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AIM: endoscopy identifies inflammatory activity, however, it is an unpleasant test and is not always accessible. The aim of the study was to compare the usefulness of quantitative fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD). METHODS: cross-sectional prospective observational study. The stool samples were collected within three days before starting the preparation for the colonoscopy. We used the Mayo index for ulcerative colitis (UC) and the simplified endoscopic index for Crohn's disease (CD). Mucosal healing (MH) was defined as the score 0 points in each of the endoscopic indices. RESULTS: eighty-four patients were included, 40 (47.6 %) with UC. In patients with IBD, FIT and FC showed a significant correlation with the presence of inflammatory activity/MH on endoscopy, with no statistically significant differences between the two receiver-operating characteristic (ROC) curves. Both tests improved their diagnostic performance when assessing patients with UC; the Spearman correlations between FIT and FC and endoscopic inflammatory activity were r = 0.6 (p = 0.0001) and r = 0.7 (p = 0.0001), respectively. In Crohn's disease, the diagnostic utility of both tests was lower. CONCLUSIONS: FIT is an alternative to monitor endoscopic activity among ulcerative colitis patients. In Crohn's disease, more studies are needed to determine the role of fecal biomarkers.
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Introducción. La tromboelastografía es la herramienta que permite medir in vitro las propiedades viscoelásticas de la sangre de una manera dinámica y global, integrando las diferentes fases de la coagulación y fibrinólisis. Existen en el mercado dos dispositivos semiautomatizados: el tromboelastograma y el tromboelastómetro rotacional. Material y métodos. Se ha realizado un estudio observacional descriptivo retrospectivo de las solicitudes de tromboelastometría en nuestro hospital desde la implementación del protocolo con la técnica centralizada desde el laboratorio. Se ha evaluado el número de solicitudes, los servicios peticionarios y el grado de cumplimentación de la petición al laboratorio. Así mismo, hemos realizado una encuesta de satisfacción dirigida al personal facultativo del Servicio de Anestesia y Reanimación. El periodo estudiado fue de julio del 2012 a enero del 2016. Resultados. Desde el establecimiento del protocolo hasta la actualidad se ha producido un incremento y una consolidación de la técnica de tromboelastometría en nuestro hospital. La mayor parte de las solicitudes proceden de los Servicios de Anestesia y Reanimación (36,5%) y Angiología y Cirugía Cardiovascular (30,1%). En cuanto a la encuesta de satisfacción, los resultados obtenidos muestran una aceptación positiva por parte de los facultativos tanto con el protocolo como con los tiempos de respuesta obtenidos. Conclusiones. Estableciendo un protocolo elaborado y consensuado entre el laboratorio y los servicios solicitantes, podemos garantizar el estricto cumplimiento del mismo y que los tiempos de respuesta difieran poco de los obtenidos cuando esta técnica se realiza en la cabecera del paciente, permitiendo así dar un servicio global a todo el hospital (AU)
Introduction. Thromboelastography is the tool that allows in vitro measurement of the viscoelastic properties of the blood in a dynamic and comprehensive way, integrating the different phases of coagulation and fibrinolysis. There are two semi-automated devices on the market: the thromboelastogram and the rotational thromboelastometry analyzer. Material and methods. We have conducted a descriptive observatory retrospective study of the thromboelastography requests in our hospital after the implementation of the protocol. It has been evaluated the number of petitions, the petitioners services and the degree of filling of the application laboratory. Likewise, we have performed a satisfaction survey aimed at the medical staff of the Anesthesia and Resuscitation Service. The studied period was from July 2012 until January 2016. Results. From the protocol introduction in our hospital has been produced an increase and a consolidation of the thromboelastography. Most of the requests came from the Anesthesia and Resuscitation Service (36.5%) and Angiology and Cardiovascular Surgery Service (30.1%). As for the satisfaction survey, the results show a positive acceptance by the medical staff both of the protocol as of the response times obtained. Conclusions. By establishing a protocol elaborated and agreed between the laboratory and the requesting departments, we can guarantee the strict compliance of the same and that the response times only differ a little from the obtained ones when this technique is realized as point of care testing, providing a global service to the whole hospital (AU)
