Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors.

Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-ß inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.

Side chain-directed assembly of triangular molecular panels into a tetrahedron vs. open cone.

Despite their structural similarity, triangular tetradentate ligands 2b and 2c experience different assembly pathways on complexation with (en)Pd(NO3)2 to give M8L4 tetrahedral (3) and open cone (4) structures, respectively, due to steric restriction by side chains at the corner or on the edge of the ligands.