Current trends of balloon laryngoplasty in Thailand.

OBJECTIVE: To describe the current trend in balloon laryngoplasty usage and experience by practicing otolaryngologists in Thailand. STUDY DESIGN: Anonymous 11 question online and paper survey of otolaryngologists on their current balloon laryngoplasty practices. SUBJECTS AND METHODS: Current practices and experience in balloon laryngoplasty were queried with multiple choice and open-ended questions. RESULTS: Laser use is the most commonly utilized instrument to treat airway stenosis in Thailand. 86% of respondents do not have experience with balloon dilatation; yet, almost half (47.6%) report they perform a minimum of five airway surgeries per year. Most respondents had been in practice for less than 6 years (41%) and reported that they did not have exposure to balloon use during residency training. The largest barrier reported for the use of balloon instrumentation in the airway is inexperience (44.4%) followed by cost (38.3%), yet most feel that treatment in airway stenosis could benefit by usage of balloons (95.5%). CONCLUSIONS: Most otolaryngologists in Thailand do not have experience with the use of balloon dilatation and lack of exposure remains the largest barrier to its use. Otolaryngologists in Thailand feel that increased usage of balloons in the airway could improve airway stenosis treatment in the country.

A Surveillance Bacteriological Study of Acute Bacterial Rhinosinusitis in Thailand and the Clinical Responses to the Culture-directed Antibiotics.

OBJECTIVE: To examine: 1) types of bacteria and antimicrobial sensitivity of commonly used antibiotics for acute bacterial rhinosinusitis (ABRS) in Thailand, 2) the effectiveness of using antibiotics according to antimicrobial sensitivity, and 3) the effectiveness of using antibiotics according to the Thai clinical practice guidelines (CPG) of ABRS. MATERIAL AND METHOD: Descriptive & experimental studies were conducted in seven tertiary hospitals in Thailand. The specimens from maxillary sinuses were taken for bacterial cultures either by maxillary sinus tap or endoscopically directed middle meatus swabs in patients with clinically diagnosed ABRS. Antimicrobial sensitivity was performed and antibiotics were prescribed according to the results of antimicrobial sensitivity or the Thai CPG of ABRS. RESULTS: A total of 113 patients were enrolled between August 2006 and April 2007, 104 cases of which were performed for bacteriological study. The incidence of bacterial growth was 60.6% (95% CI 51.0-69.4%). The most common bacteria was H. influenzae (25.0%, 95% CI 16.9-35.3%), followed by S. pneumoniae (14.3%, 95% CI 8.2-23.5%) and S. aureus (9.5%, 95% CI 4.7-17.9%), respectively, whilst M. catarrhalis was found only in 2.4% (95% CI 0.5-7.3%). Eight in 12 S. pneumoniae isolates were tested for the minimal inhibitory concentration of penicillin and found to be penicillin resistant strain in five specimens. Beta-lactamase producing H. influenzae was found in eight out of 20 isolates. H. influenzae had a tendency to be sensitive to amoxicillin/clavulanate, cefuroxime, cefpodoxime, azithromycin, clarithromycin, ofloxacin, levofloxacin and gatifloxacin, whilst S. pneumoniae had a tendency to be sensitive to amoxicillin/clavulanate, cefaclor ampicillin/sulbactam, cefuroxime, ofloxacin, levofloxacin, gatifloxacin, cefpodoxime, cefixime and cefdinir. The effectiveness of antibiotics prescription according to the Thai CPG of ABRS and antimicrobial sensitivity were comparable, 88.5% (95% CI 69.8-97.6%) and 82.2% (95% CI 67.9-92%), respectively. CONCLUSION: H. influenzae is found to be the most common bacteria in Thai ABRS, followed by S. pneumoniae and S. aureus. There is a high incidence of beta-lactamase producing H. influenzae and penicillin non-susceptible S. pneumoniae.

Haemophilus influenzae type b as an important cause of culture-positive acute otitis media in young children in Thailand: a tympanocentesis-based, multi-center, cross-sectional study.

