Interaction Effects of FTO and MC4R Polymorphisms on Total Body Weight Loss, Post-Surgery Weight, and Post-Body Mass Index after Bariatric Surgery.

Bariatric surgery (BS) is considered the most effective intervention for patients with severe obesity and is used to maintain long-term weight loss and glycemic control. The aim of this study was to analyze the effects of genotypes and haplotypes of the fat mass and obesity-associated (FTO) and melanocortin 4 receptor (MC4R) genes on total body weight loss (TBWL), post-surgery weight, and post-BMI after bariatric surgery. We retrospectively selected 101 patients from Bajio High Specialty Regional Hospital, León Guanajuato, México, who underwent Roux-en-Y gastric bypass (RYGB) to determine their body mass index (BMI), blood pressure, biochemical characteristics, and comorbidities. Post-surgery, patients were referred for registered anthropometry and blood pressure. Glucose, lipid and hepatic profiles, and insulin, leptin, and ghrelin levels were measured, and rs9939609, rs9930506, and rs1421085 FTO and rs17782313 MC4R polymorphisms were genotyped. Six (4-8) years after BS, post-surgery weight was greater in carriers of the rs9939609 and rs1421085 risk genotypes. TBWL was lower for the rs9930506 and rs1421085 risk genotypes. Insulin and HOMA-IR were greater in patients with the three FTO polymorphisms. There were significant interaction effects of the rs9930506 and rs1421085 FTO risk genotypes on weight and BMI in response to BS. No association was found with the MC4R polymorphism. The genotypes and haplotypes of the FTO gene influence post-surgery weight, TBWL, insulin levels, and HOMA-IR.

Analysis of Factors Associated with Outcomes of Bariatric Surgery: rs1800497 ANKK1, rs1799732 DRD2 Genetic Polymorphisms, Eating Behavior, Hedonic Hunger, and Depressive Symptoms.

INTRODUCTION: A therapeutic approach to severe obesity is bariatric surgery (BS), which is considered an effective intervention for ameliorating comorbidities such as T2DM, hypertension, dyslipidemia, and cardiovascular diseases. Some polymorphisms are considered markers for addictive disorders and hedonic hunger. We analyzed factors associated with the outcomes of BS, including rs1800497 ANKK1 and rs1799732 DRD2 polymorphisms, eating behavior, hedonic hunger, and depressive symptoms. METHODS: We retrospectively selected 101 patients who underwent BS and agreed to participate. The previous conditions to BS, such as body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), and comorbidities, were registered; the scholarship value was evaluated as the total number of years of scholarly education. To evaluate the post-surgery conditions of the participants, we took blood samples, anthropometric measures, and 3 questionnaires to evaluate eating behavior (TFEQ-R18), hedonic hunger (PFS), and depressive symptoms (PHQ-9). The ANKK1 rs1800497 and rs1799732 DRD2 polymorphisms were genotyped. RESULTS: The median total weight loss (TWL) was 34.7 kg, with a BMI of 33.8 kg/m2, 6 (4-8) years after BS. The TWL was positively associated with the TFEQ-R18 score (p = 0.006) and negatively associated with triglycerides (p = 0.011). rs1800497 ANKK1 was associated with TFEQ-R18 (OR = 1.13 (1.02-1.25), p = 0.009). We also found a negative correlation of pre-surgery BMI with scholarship (r = - 0.27, p < 0.05). CONCLUSION: The patients showed an improvement in metabolic and anthropometric parameters post-surgery. Interestingly, the ANKK1 Taq1A polymorphism was associated with eating behavior and scholarship with pre-surgery BMI, which may be considered predictors of BS outcomes.

[Type 2 diabetes mellitus could predict a sub-optimal weight loss after bariatric surgery]. / Diabetes mellitus tipo 2 podría predecir una pérdida subóptima de peso después de una cirugía bariátrica.

