RESUMO
The possibilities are shown of using officinal glycerin as a polyatomic alcohol in the treatment of alcoholism, in particular, alcohol abstinent syndrome. The theoretical basis of using glycerin is the possibility of replacing ethanol by a substance with a similar chemical structure not possessing euphoric and narcotic effect. Clinical results showed the rationality of using glycerin as an antialcohol substance.
Assuntos
Dissuasores de Álcool , Alcoolismo/tratamento farmacológico , Glicerol/uso terapêutico , Administração Oral , Adulto , Avaliação de Medicamentos , Etanol/efeitos adversos , Humanos , Pessoa de Meia-Idade , Soluções , Síndrome de Abstinência a Substâncias/tratamento farmacológico , Fatores de TempoAssuntos
Alcoolismo/tratamento farmacológico , alfa-Globulinas/uso terapêutico , beta-Globulinas/uso terapêutico , Albumina Sérica/uso terapêutico , Adulto , Combinação de Medicamentos , Avaliação de Medicamentos , Etanol/efeitos adversos , Humanos , Pessoa de Meia-Idade , Síndrome de Abstinência a Substâncias/tratamento farmacológicoRESUMO
After administration of isadrine excretion of noradrenaline was increased in schizophrenic patients with symptoms of depression or anxiety. This phenomenon was not observed in healthy persons and in patients with circular depression. Data on liberation of noradrenaline by other amines in schizophrenia and displacement of noradrenaline in schizophrenia by isadrine, which does not accumulate in normal storage sites, suggest that storage of noradrenaline is impaired in schizophrenia.
Assuntos
Isoproterenol , Norepinefrina/metabolismo , Esquizofrenia/metabolismo , Ansiedade , Transtorno Bipolar/metabolismo , Depressão/metabolismo , Feminino , Humanos , Masculino , Estresse Psicológico , SíndromeRESUMO
The paper deals with a study of 83 patients with different forms of schizophrenia and 15 normals where the methylating activity in converting nicotinamid into methylnicotinamid was determined and the activity of catechol-methyltransferase. In schizophrenic patients there is an increase of the methylating activity which significantly correlated with hallucinatory symptoms in the clinical picture. In patients with cataono-paranoid, paranoid syndromes and simple forms of schizophrenia the methylating activity is seen significantly less frequently. The disappearance of alleviation of hallucinations, due to neuroleptical drugs is accompanied by normalization of the methylating activity. Any significant differences in the excretion of isdarin as an index of cathechol-o-methyltransferase activity in normals and schizophrenic patients was not established.