BACKGROUND: Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae (H. influenzae) are considered major causes of bacterial acute otitis media (AOM) worldwide, but data from Asia on primary causes of AOM are limited. This tympanocentesis-based, multi-center, cross-sectional study assessed bacterial etiology and antimicrobial susceptibility of AOM in Thailand. METHODS: Children 3 to 59 months presenting with AOM (< 72 hours of onset) who had not received prescribed antibiotics, or subjects who received prescribed antibiotics but remained symptomatic after 48-72 hours (treatment failures), were eligible. Study visits were conducted from April 2008 to August 2009. Bacteria were identified from middle ear fluid collected by tympanocentesis or spontaneous otorrhea swab sampling (< 20% of cases). S. pneumoniae and H. influenzae serotypes were determined and antimicrobial resistance was also assessed. RESULTS: Of the 123 enrolled children, 112 were included in analysis and 48% of the 118 samples were positive for S. pneumoniae (23% (27/118)), H. influenzae (18% (21/118)), Moraxella catarrhalis (6% (7/118)) or Streptococcus pyogenes (3% (4/118)). The most common pneumococcal serotypes were 19F (26%) and 14 (22%). The majority of H. influenzae isolates were encapsulated (18/21), with 13 type b (Hib) representing 62% of all H. influenzae isolate or 11% of all samples (13/118), and there were only 3 non-typeable isolates. Despite high antibiotic resistance, amoxicillin/clavulanate susceptibility was high. No pneumococcal vaccine use was reported. CONCLUSIONS: S. pneumoniae and H. influenzae, both frequently antibiotic resistant, were leading causes of bacterial AOM and there was an unexpectedly high burden of Hib in this population unvaccinated by any Hib conjugate vaccine. Conjugate vaccines effective against pneumococcus and H. influenzae could potentially reduce the burden of AOM in this population.

Efficacy of the Precise Climate Controller on the reduction of indoor microorganisms.

BACKGROUND: Nowadays, there are many methods to reduce microorganisms in the air, such as dehumidifier, air purifier or humidity and temperature controller. The Precise Climate Controller is an instrument for controlling humidity and temperature, a concept that is demonstrated. OBJECTIVE: To determine the efficacy of this device, in order to reduce the quantity of the fungi and bacteria in the closed system. METHODS: This study is a perspective experimental study and is conducted as follows - the air sample in the closed system, a 42-cubic-meter room, is collected before the installation of the Precise Climate Controller. Next, the room is fumed with Aspergillus flavus and closed for 2 days. Then the instrument is in use in order to keep the relative humidity (RH) and the temperature constant at 55% RH and 25 degrees Celsius (℃). The air samples are collected every 3 days for 5 times during the period of 15 days to identify the type and calculate the quantity of the microorganisms. RESULTS: Before the Precise Climate Controller has been installed. Three species of bacteria are found in the air samples, but none of the fungus exists in the testing room. Once the room has been fumed with a large amount of A. flavus and the instrument is in use for 3 days, nine colonies of A. flavus are identified, but later on when the instrument is in use for 6, 9, 12, and 15 days, the air samples contain neither fungus nor bacteria. CONCLUSION: After keeping the RH and temperature of the closed system constant at 55% RH and 25℃ by using the Precise Climate Controller, it is found that the efficaciousness in controlling the quantity and species of fungi and bacteria is clinically significant.

Otologic manifestations from blast injuries among military personnel in Thailand.

BACKGROUND: From November 2008 to October 2010, 565 military personnel sustained blast injury in Southernmost Thailand and 99 personnel, affected by multiple injuries, were transferred to Phramongkutklao Hospital. No data on the effect of blast injury to the ears among Thai military personnel have been reported. This study aims 1) to determine the prevalence of Sensorineural Hearing Loss (SNHL) and otologic manifestations from primary blast injury among military personnel, in Pattani, Yala and Narathiwat Provinces, and 2) to evaluate the impact of explosive devices and distance from explosion on SNHL under various conditions. MATERIALS AND METHODS: A cross-sectional study was conducted among 76 military personnel injured from blast injury in Southernmost Thailand. They were divided into three groups representing the bomb blast settings; open-space referred to an area without barrier, semi-open space referred to a room open on at least one side and closed space referred to a room enclosed with four walls and ceiling. RESULTS: The otologic manifestations from 76 patients were tinnitus, tympanic membrane perforation, bleeding and open wound. The prevalence of SNHL among patients in the open-, semi-open and closed space groups was 62.77%, 67.86% and 73.33%, respectively. The most common type of explosive was Improvised Explosive Devices (IEDs) 72 (94.74%). The average IED weighed 11.42kg and mean distance from explosion was 5.66m. CONCLUSION: Correlation among all three incident areas and two factors: impact of explosive devices and distance from explosion are risk factors of SNHL without significance.

