RESUMO
A double-blind trial in 80 patients showed no significant difference in the efficacy, tolerance and safety for intravenous urography between the new contrast medium Ioversol (Optiray Mallinckrodt Inc.) and the well established medium Iohexol (Omnipaque, Nycomed [UK] Ltd). Minor transient rises in AST/ALT were noted in approximately 10% of each group which were regarded as clinically insignificant. Both media were well tolerated with no significant side-effects.
Assuntos
Meios de Contraste , Iohexol , Ácidos Tri-Iodobenzoicos , Urografia/métodos , Adulto , Idoso , Alanina Transaminase/sangue , Aspartato Aminotransferases/sangue , Meios de Contraste/efeitos adversos , Método Duplo-Cego , Humanos , Iohexol/efeitos adversos , Pessoa de Meia-Idade , Ácidos Tri-Iodobenzoicos/efeitos adversosRESUMO
The alpha 1-antitrypsin phenotype PiMZ has been reported to have a higher than normal incidence in patients with acute anterior uveitis, indicating an important role in the immunogenetics of this condition. We have determined the incidence of this phenotype in 72 patients with acute anterior uveitis. It was found to occur in four patients (5.6% of the total), with the highest incidence (3/34 or 8.8%, p less than 0.001) in patients negative for HLA B27 and without sacroiliac joint disease. The incidence in HLA B27 positive patients was normal. No correlation was found with the severity, bilaterality, or recurrence of uveitis. Although this increased incidence is statistically significant in comparison with the normal population incidence of 2.6%, its direct clinical significance is questionable; the most likely explanation for it includes possible linkage with other immunoregulatory genes. We also found a lower than expected incidence of the phenotype PiMS, and discuss the relevance of this finding.
Assuntos
Uveíte Anterior/genética , Deficiência de alfa 1-Antitripsina , Adolescente , Adulto , Idoso , Feminino , Antígenos HLA/genética , Antígeno HLA-B27 , Humanos , Masculino , Pessoa de Meia-Idade , Fenótipo , Articulação Sacroilíaca , Espondilite Anquilosante/complicações , Espondilite Anquilosante/enzimologia , Uveíte Anterior/complicaçõesRESUMO
The case of a middle aged woman who presented with fibrosing alveolitis, in her mid-forties, followed by a sicca syndrome and who subsequently developed a pulmonary lymphoma (B cell) while receiving azathioprine therapy is recorded. Of interest was the absence of polyclonal B cell activation, e.g., production of rheumatoid factor, hypergammaglobulinaemia, high titre antinuclear antibodies or antibodies to extractable nuclear antigens (ENA) during most of her illness. Persistently raised IgM levels and low IgA levels were demonstrated. The relevance of azathioprine to development of the lymphoma is discussed.