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Eur J Neurol ; 17(4): 582-8, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20050889

RESUMO

BACKGROUND: Churg-Strauss syndrome (CSS) is a rare systemic vasculitis. Case series with a focus on neurologic involvement are not common. With this study, we intended to evaluate the frequency and types of neurologic manifestations and complications at time of diagnosis and during follow-up of patients with CSS. METHODS: In this monocentric study, consecutive patients of our hospital with first diagnosis of CSS based on the criteria of the American College of Rheumatology were included between 2001 and 2007. Each patient underwent a periodic follow-up with clinical and electrophysiologic examination. Data were obtained prospectively. RESULTS: Fourteen patients were included. All patients had a hypereosinophilia and a history of asthma. Twelve of 14 patients had a neurologic involvement, mainly as an acute or subacute multiplex mononeuropathy (eight patients) or an axonal polyneuropathy (three patients). Three patients suffered from a neuropathy of cranial nerves, and two patients had a cerebral infarct. Mean follow-up period was 31 months. With immunosuppressive therapy, 13 patients had no additional neurologic complications, one patient suffered from a cerebral infarct. Initial neurologic symptoms as a result of peripheral neuropathy improved, but sequelae of axonal damage were persistently detectable. CONCLUSIONS: Even at time of diagnosis of a CSS, neurologic manifestations are common, especially as a multiplex mononeuropathy. With a consequent immunosuppressive therapy, new neurologic complications can be avoided for the most part.


Assuntos
Infarto Encefálico/complicações , Síndrome de Churg-Strauss/complicações , Doenças dos Nervos Cranianos/complicações , Doenças do Sistema Nervoso Periférico/complicações , Doença Aguda , Adulto , Idoso , Infarto Encefálico/tratamento farmacológico , Síndrome de Churg-Strauss/tratamento farmacológico , Doenças dos Nervos Cranianos/tratamento farmacológico , Feminino , Seguimentos , Humanos , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Mononeuropatias/complicações , Mononeuropatias/tratamento farmacológico , Doenças do Sistema Nervoso Periférico/tratamento farmacológico , Polineuropatias/complicações , Polineuropatias/tratamento farmacológico , Estudos Prospectivos
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