Prevalence of tonsillectomy and adenoidectomy complication at Phramongkutklao Hospital.

UNLABELLED: Tonsillectomy and adenoidectomy, one of the major procedures among otolaryngologist, may have risk in post operative complications which can be either non severe complications (dysphagia, wound pain, dehydration) or serious complications (Bleeding, partial airway obstruction). Meticulous attention to surgical techniques and technical advance in anesthesiology have significantly reduced the number of complications. In Thailand, there are few reports about the adenotonsillectomy complications so the objectives of the present study were to determine the prevalence and related risk factors in patients visiting the department of Otolaryngology, Phramongkutklao Hospital. OBJECTIVE: To determine the prevalence ofcomplications and related risk factors in patients who underwent adenotonsillectomy in Phramongkutklao Hospital. MATERIAL AND METHOD: The patients who had undergone adenotonsillectomy from January 2003 to December 2006 in the department of Otolaryngology, Phramongkutklao Hospital was retrospectively and prospectively reviewed. Information extracted included age, tonsillar size, indication for surgery, the post operative complications (anesthetic complication, primary bleeding, secondary bleeding, airway obstruction, dysphagia, wound pain, dehydration, length of stay in hospital and re-admission. RESULTS: Four hundred and eighty-one patients were enrolled, of which 36.8% were younger than 12 years-old and 63.2% were over 12 years-old; 39.3% male and 60.7% female. Indication for surgery provided by chronic hypertrophic tonsillitis 73%, obstructive sleep apnea 23.5%, peritonsillar abscess and others 3.5%. The prevalence of complications was anesthetic complication 1.6%, primary bleeding 4.1%, secondary bleeding 3.9%, dysphagia 29.0%, dehydration 4.6%, wound pain 48.1%. The average length of hospital stay was 3.6 days and re-admission 3.7%. CONCLUSION: The prevalence of post operative complication after tonsillectomy and adenoidectomy was low but higher than other previous studies included the primary bleeding and secondary bleeding.

Prevalence of allergic rhinitis and types of sensitized allergen in adult at Wat Intaram community, Hua Raeu, Phra Nakhon Si Ayutthaya District, Phra Nakhon Si Ayutthaya Province, Thailand.

UNLABELLED: Allergic rhinitis is a common problem in many countries. The incidence of Allergic rhinitis is about 10-25% of the population and increasing worldwide especially in large cities where air pollution is the main problem causing respiratory illness. In Thailand, the surveys of allergic rhinitis on children were found about 13-44% while the prevalence of allergic rhinitis in Thai adults was as high as 20%. The information of the prevalence of allergic rhinitis in the suburban area has not been continuously done especially in the adult population. OBJECTIVE: To present study the prevalence of allergic rhinitis and other atopic diseases and to determine the aeroallergen sensitivity of allergic patients in suburban area. MATERIAL AND METHOD: Observational descriptive cross-sectional study as one-stage cluster sampling, Using ISAAC questionnaires interviewed adults at War Intaram community, Hua Raeu, Phra Nakhon Si Ayutthaya District, Phra Nakhon Si Ayutthaya Province, Thailand during September-October 2008. Participants who had allergic rhinitis symptoms described in the questionnaires were enrolled to perform the skin prick test voluntary to determine the aeroallergen sensitivity. RESULTS: There were 324 subjects, female 64.8% and male 35.2%. Age ranges between 20-66 years old (mean 42.2). The prevalence of allergic rhinitis, asthma and chronic pruritic rash were 37.7%, 16%, 21.3% and history of allergic rhinitis, asthma and chronic pruritic rash within 12 months were 32.1%, 10.5%, 17.3%. The sensitized allergen was mixed mite (62.2%), mixed cockroach (61.1%), house dust (48.9%), cat (37.8%), Johnson glass (30.0%), dog (20.0%), careless weed (20.0%), mixed mold (12.2%), cotton (7.8%) and feather (6.7%). CONCLUSION: The present study revealed that the prevalence of allergic rhinitis and atopic diseases has been increasing in number when compared with previous reports. The most common sensitized allergen was Mite mix, similar to other studies, but mixed cockroach was found significantly higher.

