RESUMO
In this issue of JCP, Zhou and colleagues review and integrate placebo-controlled efficacy trials of medications for treatment-resistant depression (TRD) to compare efficacy in a meta-analysis. They conclude that, among 11 augmentation options for TRD, aripiprazole and quetiapine have the most robust evidence for efficacy, with the caveats that these treatments carry substantial risks of adverse events and no long-term data are available. In the absence of direct comparisons, this exercise highlights the formidable challenges that clinicians face when making decisions.
Assuntos
Antidepressivos/uso terapêutico , Transtorno Depressivo Maior/tratamento farmacológico , Transtorno Depressivo Resistente a Tratamento/tratamento farmacológico , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Feminino , Humanos , MasculinoRESUMO
Callithrix aurita, an endangered marmoset endemic to eastern Brazil, was observed from June to October 1982. Preliminary observations suggest that behavioral and morphological differences exist which distinguish C. aurita from the common marmoset, C. jacchus. New data are provided on the geographic distribution of C. aurita, extending it northward within the known ranges of C. penicillata in the states of Sao Paulo and Minas Gerais and C. flaviceps in eastern Minas Gerais.
