Retrospective clinical and epidemiological analysis of scorpionism at a referral hospital for the treatment of accidents by venomous animals in Alagoas State, Northeast Brazil, 2007-2017.

Scorpionism has a high incidence rate in Brazil. It is considered a serious public health problem mainly in tropical and subtropical regions around the world. The number of scorpion accidents have increased over the years and the highest frequencies have been reported mainly in the Brazilian Northeast region. Therefore, in this study we report a retrospective clinical and epidemiological analysis of scorpion stings from 2007 to 2017 in Alagoas State, Northeast Brazil, at a referral hospital for assistance and treatment of accidents by venomous animals. During the analyzed period, the referral hospital treated 27,988 cases, and an increase in the number of cases has taken place over the years. The highest frequency of scorpion stings was observed in females, and the age range most affected was from 20 to 29 years old. The most stung body site was the foot, followed by finger, toe or hand. Regarding the severity, most severe cases were reported in children up to 4 years old (69.4%) and 50% of the total cases treated with serotherapy corresponded to patients in this age range. Interestingly, it was also found that the occurrence of systemic manifestations and the severity of the cases were significantly associated with pediatric patients. In this way, this study highlights the scorpionism as an environmental public health problem in Alagoas State, Northeast Brazil, as well as the need to intensify the epidemiological surveillance and educational campaigns to prevent and control scorpion accidents throughout the year.

Use of induced pluripotent stem cells (iPSCs) and cerebral organoids in modeling the congenital infection and neuropathogenesis induced by Zika virus.

Infection with Zika virus (ZIKV) was recently demonstrated to be associated with damage to the central nervous system, especially microcephaly and the Guillain-Barré syndrome. This finding had alarmed public health agencies and mobilized institutions around the world to search for more information about the virus, its effects, pathophysiological mechanisms, and potential immunizations and treatments. Given the increasing interest in using iPSCs and cerebral organoids to model the congenital infection and neuropathogenesis induced by ZIKV, the aim of this review was to present an up-to-date summary of the publications on the association of ZIKV with microcephaly, using iPSCs and organoids. According to our review, the number of studies has decreased concomitantly with a decrease in the number of cases. The presence of subclinical lesions at birth, which may eventually present cognitive or behavioral problems in the future, suggests that persistent research efforts on the virus should be undertaken by the global health community till the threat is completely wiped out.

Spread of Chikungunya Virus East/Central/South African Genotype in Northeast Brazil.

We investigated an outbreak of exanthematous illness in Maceió by using molecular surveillance; 76% of samples tested positive for chikungunya virus. Genetic analysis of 23 newly generated genomes identified the East/Central/South African genotype, suggesting that this lineage has persisted since mid-2014 in Brazil and may spread in the Americas and beyond.

Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil.

Few studies, each limited to a single major city, have investigated the prevalence and seasonal patterns of different viruses among children with low respiratory tract infections (LRTI) in Northeastern Brazil. The aim of this study was to determine the frequency of respiratory syncytial virus (RSV) and of 7 other viruses in children for LRTI in 4 capitals from this region, and investigate their association with several risk factors, including meteorological data. From April 2012 to March 2013, 507 children, aged up to 24 months and hospitalized with LRTI in one of the participating centers at Aracajú, Salvador, Recife, and Maceió, had a sample of nasopharyngeal aspirate collected and analyzed for the following viruses by reverse-transcription polymerase chain reaction followed by hybridization on low-density microarrays: RSV, influenza, parainfluenza, adenovirus, rhinovirus, metapneumovirus, bocavirus, and coronavirus. The result was positive in 66.5% of cases, RSV was the most common virus (40.2%). Except for rhinovirus (17%), all other virus had frequency rates lower than 6%. Viral coinfections were detected in 13.8% of samples. Possible related risk factors for RSV infection were low age upon entry, attendance of daycare, low gestational age, and low educational level of the father. The relative frequency of viral infections was associated with increasing temperature and decreasing humidity separately, but the results also suggested both associated with increased frequency of RSV. Some of these findings differ from those reported for other regions in Brazil and may be used to guide policies that address LRTI.

Prevalence of syphilis, human immunodeficiency virus, hepatitis B virus, and human T-lymphotropic virus infections and coinfections during prenatal screening in an urban Northeastern Brazilian population.