Prevalence of etiologic bacteria and beta-lactamase-producing bacteria in acute and chronic maxillary sinusitis at Phramongkutklao Hospital.

BACKGROUND: To date, there is an increasing trend of prescribing antibiotics that cover beta-lactamase-producing bacteria as the first line drug for sinusitis patients in Thailand This practice dose not only increases the treatment cost but might also induce resistance to antimicrobial agents. OBJECTIVE: To determine the prevalence of the pathogenic bacteria in acute and chronic maxillary sinusitis as well as the prevalence of beta-lactamase-producing bacteria. MATERIAL AND METHOD: The maxillary aspiration fluid specimens of 52 acute and chronic sinusitis patients at Phramongkutklao Hospital, Bangkok, Thailand during May 2002-May 2003, were collected. Aerobic and anaerobic cultures were performed and the beta-lactamase activities of isolated bacteria were determined. RESULTS: Of 58 specimens, 44 (75.9%) and 14 (24.1%) specimens were collected from acute and chronic maxillary sinusitis patients, respectively. Of 44 specimens of acute maxillary sinusitis, the predominant isolates were Haemophilus influenzae (13, 29.5%), Streptococcus pneumoniae (4, 9%), Streptococcus viridan (4, 9%), and Klebsiella pneumoniae (4, 9%). 6 (13.6%) of them were beta-lactamase-producing bacteria. Of 14 specimens of chronic maxillary sinusitis, the predominant isolates were Pseudomonas aeruginosa (3, 16.6%), Staphylococcus spp (3, 17.5%) and Streptococcus spp. (2, 11.6%). 1 (7.1%) Haemophilus influenza isolate from this group was beta-lactamase-producing bacteria. The percentage of anaerobe was 8.9%, 23.3% for acute and chronic maxillary sinusitis, respectively. CONCLUSION: The present study was indicated that the common organisms in acute maxillary sinusitis were Haemophilus influenzae and Streptococcus pneumoniae, Streptococcus viridians which were similar to a previous study. But the authors found an increased prevalence of anaerobe bacteria in acute maxillary sinusitis and also found beta-lactamase-producing bacteria, 21.4% Hemophilus influenzae less than the previous studies (which found beta-lactamase-producing bacteria around 50% to 70%). The authors found 23.3% anaerobe bacteria in the chronic maxillary sinusitis, less than the previous studies, and the authors also found 8.9% anaerobe in acute maxillary sinusitis.

The correlation of micro-organisms between tonsillar crypt culture and tonsillar core culture in chronic tonsillitis.

OBJECTIVES: This study was undertaken to seek the correlation between tonsillar core and tonsillar crypt cultures and study the incidence of beta- lactamase producing bacteria (BLPB) in chronic tonsillitis patients. MATERIAL AND METHOD: The study was carried out in Department of Otolaryngology from Feb 2000 to Dec 2001. Patients with chronic tonsillitis who underwent tonsillectomy were enrolled, and culture results from tonsillar crypts were compared with tonsillar core. RESULTS: The tonsil were removed from 61 patients. Age ranging from 2-14 years (n=21) and 15-50 years (N= 40); H. influenza (25.2%), S. aureus (23.4%), and S. viridian (11.3%) were isolated from tonsillar core, while 25.9% and 24% of organisms isolated from tonsillar crypt were H. influenza and S. aurieus, respectively. Correlations between tonsillar core and tonsillar crypt culture were 100% specificity for Group A beta hemolytic streptococcocus (GABHS), 86.2% for H. influenza and 81.5% for S. aureus. Regarding beta-lactamase production, 29.2% of H. influenza were beta lactamase producing bacteria (BLPB), while 88.9% of S. aureus were BLPB. CONCLUSION: The present study demonstrates a high correlation in cultures obtained from tonsillar crypt and tonsillar core. The difference in isolated technique may account for the higher correlation when compared to previous studies. The incidence of beta- lactamase producing bacteria in chronic tonsillitis was high.