INTRODUCTION: bariatric surgery does not benefit all patients. Identifying severely obese patients who will succeed after bariatric surgery remains a challenge for the transdiciplinary team. The objective of this retrospective study was to analyze preoperative dietary factors that could predict a successful weight loss after bariatric surgery. METHODS: the retrospective study included patients undergoing laparoscopic Roux-en-Y gastric bypass surgery as a procedure for severe obesity (n = 84). Patient demographics, comorbidities, dietary factors, and weight loss results were extracted from the electronic medical record. RESULTS: type 2 diabetes mellitus (DM2) was associated with suboptimal weight loss after laparoscopic Roux-en-Y gastric bypass surgery. CONCLUSIONS: although bariatric surgery continues being the most effective treatment for patients with severe obesity, developing strategies to improve and maintain weight loss, especially in patients with DM2, is fundamental. Assessing the dietary characteristics of candidates for bariatric surgery is crucial.

INTRODUCCIÓN: la cirugía bariátrica no beneficia a todos los pacientes. Identificar a los pacientes gravemente obesos que tendrán éxito después de la cirugía bariátrica sigue siendo un reto para el equipo transdiciplinario. El objetivo de este estudio retrospectivo fue analizar factores dietéticos preoperatorios que pudieran predecir una pérdida de peso exitosa después de la cirugía bariátrica. MÉTODOS: el estudio retrospectivo incluyó a pacientes sometidos a una cirugía de bypass gástrico laparoscópico en Y de Roux como procedimiento para obesidad severa (n = 84). Datos demográficos del paciente, comorbilidades, factores dietéticos y los resultados de pérdida de peso se extrajeron de la historia clínica electrónica. RESULTADOS: la diabetes mellitus tipo 2 (DM2) se asoció con una pérdida subóptima de peso después de una cirugía de bypass gástrico laparoscópicoen Y de Roux. CONCLUSIONES: aunque la cirugía bariátrica sigue siendo el tratamiento más efectivo para los pacientes con obesidad severa, es fundamental desarrollar estrategias para mejorar y mantener la pérdida de peso, especialmente en pacientes con DM2. Evaluar las características dietéticas de los candidatos a cirugía bariátrica es crucial.

Diabetes mellitus tipo 2 podría predecir una pérdida subóptima de peso después de una cirugía bariátrica / Type 2 diabetes mellitus could predict a sub-optimal weight loss after bariatric surgery

Introducción: la cirugía bariátrica no beneficia a todos los pacientes. Identificar a los pacientes gravemente obesos que tendrán éxito después de la cirugía bariátrica sigue siendo un reto para el equipo transdiciplinario. El objetivo de este estudio retrospectivo fue analizar factores dietéticos preoperatorios que pudieran predecir una pérdida de peso exitosa después de la cirugía bariátrica. Métodos: el estudio retrospectivo incluyó a pacientes sometidos a una cirugía de bypass gástrico laparoscópico en Y de Roux como procedimiento para obesidad severa (n = 84). Datos demográficos del paciente, comorbilidades, factores dietéticos y los resultados de pérdida de peso se extrajeron de la historia clínica electrónica. Resultados: la diabetes mellitus tipo 2 (DM2) se asoció con una pérdida subóptima de peso después de una cirugía de bypass gástrico laparoscópicoen Y de Roux. Conclusiones: aunque la cirugía bariátrica sigue siendo el tratamiento más efectivo para los pacientes con obesidad severa, es fundamental desarrollar estrategias para mejorar y mantener la pérdida de peso, especialmente en pacientes con DM2. Evaluar las características dietéticas de los candidatos a cirugía bariátrica es crucial

Introduction: bariatric surgery does not benefit all patients. Identifying severely obese patients who will succeed after bariatric surgery remains a challenge for the transdiciplinary team. The objective of this retrospective study was to analyze preoperative dietary factors that could predict a successful weight loss after bariatric surgery. Methods: the retrospective study included patients undergoing laparoscopic Roux-en-Y gastric bypass surgery as a procedure for severe obesity (n = 84). Patient demographics, comorbidities, dietary factors, and weight loss results were extracted from the electronic medical record. Results: type 2 diabetes mellitus (DM2) was associated with suboptimal weight loss after laparoscopic Roux-en-Y gastric bypass surgery. Conclusions: although bariatric surgery continues being the most effective treatment for patients with severe obesity, developing strategies to improve and maintain weight loss, especially in patients with DM2, is fundamental. Assessing the dietary characteristics of candidates for bariatric surgery is crucial