As such, the presence of broad cortical thinning and reduced glucose uptake upon radiological examination may warrant more focused clinical evaluation of psychological symptoms.

Age-related differences in neural activation and functional connectivity during the processing of vocal prosody in adolescence.

The ability to recognize others' emotions based on vocal emotional prosody follows a protracted developmental trajectory during adolescence. However, little is known about the neural mechanisms supporting this maturation. The current study investigated age-related differences in neural activation during a vocal emotion recognition (ER) task. Listeners aged 8 to 19 years old completed the vocal ER task while undergoing functional magnetic resonance imaging. The task of categorizing vocal emotional prosody elicited activation primarily in temporal and frontal areas. Age was associated with a) greater activation in regions in the superior, middle, and inferior frontal gyri, b) greater functional connectivity between the left precentral and inferior frontal gyri and regions in the bilateral insula and temporo-parietal junction, and c) greater fractional anisotropy in the superior longitudinal fasciculus, which connects frontal areas to posterior temporo-parietal regions. Many of these age-related differences in brain activation and connectivity were associated with better performance on the ER task. Increased activation in, and connectivity between, areas typically involved in language processing and social cognition may facilitate the development of vocal ER skills in adolescence.

Associations Between Adolescents' Social Re-orientation Toward Peers Over Caregivers and Neural Response to Teenage Faces.

Adolescence is a period of intensive development in body, brain, and behavior. Potentiated by changes in hormones and neural response to social stimuli, teenagers undergo a process of social re-orientation away from their caregivers and toward expanding peer networks. The current study examines how relative relational closeness to peers (compared to parents) during adolescence is linked to neural response to the facial emotional expressions of other teenagers. Self-reported closeness with friends (same- and opposite-sex) and parents (mother and father), and neural response to facial stimuli during fMRI, were assessed in 8- to 19-year-old typically developing youth (n = 40, mean age = 13.90 years old, SD = 3.36; 25 female). Youth who reported greater relative closeness with peers than with parents showed decreased activation in the dorsolateral prefrontal cortex (dlPFC) during stimulus presentation, which may reflect lessened inhibitory control or regulatory response to peer-aged faces. Functional connectivity between the dlPFC and dorsal striatum was greatest in older youth who were closer to peers; in contrast, negative coupling between these regions was noted for both younger participants who were closer to peers and older participants who were closer to their parents. In addition, the association between relative closeness to peers and neural activation in regions of the social brain varied by emotion type and age. Results suggest that the re-orientation toward peers that occurs during adolescence is accompanied by changes in neural response to peer-aged social signals in social cognitive, prefrontal, and subcortical networks.

Associations Between Anxious and Depressive Symptoms and the Recognition of Vocal Socioemotional Expressions in Youth.

The current study examined the associations between internalizing symptoms and adolescents' recognition of vocal socioemotional expressions produced by youth. Fifty-seven youth (8-17 years old, M = 12.62, SD = 2.66; 29 anxious, 28 nonanxious; 32 female, 25 male) were asked to identify the intended expression in auditory recordings of youth's portrayals of basic emotions and social attitudes. Recognition accuracy increased with age, suggesting that the ability to recognize vocal affect continues to develop into adolescence. Anxiety symptoms were not associated with recognition ability, but youth's depressive symptoms were related to poorer identification of anger and happiness. Youth experiencing symptoms of depression may be likely to misinterpret vocal expressions of happiness and anger.

Changes in parental prosody mediate effect of parent-training intervention on infant language production.

OBJECTIVE: Parent-training interventions to reduce behavior problems in young children typically coach parents on the content of their speech, but rarely assess parents' prosody during parent-child interactions. Infant-directed speech helps shape the parent-infant relationship and promote language development, which predicts adaptive behavioral outcomes in children. The current study examined (a) the effect of a parent-training intervention on parents' vocal cues in interactions with their infant and (b) whether parental prosody mediated the impact of the intervention on infant language production. METHOD: Sixty families with 12- to 15-month-old infants (47% female; 95% of Hispanic/Latino ethnicity) participated in the Infant Behavior Program (IBP), a brief home-based adaptation of Parent-Child Interaction Therapy, or received standard pediatric care. Speech analysis was performed on mothers' (n = 40) utterances during infant-led play pre- and postintervention. Infants' number of utterances spoken during play was assessed at pre- and postintervention, and at 3- and 6-month follow-ups. RESULTS: Mothers who received the IBP spoke with greater pitch range and slower tempo postintervention, when controlling for baseline prosody. Change in these vocal cues, which are typical of infant-directed speech, mediated the effect of the intervention on infants' word production after 6 months. CONCLUSIONS: Interventions targeting the content of parents' speech during parent-infant interactions may lead to changes in parental prosody, which may be beneficial for infants' language development. Impaired linguistic abilities in infancy are strongly associated with behavior problems in later childhood; thus, these findings highlight a potential mechanism for intervention efficacy in promoting positive socioemotional and behavioral outcomes. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Differences in adult and adolescent listeners' ratings of valence and arousal in emotional prosody.

Judgments of emotional stimuli's valence and arousal can differ based on the perceiver's age. With most of the existing literature on age-related changes in such ratings based on perceptions of visually-presented pictures or words, less is known about how youth and adults perceive and rate the affective information contained in auditory emotional stimuli. The current study examined age-related differences in adolescent (n = 31; 45% female; aged 12-17, M = 14.35, SD = 1.68) and adult listeners' (n = 30; 53% female; aged 21-30, M = 26.20 years, SD = 2.98) ratings of the valence and arousal of spoken words conveying happiness, anger, and a neutral expression. We also fitted closed curves to the average ratings for each emotional expression to determine their relative position on the valence-arousal plane of an affective circumplex. Compared to adults, adolescents' ratings of emotional prosody were generally higher in valence, but more constricted in range for both valence and arousal. This pattern of ratings is suggestive of lesser differentiation amongst emotional categories' holistic properties, which may have implications for the successful recognition and appropriate response to vocal emotional cues in adolescents' social environments.

Maturation of vocal emotion recognition: Insights from the developmental and neuroimaging literature.

Emotions are implicitly expressed in both facial expressions and prosodic components of vocal communication. The ability to recognize nonverbal cues of emotion is an important feature of social competence that matures gradually across childhood and adolescence. Compared to the extensive knowledge about the development of emotion recognition (ER) from facial displays of emotion, relatively little is known about the maturation of this ability in the auditory domain. The current review provides an overview of knowledge about the development of vocal emotion recognition from behavioural studies, and neural mechanisms that might contribute to this maturational process. Youth are thought to reach adult-like vocal ER ability in early or late adolescence. At a neural level, several structural and functional changes occur in the adolescent brain that may impact the representation of emotional information. However, there is a paucity of developmental neuroimaging work directly examining neural prosody processing in youth. We speculate that brain areas relevant to vocal perception in adults may undergo age-related changes that map onto increased vocal ER capacity.

Listeners feel the beat: entrainment to English and French speech rhythms.

Can listeners entrain to speech rhythms? Monolingual speakers of English and French and balanced English-French bilinguals tapped along with the beat they perceived in sentences spoken in a stress-timed language, English, and a syllable-timed language, French. All groups of participants tapped more regularly to English than to French utterances. Tapping performance was also influenced by the participants' native language: English-speaking participants and bilinguals tapped more regularly and at higher metrical levels than did French-speaking participants, suggesting that long-term linguistic experience with a stress-timed language can differentiate speakers' entrainment to speech rhythm.