Inflammatory mechanisms contributing to retinal alterations in HIV infection and long-term ART.

People living with HIV (PLWH) may face an increased risk of eye complications associated with ageing, chronic inflammation, and the toxicity arising from long-term antiretroviral therapy (ART). This review aims to understand how inflammatory pathways contribute to retinal alterations observed in PLWH on long-term ART. This review was conducted using four electronic database searches, namely Scopus, Hinari, Google Scholar, and PubMed; from 1996 (when ART became available) until January 2022, without language restriction. Sources from clinical trials, meta-analyses, randomised controlled trials, and systematic reviews were used. Dysregulated para-inflammation (chronic inflammation) damages the blood-retina barrier, resulting in the altered retinal immune privilege and leading to the development of retinal and blood vessel changes. There is an interplay between the effects of the disease versus ART. ART causes mitochondrial toxicity, which affects the retinal ganglion cells and retinal pigment epithelium (RPE) due to oxidative stress. Infection by HIV also affects retinal microglia, which contributes to RPE damage. Both of these mechanisms affect the blood vessels. Assessing the integrity of the inner and outer blood-retina barrier is a pivotal point in pinpointing the pathogenesis of inner retinal alterations. Optical coherence tomography is a valuable tool to assess these changes. There is a paucity of research to understand how these structural changes may affect visual function, such as contrast sensitivity and colour vision.

Utilisation pattern of ophthalmic services in Ashanti Region, Ghana.

BACKGROUND:  Best practice in optometry and ophthalmology recommends regular visits to eye care professionals, as routine eye examinations support early detection of ocular defects and associated systemic, sometimes potentially life-threatening, conditions. AIM:  The study sought to determine the utilisation of ophthalmic services and its associated factors in the Ashanti region of Ghana. SETTING:  Fifty electoral areas in 10 of the 43 districts in the Ashanti region of Ghana. METHODS:  A total of 1615 participants, aged 18 years and above, were randomly selected in the Ashanti region of Ghana for this population-based, cross-sectional survey. The factors associated with having had an eye examination were guided by Andersen's Behavioural Model. The data were analysed using multiple logistic regression, employing the IBM SPSS software, version 25. RESULTS:  After statistical adjustments, compared with the 18-29-year-old age group, older participants were found to be more likely to utilise eye care services: In addition, participants with higher formal education had higher odds for eye care utilisation compared with no former education: Being hypertensive, self-reported vision problems and feeling that regular eye examinations are important, were statistically associated with eye care utilisation. CONCLUSION:  There is alarmingly poor utilisation of ophthalmic services in the Ashanti region of Ghana. Effective programmes to promote public health by addressing the socio-economic and individual barriers hindering the uptake of ophthalmic services in the Ashanti region of Ghana are thus necessary.Contribution: The study addresses a gap in the knowledge of factors associated with ophthalmic services utilisation in the Ashanti region of Ghana.

Ophthalmic services utilisation and associated factors in the Ashanti region, Ghana.

Objective: This survey determined the utilisation of eye care services and associated factors among adults in the Ashanti region of Ghana. Design: A population-based cross-sectional descriptive study. Method: Data for this study was collected from 1615 randomly selected individuals in the Ashanti region of Ghana, using a structured, pretested interviewer-guided questionnaire. Information regarding the accessibility and determinants of, and barriers to, eye care services was based on self-reports, using the WHO Eye Care Services Assessment Questionnaire. Inferential analyses were performed using the chi-square test for statistical significance, set at p=0.05. Setting: Ashanti Region, Ghana. Participants: One thousand six hundred and fifteen randomly selected adults. Results: Public eye care facilities were used by 58.2% of the participants for their last eye exam. Of the participants, 47.0% had travelled less than five kilometres for their last eye exam. Waiting time and service cost were participants' most frequently cited challenges in seeking care. No need felt (40.1%), self-medication (37.7%) and cost (22.2%) were the most frequently mentioned barriers to seeking ophthalmic services. Conclusion: The major challenges encountered in seeking eye care services were waiting time and cost of service. Major barriers to ophthalmic services utilisation were no need felt, self-medication and cost. Factors such as cost, lack of felt need and self-medication, which serve as barriers to utilising eye care services, should be addressed by stake-holders through eye health education and promotion. Funding: None declared.

