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Obesity (Silver Spring) ; 22(7): 1679-84, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24634403

RESUMO

OBJECTIVE: To compare the regional differences in subcutaneous adipose tissue hormone/cytokine production in abdominally obese women during weight loss. METHODS: Forty-two abdominally obese, older women underwent a 20-week weight loss intervention composed of hypocaloric diet with or without aerobic exercise (total energy expenditure: ∼2800 kcal/week). Subcutaneous (gluteal and abdominal) adipose tissue biopsies were conducted before and after the intervention. Adipose tissue gene expression and release of leptin, adiponectin, and interleukin 6 (IL-6) were determined. RESULTS: The intervention resulted in significant weight loss (-10.1 ± 0.7 kg, P < 0.001). At baseline, gene expression of adiponectin were higher (P < 0.01), and gene expression and release of IL-6 were lower (both P < 0.05) in abdominal than in gluteal adipose tissue. After intervention, leptin gene expression and release were lower in both gluteal and abdominal adipose tissue compared to baseline (P < 0.05-0.01). Abdominal, but not gluteal, adipose tissue adiponectin gene expression and release increased after intervention (both P < 0.05). CONCLUSION: A 20-week weight loss program decreased leptin production in both gluteal and abdominal adipose tissue, but only increased adiponectin production from abdominal adipose tissue in obese women. This depot-specific effect may be of importance for the treatment of health complications associated with abdominal adiposity.


Assuntos
Adiponectina/metabolismo , Tecido Adiposo/fisiopatologia , Citocinas/metabolismo , Dieta Redutora , Exercício Físico , Interleucina-6/metabolismo , Leptina/metabolismo , Obesidade Abdominal/fisiopatologia , Redução de Peso/fisiologia , Adulto , Idoso , Ingestão de Energia/fisiologia , Feminino , Humanos , Pessoa de Meia-Idade
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