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1.
Radiobiologiia ; 29(1): 89-93, 1989.
Artigo em Russo | MEDLINE | ID: mdl-2928492

RESUMO

In experiments with rats a study was made of the influence of pregnancy and lactation as well as of trivalent and bivalent iron on the resorption of 7BeCl2 from the digestive tract and distribution thereof among organs and tissues.


Assuntos
Berílio/farmacocinética , Absorção Intestinal , Radioisótopos/farmacocinética , Animais , Feminino , Absorção Intestinal/efeitos dos fármacos , Ferro/farmacologia , Lactação , Gravidez , Ratos
2.
Radiobiologiia ; 28(4): 542-4, 1988.
Artigo em Russo | MEDLINE | ID: mdl-3420229

RESUMO

Evidence was obtained that beta-carotene injected to rats subcutaneously or per os two times, 4 h and 19 h, before irradiation reduced their death rate from acute affection. The effect was almost invariable with the drug administered either before or after irradiation. The radioprotective efficacy of beta-carotene was attributed to its ability to scavenge active oxygen forms.


Assuntos
Carotenoides/uso terapêutico , Protetores contra Radiação/uso terapêutico , Doença Aguda , Animais , Células Sanguíneas/efeitos dos fármacos , Células Sanguíneas/efeitos da radiação , Avaliação Pré-Clínica de Medicamentos , Feminino , Raios gama , Masculino , Lesões Experimentais por Radiação/tratamento farmacológico , Lesões Experimentais por Radiação/mortalidade , Ratos , Ratos Endogâmicos , Fatores de Tempo , beta Caroteno
13.
Radiobiologiia ; 24(1): 122-5, 1984.
Artigo em Russo | MEDLINE | ID: mdl-6709834

RESUMO

A study was made of the kinetics of metabolism and distribution of 249Bk within the albino rat body. After the intraperitoneal administration of 249Bk nitrate, the radionuclide circulated with blood for a long time and was deposited mainly in the skeleton (up to 39.8% of the quantity administered) and liver (18.4%). The radionuclide concentrations in the adrenal glands, liver, spleen, kidneys and osseous tissue were 7.3, 3.2, 1.3, 1.1, and 1.2%, respectively, of the quantity administered per 1 g of fresh tissue. 249Bk was mainly excreted in urea. During 30 days of observation 18.2% and 10.4%, of the quantity administered, were excreted in urea and feces, respectively.


Assuntos
Berkélio/metabolismo , Animais , Fezes/análise , Feminino , Cinética , Ratos , Fatores de Tempo , Distribuição Tecidual
14.
Radiobiologiia ; 24(1): 99-100, 1984.
Artigo em Russo | MEDLINE | ID: mdl-6709854

RESUMO

A study was made of the kinetics of 241Am metabolism in a rat body during long-term parenteral administration thereof. It was shown that americium 241 was deposited mainly in the skeleton and liver (47% and 51%, respectively, of the total amount accumulated in the organism) and excreted in feces.


Assuntos
Amerício/metabolismo , Animais , Fezes/análise , Cinética , Ratos , Fatores de Tempo , Distribuição Tecidual
15.
Eksp Onkol ; 6(3): 36-8, 1984.
Artigo em Russo | MEDLINE | ID: mdl-6499740

RESUMO

It is shown that 249Bk nitrate injected intraperitoneally in a wide range of doses to albino mongrel female rats is preferentially accumulated in the bony tissue (39.8%) and liver (18.4%). Incorporation of 249Bk to rats results in development of osteosarcomas, neoplasms of hemopoietic and lymphoid tissues, mammary tumours, thyroid and pituitary glands.


Assuntos
Berkélio , Neoplasias Induzidas por Radiação/etiologia , Animais , Carga Corporal (Radioterapia) , Relação Dose-Resposta à Radiação , Feminino , Neoplasias Mamárias Experimentais/etiologia , Ratos
16.
Radiobiologiia ; 23(6): 823-4, 1983.
Artigo em Russo | MEDLINE | ID: mdl-6657949

RESUMO

In experiments on 600 mice, relative biological effectiveness of tritium oxide was compared to that of gamma-radiation (137Cs) with respect to the response of CFUc. It was shown that RBE of tritium oxide was 1 within the dose range from 0.8 to 0.4 Gy.


Assuntos
Ensaio de Unidades Formadoras de Colônias , Células-Tronco Hematopoéticas/efeitos da radiação , Trítio , Água , Animais , Relação Dose-Resposta à Radiação , Feminino , Raios gama , Camundongos , Eficiência Biológica Relativa
17.
Radiobiologiia ; 23(6): 844-7, 1983.
Artigo em Russo | MEDLINE | ID: mdl-6657956

RESUMO

In this report, L.A. Iléen, Academician of the USSR Academy of Medical Sciences amd Chairman of the National Commission of Radiation Protection (NCRP) of the USSR Ministry of Health, Professor L.A. ++Buldakov, Professor Yu. I. Moskalev and Director G.M. Avetisov, Scientific Secretary of the NCRP, advanced the radiobiological aspects of the work of the Commission in the period of 1982 - 1986 which were approved at the Meeting of the Commission on April 23, 1982.


Assuntos
Proteção Radiológica , Radiobiologia , Academias e Institutos , Órgãos Governamentais , Humanos , U.R.S.S. , Nações Unidas
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