16-channel SiPM high-frequency readout with time-over-threshold discrimination for ultrafast time-of-flight applications.

BACKGROUND: Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can further push the limits in light detection and ranging (LiDAR), time-of-flight positron-emission tomography (TOF-PET), time-of-flight computed tomography (TOF-CT) or high-energy physics (HEP). However, upscaling these electronics to a system-applicable, multi-channel readout, has remained a challenging task, posed by the use of discrete components and a high power consumption. To this day, there are no means to exploit the high TOF resolution of these electronics on system scale or to measure the actual timing performance limits of a full detector block. METHODS: In this work, we present a 16-channel HF readout board, including leading-edge discrimination and a linearized time-over-threshold (TOT) method, which is fully compatible with a high-precision time-to-digital converters (TDCs), such as the picoTDC developed at CERN. The discrete implementation allows ideal adaptation of this readout to a broad range of detection tasks. As a first step, the functionality of the circuit has been tested using the TOFPET2 ASIC as back-end electronics to emulate the TDC, also in view of its properties as a highly scalable data acquisition solution. RESULTS: The produced board is able to mitigate influences of baseline shifts in the TOFPET2 front end, which has been shown in experiments with a pulsed laser, increasing the achievable intrinsic coincidence timing resolution (CTR) of the TOFPET2 readout electronics from 70 ps (FWHM) to 62 ps (FWHM). Single-channel coincidence experiments including a [Formula: see text]-source, 2[Formula: see text]2[Formula: see text]3 mm[Formula: see text] LYSO:Ce,Ca crystals and Broadcom NUV-MT SiPMs resulted in a CTR of 118 ps (FWHM). For a 4[Formula: see text]4 matrix of 3.88[Formula: see text]3.88[Formula: see text]19 mm[Formula: see text] LYSO:Ce,Ca crystals one-to-one coupled to a 4[Formula: see text]4 array of Broadcom NUV-MT SiPMs, an average CTR of 223 ps (FWHM) was obtained. CONCLUSION: The implemented 16-channel HF electronics are fully functionall and have a negligible influence on the timing performance of the back-end electronics used, here the TOFPET2 ASIC. The ongoing integration of the picoTDC with the 16-channel HF board is expected to further set the path toward sub-100 ps TOF-PET and sub-30ps TOF resolution for single-photon detection.

A time-based double-sided readout concept of 100 mm LYSO:Ce,Ca fibres for future axial TOF-PET.

BACKGROUND: Positron emission tomography (PET) requires a high signal-to-noise ratio (SNR) to improve image quality, with time-of-flight (TOF) being an effective way to boost the SNR. However, the scanner sensitivity and resolution must be maintained. The use of axially aligned 100-mm LYSO:Ce,Ca scintillation crystals with double-sided readout has the potential of ground-breaking TOF and sensitivity, while reducing parallax errors through depth-of-interaction (DOI) estimation, and also allowing a reduction in the number of readout channels required, resulting in cost benefits. Due to orientation, these fibres may also facilitate the integration of TOF-PET with magnetic resonance imaging (MRI) in hybrid imaging systems. The challenge of achieving a good spatial resolution with such long axial fibres is directly related to the achievable TOF resolution. In this study, the timing performance and DOI resolution of emerging high-performance materials were investigated to assess the merits of this approach in organ-dedicated or total-body/large-scale PET imaging systems. METHODS: LYSO:Ce,Ca scintillation fibres of 20 mm and 100 mm length were tested in various operating and readout configurations to determine the best achievable coincidence time resolution (CTR) and DOI resolution. The tests were performed using state-of-the-art high-frequency (HF) readout and commercially available silicon photomultipliers (SiPMs) from Broadcom Inc. RESULTS: For the 100-mm fibre, an average CTR performance of [Formula: see text] ps FWHM and an average depth-of-interaction resolution within the fibre of [Formula: see text] mm FWHM could be obtained. The 20-mm fibre showed a sub-100 ps CTR of [Formula: see text] ps FWHM and a fibre resolution of [Formula: see text] mm FWHM in the double-sided readout configuration. CONCLUSION: With modern SiPMs and crystals, a double-sided readout of long fibres can achieve excellent timing resolution and field-advancing TOF resolution, outperforming commercial PET systems. With 100-mm fibres, an electronic channel reduction of about a factor 2.5 is inherent, with larger reduction factors conceivable, which can lead to lower production costs. The spatial resolution was shown to be limited in the axial direction with 12 mm, but is defined to 3 mm in all other directions. Recent SiPM and scintillator developments are expected to improve on the time and spatial resolution to be investigated in future prototypes.

Timing advances of commercial divalent-ion co-doped LYSO:Ce and SiPMs in sub-100 ps time-of-flight positron emission tomography.

