RESUMO
It is generally believed that patients operated on for gross obesity with jejunoileal shunt develop electrolyte malabsorption. In follow-up studies electrolyte abnormalities have been reported in 6-37% of the cases. We have not been able to find any description of simple diagnostic tools to help indicate which patients should be treated with electrolyte supplements. The aim of this study was to evaluate different diagnostic tools to determine whether they would identify which patients to treat. Ten patients with end-to-side jejunoileostomies were investigated. Our attempt failed. We were not able to identify the patients who needed supplementary therapy. The reason for this may be absence of severe electrolyte abnormalities or insufficient diagnostic methods.
Assuntos
Derivação Jejunoileal/efeitos adversos , Deficiência de Magnésio/etiologia , Feminino , Seguimentos , Humanos , Hipocalcemia/etiologia , Masculino , Deficiência de Potássio/etiologiaRESUMO
Magnesium deficiency is often secondary to existing disease. Over a period of 20 years, 17 cases of primary magnesium-losing kidney have been reported. This report describes two additional cases, and a comparison with previous cases is made. The familial magnesium-losing kidney appears to be caused by a congenital tubular defect in the reabsorption of magnesium. Its manifestations may be various but the diagnosis is established by the presence of hypomagnesemia with an unappropriately high urinary magnesium excretion in patients with no other renal disorder.
Assuntos
Túbulos Renais Distais/metabolismo , Túbulos Renais/metabolismo , Deficiência de Magnésio/etiologia , Adulto , Feminino , Humanos , Magnésio/metabolismo , Deficiência de Magnésio/diagnóstico , Deficiência de Magnésio/genética , Masculino , Pessoa de Meia-IdadeRESUMO
The indirect pancreatic function test, the fluorescein dilaurate test, was performed twice on nine healthy volunteers. The test is based on the renal excretion of fluorescein liberated from an ingested fluorescein ester by pancreatic enzymes. As a control, fluorescein sodium was ingested under similar conditions. The results of the test are expressed as the ratio of the amount of fluorescein excreted in the test part and the control part, forming the test/control (T/C) ratio. The mean values of excreted fluorescein correlated well with those reported by other authors. The coefficient of variation was 35% in the repeated test and of the same order in the series of individuals. The test cannot be recommended as a quantitative test until further investigation has been performed. Its use as a screening test is found questionable.
Assuntos
Fluoresceínas , Testes de Função Pancreática/métodos , Adulto , Feminino , Fluoresceínas/urina , Humanos , Masculino , Fatores de TempoRESUMO
Nuclei, isolated from polyoma virus-infected mouse 3T6 cells, were incubated under condtions suitable for polyoma DNA synthesis. By using electrom microscopy and standard regression statistics, it was shown that replication is mainly unidirectional in a large number of molecules, indicating the presence of inactive replication forks. The replication forks were inactivated randomly, and the defect seemed to be present from the beginning of the in vitro incubation.