OBJECTIVES: To evaluate prevalences of Treponema pallidum, human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), and hepatitis B virus (HBV) infections and coinfections during prenatal screening in an urban Northeastern Brazilian population through a large dataset. METHODS: Secondary data were obtained from the Maceió (Alagoas, Brazil) municipal prenatal screening program from June 2007 to May 2012. Dried blood serum tests from 54,813 pregnant women were examined to determine prevalences of T. pallidum, HIV, HTLV, and HBV infections and coinfections, and the seroconversion rates for syphilis and HIV infection. Socio-demographic variables associated with syphilis and HIV infection were identified. RESULTS: The prevalences of syphilis, HIV, HTLV, and HBV infections were 2.8%, 0.3%, 0.2%, and 0.4%, respectively. Pregnant women infected with T. pallidum had a 4.62-fold greater risk of HIV coinfection, and pregnant women infected with HIV had a 5.71-fold greater risk of T. pallidum coinfection. Seroconversion for syphilis and HIV during pregnancy occurred in 0.5% and 0.06% of women, respectively. Among the women carrying HTLV, 4.2% also had an HBV infection. CONCLUSIONS: Syphilis was twice as prevalent among pregnant women in Maceió, compared to the national average, and coinfections with syphilis/HIV and HTLV/HBV were significantly associated among these pregnant women.

[Prevalence of overweight and obesity in children and adolescents from the city of Maceió (AL)]. / Prevalência de sobrepeso e obesidade em crianças e adolescentes da cidade de Maceió.

OBJECTIVE: To establish prevalence of overweight and obesity in children and adolescents from the city of Maceió, Alagoas, Brazil, and investigate the association of risk of overweight and obesity with gender, age and type of school. METHODS: This was a cross-sectional study. Students between 7 and 17 years of age were selected from 396 public and private schools of Maceió. After randomization, data were collected by questionnaire. Weight and height were measured (body mass index = weight:height2). Overweight and obesity were defined, respectively, as body mass index greater than the 85th percentile and equal or greater than the 95th percentile for age and gender. RESULTS: The final sample included 1253 students (706 females). One hundred sixteen students were overweight and fifty six students were obese. Obesity was significantly associated with students between 7 and 9 years of age, when compared to the 10 and 13 year olds (p<0.04) and the 14 and 17 year olds (p<0.02). Private school students were more likely to be overweight (OR=2.2; CI95%:1.36 - 3.32) and more likely to be obese (OR=4.7; CI95%:2.32 - 9.34) than students CONCLUSION: The prevalence of overweight and obesity were, respectively, 9.3% and 4.5%. Overweight and obesity were significantly more frequent among private school students.

Prevalência de sobrepeso e obesidade em crianças e adolescentes da cidade de Maceió / Prevalence of overweight and obesity in children and adolescents from the city of Maceió (AL)

OBJETIVO: Estabelecer a prevalência de sobrepeso e obesidade em crianças e adolescentes de Maceió (Alagoas, Brasil) e verificar associação destes fatores com gênero, idade e tipo de escola. MÉTODOS: Estudo epidemiológico descritivo, transversal. Avaliou jovens de 7 a 17 anos de idade, sorteados das 396 escolas públicas e particulares de Maceió. Após a randomização, os dados foram coletados por meio de questionário e medidas antropométricas (Índice de Massa Corporal = peso: altura²). Sobrepeso e obesidade foram definidos como Índice de Massa Corporal superior ao percentil 85 e igual ou superior ao percentil 95 para idade e sexo, respectivamente. RESULTADOS: A amostra final foi constituída de 1253 estudantes (706 do gênero feminino). Identificados 116 estudantes com sobrepeso e 56 estudantes com obesidade. Houve associação significante entre obesidade e estudantes com idade de sete a nove anos quando comparados com os de 10 a 13 anos (p<0,04) e com os de 14 a 17 anos (p<0,02). Estudantes das escolas particulares apresentaram o dobro de chance de terem sobrepeso (OR=2,2; IC95 por cento:1,36-3,32) e aproximadamente cinco vezes mais chances de apresentarem obesidade (OR=4,7; IC95 por cento:2,32-9,34) em relação aos das escolas públicas. CONCLUSÃO: As prevalências do sobrepeso e obesidade foram de 9,3 por cento e 4,5 por cento respectivamente, sendo significantemente mais elevadas em estudantes das escolas particulares.

