Ivermectin prescription fill rates among U.S. Military members during the coronavirus disease 2019 (COVID-19) pandemic.

This report describes ivermectin prescription fill rates among U.S. active component service members (ACSM) over time during the early phases of the COVID-19 pandemic. Information about the unsubstantiated benefits of ivermectin for coronavirus 2019 (COVID-19) prevention and treatment was widely available online early in the COVID-19 pandemic. Ivermectin prescription fill rates increased among ACSM during periods of Alpha and Delta coronavirus variant predominance, but not during the predominance of the Omicron variant. At the peak of the fill rate curve, in August 2021, rates were higher among men compared to women, older compared to younger age groups, senior officers compared to junior officers, senior enlisted compared to junior enlisted service members, and those with a bachelor's or advanced degree compared to those without a bachelor's degree. Ivermectin prescriptions were more likely to have been filled at a retail pharmacy than at a military hospital or clinic. During the COVID-19 pandemic fill rates for ivermectin prescriptions among ACSM increased, including those without a qualifying diagnosis. Rates peaked in August 2021 but subsequently declined. The decrease in ivermectin fill rates was coincident with vigorous efforts to correct previous misinformation and implement pre-authorization requirements for prescriptions. Research on the impact of unproven online claims about clinical and public health interventions has potential to curtail future unnecessary and potentially harmful treatments.

Incidence of Colorectal Cancer Among Active Component Service Members, 2010-2022.

Colorectal cancer, which is more predominant among men than women, has been shown to be associated with environmental and occupational risk factors experienced by military members. The Defense Medical Surveillance System (DMSS) was used to determine the crude and age-adjusted incidence rates of colorectal cancer among active component service members from all military services from January 1, 2010 to December 31, 2022. Results from this analysis show higher crude incidence rates of colorectal cancer among those who are older and male. The overall age-adjusted incidence rate throughout the surveillance period ranged from 3.56 (95% CI: 2.54-4.58) to 7.92 (95% CI: 5.98-9.86) cases per 100,000 person-years. Age-adjusted colorectal cancer rates were similar for males and females (4.46 and 4.33 cases per 100,000 person-years, respectively) and rates were relatively similar by service as well as race and ethnicity. This finding could be attributed to the small number of cases in this study due to better screening practices in the Military Health System (MHS). Although non-Hispanic Black service members have historically had the highest incidence of colorectal cancer within the U.S. military, this study observed similar rates of colorectal cancer for all races and ethnicities after adjusting for age. Incident rates of colorectal cancer within the U.S. military increase monotonically with age, with service members over the age of 45 with the highest incidence, re-enforcing the need to promote wellness screening among military populations. The importance of the DHA guideline changes that decreased colorectal screenings to age 45 years is significant.

Trends in the Incidence of Eating Disorders Among Active Component Service Members, 2017 to 2021.

From 2017 through 2021, a total of 2,454 active component U.S. military service members received incident diagnoses for 1 of the following eating disorders: anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), or "other/unspecified eating disorder" (OUED). The incidence rate of any eating disorder was 3.6 cases per 10,000 person-years (p-yrs). The case defining diagnoses OUED, BN, and BED accounted for nearly 89% of total incident cases. The incidence rate of any eating disorder among women was more than 8 times the rate among men. Overall rates were highest among service members under 30 years of age. Crude annual incidence rates of total eating disorders increased in 2021, following the COVID-19 pandemic. Increased prevalence of major life stressors and mental health conditions were reported on Periodic Health Assessment (PHA) forms completed in the 1-year period after an eating disorder diagnosis. These data suggest the need for increased attention to eating disorder prevention. Additionally, treatment programs could be warranted as continued effects of the COVID-19 pandemic are elucidated within the military population.