RESUMO
A new compound, 3-O-alpha-L-arabinopyranosyl-4-hydroxybenzoic acid (13), in addition to 16 newly reported compounds: alpha-amyrin acetate (1), beta-amyrone (2), 3beta-acetoxy-20-taraxasten-22-one (3), alpha-amyrin (4), ceryl alcohol (5), stigmasterol (6), beta-sitosterol (7), 2alpha,3alpha-dihydroxy-lup-20(29)-en-28-oate (8), ursolic acid (9), beta-sitosterol-3-O-glucosoide (10), protocatechuic acid (11), betulinic acid (12), quercetin (14), quercetin-3-O-beta-D-glucoside (15), kampferol-3-O-beta-neohesperidoside (16) and rutin (17) were isolated from the stem bark and leaves of Ficus pandurata (Hance) cultivated in Egypt. Identification of these compounds has been established by physical, chemical and spectral data (UV, IR, MS, (1)H- and (13)C-NMR), as well as comparison with authentic samples.
Assuntos
Ficus/química , Casca de Planta/química , Folhas de Planta/química , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Ácido Oleanólico/análogos & derivados , Ácido Oleanólico/química , Triterpenos Pentacíclicos , Sitosteroides/química , Espectrofotometria Infravermelho , Espectrofotometria Ultravioleta , Estigmasterol/química , Triterpenos/química , Ácido Betulínico , Ácido UrsólicoRESUMO
A new pentacyclic oleanene triterpene, 2beta, 3beta, 16alpha, 28-tetrahydroxy-olean-12-ene-23-oic acid (1), as well as the known pentacyclic triterpene medicagenic acid (2), have been isolated by different chromatographic techniques from the acid hydrolysate of the saponin fraction of Gladiolus segetum. The identification of these compounds was established by different methods of physical, chemical and spectral evidence.
Assuntos
Iridaceae/química , Ácido Oleanólico/isolamento & purificação , Saponinas/isolamento & purificação , Espectroscopia de Ressonância Magnética , Estrutura MolecularRESUMO
The study examines the anti-ulcer activity of Cu(I)-(nicotinic acid)2Cl [CuCl(HNA)2]. A dose of 8 mg (23 mumol) of complex/kg body mass was suspended in 0.25% Tween-80 in saline solution and administered intragastrically to male Wistar albino rats which had developed gastric ulcers as a result of pyloric ligation (Shay-rat model). Another group of animals received 5 mg (25 mumol)/kg body mass of the copper-glycinate complex Cu(II)(glycinate)2 [Cu(II)(Gly)2]. Both protected as shown by reduction in the ulcer index, inhibition of gastric perforation and death. Significant increases in gastric juice volume and superoxide dismutase (SOD) activity in the gastric mucosa and blood plasma were found with both copper complexes, while the gastric juice prostaglandin E2 (PGE2) content was significantly decreased in the Cu(II)(Gly)2-treated group, it was significantly increased in the gastric mucosa of the CuCl(HNA)2-treated group. The copper complex-treated animals, especially those which received Cu(II)(Gly)2 had a marked fall in thromboxane A2 (TXA2) levels. These results suggest that intragastric administration of either CuCl(HNA)2 or Cu(II)(Gly)2 produced anti-ulcerogenic activity, with different modes of action.