Ophthalmic services utilisation and associated factors in the Ashanti region, Ghana

Objective: This survey determined the utilisation of eye care services and associated factors among adults in the Ashanti region of Ghana. Design: A population-based cross-sectional descriptive study Method: Data for this study was collected from 1615 randomly selected individuals in the Ashanti region of Ghana, using a structured, pretested interviewer-guided questionnaire. Information regarding the accessibility and determinants of, and barriers to, eye care services was based on self-reports, using the WHO Eye Care Services Assessment Questionnaire. Inferential analyses were performed using the chi-square test for statistical significance, set at p=0.05.Setting: Ashanti Region, Ghana Participants: One thousand six hundred and fifteen randomly selected adults Results: Public eye care facilities were used by 58.2% of the participants for their last eye exam. Of the participants, 47.0% had travelled less than five kilometres for their last eye exam. Waiting time and service cost were participants' most frequently cited challenges in seeking care. No need felt (40.1%), self-medication (37.7%) and cost (22.2%) were the most frequently mentioned barriers to seeking ophthalmic services. Conclusion: The major challenges encountered in seeking eye care services were waiting time and cost of service. Major barriers to ophthalmic services utilisation were no need felt, self-medication and cost. Factors such as cost, lack of felt need and self-medication, which serve as barriers to utilising eye care services, should be addressed by stakeholders through eye health education and promotion

The Effect of Home-Based Dichoptic Therapy on Young Adults with Non-Strabismic Anisometropic Amblyopia on Stereo Acuity.

Aim: To evaluate the effect of home-based dichoptic visual therapy using anaglyphic red-green filters on the stereo acuity in a sample of young adults with non-strabismic anisometropic amblyopia. Methods: The study was observational and cross-sectional in design. Two groups (experimental vs control) were sourced using purposive sampling of young adults with non-strabismic amblyopia (experimental group) in comparison to an age-match control group without amblyopia. For the purpose of refractive adaptation, all participants in both groups were asked to wear their spectacle correction constantly for at least 16 weeks prior to exposure to home-based dichoptic therapy. Stereo acuity measurements using the Stereo Fly test were obtained before and after 40 hours exposure to home-based dichoptic therapy. The changes in stereo acuity post eight weeks (40 hours) training from baseline measurements was obtained. The difference in medians between the experimental and control groups using the Mann-Whitney U-test was measured with significance set at P value of <0.05. Results: A total of 38 young adults (19 males, 19 females) with a mean age of 24.05 ± 5.66 years were enrolled in this study. Nineteen anisometropic amblyopes comprised the experimental group, fifteen of which were classified as moderate amblyopia (6/12-6/36) and 19 non-amblyopes comprised the control group. Home-based dichoptic therapy used on the experimental group after 8 weeks showed a significant improvement in stereo-acuity with a mean improvement of 345.26 ± 184.85 sec arc-1 [IQR:260;600; p<0.001] when compared to the control group. Conclusion: Home-based dichoptic therapy improved stereo-acuity in non-strabismic anisometropic amblyopes (moderate) in young adults. Thus suggesting that binocularity can improve in anisometropic adult amblyopes with a treatment modality that may be a convenient option better suit the demanding lifestyle of economically active adults who may not be able to comply with clinic-based therapy.

Screen-based behaviour in children is more than meets the eye.