OBJECTIVE: To establish prevalence of overweight and obesity in children and adolescents from the city of Maceió, Alagoas, Brazil, and investigate the association of risk of overweight and obesity with gender, age and type of school. METHODS: This was a cross-sectional study. Students between 7 and 17 years of age were selected from 396 public and private schools of Maceió. After randomization, data were collected by questionnaire. Weight and height were measured (body mass index = weight:height2). Overweight and obesity were defined, respectively, as body mass index greater than the 85th percentile and equal or greater than the 95th percentile for age and gender. RESULTS: The final sample included 1253 students (706 females). One hundred sixteen students were overweight and fifty six students were obese. Obesity was significantly associated with students between 7 and 9 years of age, when compared to the 10 and 13 year olds (p<0.04) and the 14 and 17 year olds (p<0.02). Private school students were more likely to be overweight (OR=2.2; CI95 percent:1.36 - 3.32) and more likely to be obese (OR=4.7; CI95 percent:2.32 - 9.34) than students CONCLUSION: The prevalence of overweight and obesity were, respectively, 9.3 percent and 4.5 percent. Overweight and obesity were significantly more frequent among private school students.

[Prevalence of cardiovascular risk factors in child and adolescent students in the city of Maceió]. / Prevalência de fatores de risco cardiovascular em crianças e adolescentes da rede de ensino da cidade de Maceió

OBJECTIVE: To determine the prevalence of systemic arterial hypertension (SAH), "risk of overweight," overweight, sedentary lifestyle, and smoking in children and adolescents from 7 to 17 years of age, of both sexes, in public and private schools in the city of Marceió, in the state of Alagoas. METHODS: A cross-sectional epidemiological study with sampling from a population pool was carried out. It comprised elementary and middle schools, randomly selected. The sample was calculated based on the expected lower prevalence of the variables studied. The assessment protocol comprised a structured questionnaire, anthropometry, and blood pressure measurements. The chi-square test was used to analyze the association among variables. RESULTS: In 2001, 1,253 students (547 of the male sex; mean age, 12.4+/-2.9 years) were assessed. The results were as follows: 1.172 students participated in no moderate to intense physical activity; "risk of overweight" and overweight were present in 116 and 56 individuals, respectively; blood pressure in the > or = 95th percentile was identified in 97 students; and only 30 students admitted smoking regularly. The following significant associations were observed: "risk of overweight" and overweight in private school students (*P=0.0001) and sedentary lifestyle in the female sex (*P=0.0001). CONCLUSION: The prevalence of a sedentary lifestyle, "risk of overweight," overweight, systemic arterial hypertension, and smoking in the population studied was 93.5%, 9.3%, 4.5%, 7.7%, and 2.4%, respectively.

Prevalência de fatores de risco cardiovascular em crianças e adolescentes da rede de ensino da cidade de Maceió / Prevalence of cardiovascular risk factors in child and adolescent students in the city of Maceió

OBJETIVO: Estabelecer a prevalência de hipertensão arterial sistêmica (HAS), do "risco de sobrepeso", sobrepeso, sedentarismo e tabagismo em crianças e adolescentes, de 7 a 17 anos, de ambos os sexos, da rede pública e privada de ensino de Maceió, AL. MÉTODOS: Estudo epidemiológico transversal. Amostragem por conglomerados em escolas de nível fundamental e médio. Cálculo da amostra baseado na menor prevalência esperada das variáveis estudadas. Protocolo de avaliação: questionário estruturado, antropometria e medidas da pressão arterial. Análise de associação das variáveis realizada pelo método do qui-quadrado. RESULTADOS: Em 2001 foram avaliados 1253 estudantes (547 do sexo masculino, média de idade 12,4±2,9 anos), demonstrando-se que 1172 não praticavam atividade física de moderada a intensa; "risco de sobrepeso" e sobrepeso presentes em 116 e 56 indivíduos, respectivamente; pressão arterial no percentil > de 95 identificada em 97 estudantes e apenas 30 admitiram fumar regularmente. Observou-se associação significante do "risco sobrepeso" e do sobrepeso com estudantes de escolas particulares (*p=0,0001) e do sedentarismo com o sexo feminino (*p=0,0001). CONCLUSAO: A prevalência de sedentarismo, "risco de sobrepeso", sobrepeso, hipertensão arterial sistêmica e tabagismo na população estudada foi de 93,5 por cento; 9,3 por cento; 4,5 por cento; 7,7 por cento e 2,4 por cento, respectivamente.