[The Multicenter Captopril and the Quality of Life Study: the effect of antihypertensive agents from the basic groups on the quality of life of patients in different populations. The working group of the Multicenter Captopril and the Quality of Life Study]. / Mnogotsentrovoe issledovanie "Kaptopril i kachestvo zhizni": vliianie antigipertenzivnykh sredstv osnovnykh grupp na kachestvo zhizni bol'nykh iz razlichnykh populiatsii. Rabochaia gruppa mnogotsentrovogo issledovaniia "Kaptopril i kachestvo zhizni".

This multicenter trial included 205 males aged 30-60 years with stable mild and moderate hypertension. 140 patients were from Moscow (140 patients), St. Petersburg, Kursk, Rostov (Russia); Kharkov, Donetsk (Ukraine); Baku (Azerbaijan). Group 1 patients received captopril, group 2 nifedipine, group 3 hydrochlorothiazide, group 4 propranolol.

[The effect of long-term monotherapy with preparations from the 4 basic groups of antihypertensive agents on the quality of life in patients with mild and moderate arterial hypertension. The Multicenter Captopril and the Quality of Life Study. The working group of the Multicenter Captopril and the Quality of Life Study]. / Vliianie dlitel'noi monoterapii preparatami iz chetyrekh osnovnykh grupp antigipertenzivnykh sredstv na kachestvo zhizni bol'nykh miagkoi i umerennoi arterial'noi gipertoniei. Mnogotsentrovoe issledovanie "Kaptopril i kachestvo zhizni". Rabochaia gruppa mnogotsentrovogo issledovaniia "Kaptopril i kachestvo zhizni".

A multicenter, controlled, open, randomized trial of antihypertensive and life quality (LQ) effects of monotherapy with captopril vs propranolol, hydrochlorothiazide and nifedipine included 345 males aged 35-60 years with mild and moderate hypertension. The results of 8-month treatment provided the conclusions: the drugs were much alike by antihypertensive efficacy, LQ parameters proved more beneficial in the group on captopril than those on nifedipine and propranolol, hydrochlorothiazide failed to improve life quality, captopril is an effective and safe antihypertensive drug superior to the drugs of 3 other antihypertensive drug groups by positively affecting LQ.