Increased screen time (ST) in children is quickly becoming a public health concern as children are now reliant on technology for social interaction and educational development. The eye-health community has paid considerable attention to this in the recent literature, documenting it as digital eye strain. Continual close eye work and a lack of outdoor play contribute to digital eye strain and today's myopia epidemic. This is a cause for concern for public health stakeholders insofar as it leads to sedentary, screen-based behaviour (SSB) in children. This results in a lack of physical activity and impacts both their bodies and their mental health. The potentially harmful effects of prolonged screen exposure on developing brains and bodies are likely to be unique and significant as physiological growth changes intersect with exponentially expanding e-platforms. While embracing the benefits of a highly digitalised world, we need to simultaneously mitigate the potential risks they pose to the health of growing children.

The relationship between retinal structure and visual function in non-immuno-compromised people living with HIV without retinitis on antiretroviral therapy.

BACKGROUND: This study sought to establish the association between retinal morphology, visual function and linear parameters of cerebral atrophy in non-immunocompromised people living with HIV (NIPLHIV). METHODS: Sixty participants (30 NIPLHIV, 30 controls), aged 18-45 years, were sourced from an outpatient clinic in South Africa. NIPLHIV on antiretroviral therapy (ART) had elevated CD4 counts and low viral loads. Macula thickness and volume measurements were obtained using the Spectralis optical coherence tomographer. Contrast sensitivity (CS), colour vision and visual-evoked potentials (VEP) were also obtained. Linear parameters of cerebral atrophy (Sylvian fissure ratio, SFR) and bicaudate nucleus ratio (BCR) were all acquired from computed tomography (CT) scans. Associations between retinal thickness and volume and visual function were established by principal component factor analysis. RESULTS: CS scores were indirectly associated with the Inner Nuclear Layer (INL)-ETDRS thickness and volume subfields (co-efficient = -0.07; p = 0.02 and -0.11; p = 0.001), respectively. F100 total error scores (TES) were directly associated with the thicknesses of Ganglion Cell Layer-ETDRS subfields (co-efficient = 6.06; p = 0.04) but indirectly associated with INL-ETDRS subfields (co-efficient = -5.49; p = 0.04). F100-TES were indirectly associated with volumes of RNFL (Retinal Nerve Fibre Layer)-ETDRS subfields (co-efficient = -5.54; p = 0.02) and inner retina -ETDRS subfields (co-efficient = -6.70; p = 0.02). P100 latency was directly associated with RNFL-ETDRS subfield thickness (co-efficient = 2.90; p = 0.02) and volumes of outer retina subfields (co-efficient = 2.72; p = 0.04). CS scores were directly associated with SFR (co-efficient = -0.04; p = 0.01). F100-TES were directly associated with BCR (co-efficient = 0.003; p = 0.004) and SFR (co-efficient = 0.002; p = 0.02). P100 latency was indirectly associated with BCR (co-efficient = -0.001; p = 0.03). CONCLUSION: The recognition of associations may be the first step in the proposal to develop a framework for the surveillance of vision in patients with NIPLHIV. We recommend a study of the sample population to track the stability of these observations before general recommendations for clinical care.

The Investigation of the Effect of Hyperglycemic Changes on Psychophysical Measurements of Visual Function in Pseudophakic People Living with Diabetes Mellitus.

PURPOSE: The purpose of this study was to show the effect of increasing blood glucose level (BGL) on psychophysical visual function represents by visual acuity and contrast sensitivity in pseudophakic people living with diabetes (PDM). STUDY DESIGN: This was quasi-experimental, quantitative study using a pretest-posttest approach. METHODS: The study was conducted at Gamalakhe community health centre located in Gamalakhe township and included a sample of 50 pseudophakic people living without diabetes mellitus (PWDM) and 50 pseudophakic PDM. BGL as well as psychophysical measurements of visual function were measured preprandial and postprandial. Visual acuity (VA) was measured at distance (4 m) and near (40 cm) using logMAR VA charts, and contrast sensitivity (CS) was measured at 50 cm using a Mars chart. The data collected were captured and subsequently analyzed using SPSS version 25. RESULTS: Glycemic changes measured preprandial and postprandial observed a mean increase of 2.06±1.35 mmol/L (p=0.350) and 1.08±0.47 mmol/L (p=0.291) in pseudophakia PDM and pseudophakic PWDM, respectively. CS showed a mean increase of 0.01±0.10 (p=0.23) and 0.002±0.02 (p=0.19) log units in PDM and PWDM, respectively; however, the independent t-test showed this was insignificant between PDM and PWDM (p=0.27). A insignificant mean increase of 0.01±0.04 log units (p=0.25) and 0.001±0.01 (p=0.32) in distance VA of pseudophakic PDM and PWDM was found, respectively. A mean increase of 0.001±0.01 log units (p=0.32) and 0.01±0.03 (p=0.06) near logMAR VA of pseudophakic PDM and PWDM was found, respectively. CONCLUSION: Acute hyperglycemic changes do not result in overall significant changes in visual acuity and contrast sensitivity in pseudophakic PDM and PWDM for an increase in glycemia of 2 mmol/L. We recommend studies investigate if changes occur for glycemic increases exceeding 2 mmol/L.