Objective.Together with novel photodetector technologies and emerging electronic front-end designs, scintillator material research is one of the key aspects to obtain ultra-fast timing in time-of-flight positron emission tomography (TOF-PET). In the late 1990s, Cerium-doped lutetium-yttrium oxyorthosilicate (LYSO:Ce) has been established as the state-of-the-art PET scintillator due to its fast decay time, high light yield and high stopping power. It has been shown that co-doping with divalent ions, such as Ca2+and Mg2+, is beneficial for its scintillation characteristics and timing performance. Therefore, this work aims to identify a fast scintillation material to combine it with novel photosensor technologies to push the state of the art in TOF-PET.Approach.This study evaluates commercially available LYSO:Ce,Ca and LYSO:Ce,Mg samples manufactured by Taiwan Applied Crystal Co., LTD regarding their rise and decay times as well as their coincidence time resolution (CTR) with both ultra-fast high-frequency (HF) readout and commercially available readout electronics, i.e. the TOFPET2 ASIC.Main results.The co-doped samples exhibit state-of-the-art rise times of on average 60 ps and effective decay times of on average 35 ns. Using the latest technological improvements made on NUV-MT SiPMs by Fondazione Bruno Kessler and Broadcom Inc., a 3 × 3 × 19 mm3LYSO:Ce,Ca crystal achieves a CTR of 95 ps (FWHM) with ultra-fast HF readout and 157 ps (FWHM) with the system-applicable TOFPET2 ASIC. Evaluating the timing limits of the scintillation material, we even show a CTR of 56 ps (FWHM) for small 2 × 2 × 3 mm3pixels. A complete overview of the timing performance obtained with different coatings (Teflon, BaSO4) and different crystal sizes coupled to standard Broadcom AFBR-S4N33C013 SiPMs will be presented and discussed.Significance.This work thoroughly evaluates commercially available co-doped LYSO:Ce crystals and, in combination with novel NUV-MT SiPMs, shows a TOF performance that significantly exceeds the current state of the art.

Hybrid total-body pet scanners-current status and future perspectives.

Purpose Since the 1990s, PET has been successfully combined with MR or CT systems. In the past years, especially PET systems have seen a trend towards an enlarged axial field of view (FOV), up to a factor of ten. Methods Conducting a thorough literature research, we summarize the status quo of contemporary total-body (TB) PET/CT scanners and give an outlook on possible future developments. Results Currently, three human TB PET/CT systems have been developed: The PennPET Explorer, the uExplorer, and the Biograph Vision Quadra realize aFOVs between 1 and 2 m and show a tremendous increase in system sensitivity related to their longer gantries. Conclusion The increased system sensitivity paves the way for short-term, low-dose, and dynamic TB imaging as well as new examination methods in almost all areas of imaging.

Evaluation of the PETsys TOFPET2 ASIC in multi-channel coincidence experiments.

BACKGROUND: Aiming to measure the difference in arrival times of two coincident γ-photons with an accuracy in the order of 200ps, time-of-flight positron emission tomography systems commonly employ silicon photomultipliers (SiPMs) and high-resolution digitization electronics, application specific integrated circuits (ASICs). This work evaluates the performance of the TOFPET2 ASIC, released by PETsys Electronics S.A. in 2017, dependent on its configuration parameters in multi-channel coincidence measurements. METHODS: SiPM arrays fabricated by different vendors (KETEK, SensL, Hamamatsu, Broadcom) were tested in combination with the ASIC. Scintillator arrays featuring different reflector designs and different configurations of the TOFPET2 ASIC software parameters were evaluated. The benchtop setup used is provided with the TOFPET2 ASIC evaluation kit by PETsys Electronics S.A. RESULTS: Compared to existing studies featuring the TOFPET2 ASIC, multi-channel performance results dependent on a larger set of ASIC configuration parameters were obtained that have not been reported to this extend so far. The ASIC shows promising CRTs down to 219.9 ps in combination with two Hamamatsu S14161-3050-HS-08 SiPM arrays (128 channels read out, energy resolution 13.08%) and 216.1 ps in combination with two Broadcom AFBR-S4N44P643S SiPM arrays (32 channels read out, energy resolution 9.46%). The length of the trigger delay of the dark count suppression scheme has an impact on the ASIC performance and can be configured to further improve the coincidence resolution time. The integrator gain configuration has been investigated and allows an absolute improvement of the energy resolution by up to 1% at the cost of the linearity of the energy spectrum. CONCLUSION: Measuring up to the time-of-flight performance of state-of-the-art positron emission tomography (ToF-PET) systems while providing a uniform and stable readout for multiple channels at the same time, the TOFPET2 ASIC is treated as promising candidate for the integration in future ToF-PET systems.