1.
Bioorg Med Chem Lett
; 23(5): 1375-8, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23337600
RESUMO
(Me)FGC(Bz)DEVD was radiolabeled with technetium-99m in high yield. This tracer was preferentially accumulated in apoptotic cells in the in vitro studies. Tumor uptake occurred in vivo after cisplatin injection due to the apoptosis induction, which not observed in the untreated tumors. Therefore, (99m)Tc-(Me)FGCDEVD is a potential tracer for apoptosis detection.