The effect of gaming on accommodative and vergence facilities after exposure to virtual reality head-mounted display / Efecto del juego en la flexibilidad de acomodación y vergencia tras la exposición a un dispositivo de realidad virtual acoplado a la cabeza

BACKGROUND: To investigate the change between accommodative and vergence facilities before and after exposure to gaming in a virtual reality (VR) device amongst participants with normal binocular visual function. METHODS: 62 participants between the ages of 18-30 years with normal binocular visual function and inter-pupillary distances between 51 and 70 mm were selected for the study. Spectacle and contact lenses users were excluded. The experimental group (n = 42) was exposed to gaming using Samsung Gear VR(SM -R323) whilst the control group (n = 20) watched a television film projected on a two-dimensional screen at 1 m. Pre-test and post-test binocular amplitude-scaled facilities and vergence facilities were obtained for both groups after exposures of 25 min. RESULTS: Binocular accommodative facilities for the experimental group had a mean pre-test and post-test facility of 11.14 ± 3.67 cpm and 13.38 ± 3.63 cpm, respectively, after gaming using VR device. The vergence facilities for the experimental group had a mean pre-test and post-test facility of 11.41 ± 3.86 cpm and 15.28 ± 4.93 cpm, respectively, after gaming using a VR device. Binocular accommodative facilities for the control group had a mean pre-test and post-test facility of 11.70 ± 3.2 cpm and 11.95 ± 3.4 cpm, respectively. Vergence facilities for the control group had a mean pre-test and post-test facility of 11.55 ± 6.4 cpm and 11.70 ± 4.9 cpm, respectively. The mean change for binocular accommodative facilities was 2.24 ± 3.43 cpm and 0.25 ± 1.25 cpm for the experimental and control group, respectively. The mean change for vergence facilities was 3.81 ± 3.09 cpm and 0.15 ± 2.72 cpm for the experimental and control group, respectively. Binocular accommodative facilities and vergence facility showed a statistically significant mean increase greater than the control group after gaming using a VR device using an independent t-test (p < 0.05). CONCLUSION: The results showed that binocular accommodative facilities and vergence facilities increased after 25 min of VR gaming in emmetropic participants under 30 years of age with inter-pupillary distances between 51 mm and 70 mm

