RESUMO
OBJECTIVE: To identify risk factors for developing a first febrile status epilepticus (FSE) among children with a first febrile seizure (FS). STUDY DESIGN: Cases were children with a first FS that was FSE drawn from the Consequences of Prolonged Febrile Seizures in Childhood and Columbia cohorts. Controls were children with a first simple FS and separately, children with a first complex FS that was not FSE. Identical questionnaires were administered to family members of the 3 cohorts. Magnetic resonance imaging protocol and readings were consistent across cohorts, and seizure phenomenology was assessed by the same physicians. Risk factors were analyzed using logistic regression. RESULTS: Compared with children with simple FS, FSE was associated with younger age, lower temperature, longer duration (1-24 hours) of recognized temperature before FS, female sex, structural temporal lobe abnormalities, and first-degree family history of FS. Compared with children with other complex FS, FSE was associated with low temperature and longer duration (1-24 hours) of temperature recognition before FS. Risk factors for complex FS that was not FSE were similar in magnitude to those for FSE but only younger age was significant. CONCLUSIONS: Among children with a first FS, FSE appears to be due to a combination of lower seizure threshold (younger age and lower temperatures) and impaired regulation of seizure duration. Clinicians evaluating FS should be aware of these factors as many episodes of FSE go unnoticed. Further work is needed to develop strategies to prevent FSE.
Assuntos
Convulsões Febris/complicações , Estado Epiléptico/etiologia , Estudos de Casos e Controles , Pré-Escolar , Estudos de Coortes , Saúde da Família , Feminino , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Razão de Chances , Análise de Regressão , Fatores de Risco , Convulsões Febris/patologia , Estado Epiléptico/patologia , Inquéritos e Questionários , Fatores de TempoRESUMO
This prospective multicenter study of 200 patients with fever-associated status epilepticus (FSE), of whom 136 underwent a nontraumatic lumbar puncture, confirms that FSE rarely causes cerebrospinal fluid (CSF) pleocytosis. CSF glucose and protein levels were unremarkable. Temperature, age, seizure focality, and seizure duration did not affect results. CSF pleocytosis should not be attributed to FSE.
Assuntos
Convulsões Febris/líquido cefalorraquidiano , Estado Epiléptico/líquido cefalorraquidiano , Biomarcadores/líquido cefalorraquidiano , Proteínas do Líquido Cefalorraquidiano/metabolismo , Criança , Glucose/líquido cefalorraquidiano , Humanos , Leucócitos/metabolismo , Leucocitose/líquido cefalorraquidiano , Leucocitose/etiologia , Estudos Prospectivos , Convulsões Febris/fisiopatologia , Punção Espinal , Estado Epiléptico/etiologiaRESUMO
Existe uma crescente controvérsia quanto ao fato das crises convulsivas no período neonatal produzirem ou näo esclerose hipocampal que levaria ao desenvolvimento de uma epilepsia de difícil controle mais tarde na infância ou idade adulta. Nesta revisäo, fazemos um resumo de dados novos baseados em modelos de desenvolvimento da epilepsia. Essas descobertas sugerem que em animais normais, o hipocampo imaturo resiste ao desenvolvimento da esclerose. Esses resultados devem ser considerados quando forem tratados aspectos da intervençäo precoce incluindo cirurgia e tratamento medicamentoso agressivo