RESUMO
O uso do ácido hialurônico (AH) injetável no preenchimento de rugas e volumização facial está consagrado na prática dermatológica. O manejo de suas complicações, embora raras, deve ser do conhecimento do dermatologista. No uso dos preenchedores de aplicação mais profunda, a formação de nódulos pode ocorrer, e a conduta é similar à utilizada para preenchedores mais superficiais e menos viscosos. O uso da cânula mais fina possivelmente reduz esse risco, sobretudo em áreas de derme mais fina.
The use of injectable hyaluronic acid (HA) in wrinkle filling and facial volumization is well established in the dermatological practice. While complications are rare, techniques for their management should be known by the dermatologist. Nodules may occur with the use of deeper application fillers, and the treatment is similar to that used for the more superficial and less viscous fillers. The use of a thinner cannula may reduce this risk, especially in areas where the dermis is thinner.
RESUMO
The aim of the present study was to investigate the immune response to native outer membrane vesicles (NOMVs) of Neisseria lactamica with and without Bordetella pertussis (BP) as adjuvant in intranasal (i.n./i.m) immunization. N. lactamica NOMVs delivered intranasally (i.n) to BALB/c mice in a final volume of 5microl that was gradually introduced with a micropipette, Animals received 1, 2, 3, or 4 doses of antigens at 3, 7, 9 and 12 days after birth. On the 35th day, the animals were immunized intramuscularly (i.m.) with (NOMV) of N. lactamica. The prime-booster strategy using NOMV of N. lactamica with BP as adjuvant in the primer (i.n.) and booster (i.m.) is an effective immunization protocol for inducing humoral immune responses producing IgG antibodies of intermediate to high avidity.