ANTECEDENTES: Investigar el cambio en la flexibilidad de acomodación y vergencia antes y después de la exposición al juego en un dispositivo de realidad virtual (RV) entre participantes con función visual binocular normal. MÉTODOS: Para el estudio se seleccionó a 62 participantes de edades comprendidas entre 18 y 30 años, con función visual binocular normal y distancias inter-pupilares comprendidas entre 51 y 70 mm. Se excluyó a los usuarios de gafas y lentillas. El grupo experimental (n = 42) se expuso al juego utilizando Samsung Gear VR (SM-R323), mientras el grupo control (n = 20) visionó una película de televisión proyectada en una pantalla de dos dimensiones a una distancia de 1 m. Se obtuvieron en ambos grupos los valores de flexibilidad de amplitud escalada binocular y de vergencia pre-test y post-test, tras una exposición de 25 minutos. RESULTADOS: Los valores medios de flexibilidad de acomodación binocular pre-test y post-test para el grupo experimental fueron de 11,14 ± 3,67 cpm y 13,38 ± 3,63 cpm, respectivamente, tras el juego con el dispositivo de RV. Los valores medios de flexibilidad de vergencia para el grupo experimental fueron de 11,41 ± 3,86 cpm y 15,28 ± 4,93 cpm, respectivamente, tras el juego con el dispositivo de RV. Los valores medios de flexibilidad de acomodación binocular pre-test y post-test para el grupo control fueron de 11,7 ± 3,2 cpm y 11,95 ± 3,4 cpm, respectivamente. Los valores medios de flexibilidad de vergencia pre-test y post-test para el grupo control fueron de 11,55 ± 6,4 cpm y 11,7 ± 4,9 cpm, respectivamente. Los valores del cambio medio para la flexibilidad de acomodación binocular fueron de 2,24 ± 3,43 cpm y 0,25 ± 1,25 cpm para los grupos experimental y control, respectivamente. Los valores del cambio medio para la flexibilidad de vergencia fueron de 3,81 ± 3,09 cpm y 0,15 ± 2,72 cpm para los grupos experimental y control, respectivamente. La flexibilidad binocular de acomodación y vergencia reflejó un incremento medio estadísticamente significativo superior con respecto al grupo control tras el juego con un dispositivo de RV, utilizando una prueba t independiente p < 0,05. CONCLUSIÓN: Los resultados reflejaron que la flexibilidad de acomodación binocular y la flexibilidad de vergencia se incrementaron tras 25 minutos de juego con RV en los participantes emetrópicos menores de 30 años, con distancias inter-pupilares comprendidas entre 51 y 70 mm

The effect of gaming on accommodative and vergence facilities after exposure to virtual reality head-mounted display.

BACKGROUND: To investigate the change between accommodative and vergence facilities before and after exposure to gaming in a virtual reality (VR) device amongst participants with normal binocular visual function. METHODS: 62 participants between the ages of 18-30 years with normal binocular visual function and inter-pupillary distances between 51 and 70 mm were selected for the study. Spectacle and contact lenses users were excluded. The experimental group (n = 42) was exposed to gaming using Samsung Gear VR(SM -R323) whilst the control group (n = 20) watched a television film projected on a two-dimensional screen at 1 m. Pre-test and post-test binocular amplitude-scaled facilities and vergence facilities were obtained for both groups after exposures of 25 min. RESULTS: Binocular accommodative facilities for the experimental group had a mean pre-test and post-test facility of 11.14 ± 3.67 cpm and 13.38 ± 3.63 cpm, respectively, after gaming using VR device. The vergence facilities for the experimental group had a mean pre-test and post-test facility of 11.41 ± 3.86 cpm and 15.28 ± 4.93 cpm, respectively, after gaming using a VR device. Binocular accommodative facilities for the control group had a mean pre-test and post-test facility of 11.70 ± 3.2 cpm and 11.95 ± 3.4 cpm, respectively. Vergence facilities for the control group had a mean pre-test and post-test facility of 11.55 ± 6.4 cpm and 11.70 ± 4.9 cpm, respectively. The mean change for binocular accommodative facilities was 2.24 ± 3.43 cpm and 0.25 ± 1.25 cpm for the experimental and control group, respectively. The mean change for vergence facilities was 3.81 ± 3.09 cpm and 0.15 ± 2.72 cpm for the experimental and control group, respectively. Binocular accommodative facilities and vergence facility showed a statistically significant mean increase greater than the control group after gaming using a VR device using an independent t-test (p < 0.05). CONCLUSION: The results showed that binocular accommodative facilities and vergence facilities increased after 25 min of VR gaming in emmetropic participants under 30 years of age with inter-pupillary distances between 51 mm and 70 mm.