Assuntos
Aflatoxinas , Carcinoma de Células Escamosas/etiologia , Metoxaleno/efeitos adversos , Transtornos de Fotossensibilidade/etiologia , Neoplasias Cutâneas/etiologia , Aflatoxina B1 , Animais , Carcinoma de Células Escamosas/induzido quimicamente , Ceratose/etiologia , Camundongos , Transtornos de Fotossensibilidade/induzido quimicamente , Neoplasias Cutâneas/induzido quimicamente , Raios Ultravioleta/efeitos adversosRESUMO
The carcinogenicity of 8-methoxypsoralen (8-MOP) and aflatoxin B1 (AFB1) with longwave ultraviolet light (UVA) to hairless mouse skin was investigated. Skin tumors were induced efficiently by 8-MOP + UVA, and the time to 50% tumor incidence was about 24 weeks. Histopathologically, some tumors were squamous cell carcinomas. AFB1 did not show any phototoxic and photocarcinogenic effects on mouse skin in this study. Although the structure and the photoreactivity of AFB1 to DNA were similar to those of 8-MOP, the photocarcinogenic response of these compounds to mouse skin was quite different.
Assuntos
Aflatoxinas/farmacologia , Carcinógenos/farmacologia , Carcinoma de Células Escamosas/etiologia , Metoxaleno/farmacologia , Neoplasias Cutâneas/etiologia , Raios Ultravioleta , Aflatoxina B1 , Animais , Camundongos , Neoplasias Experimentais/etiologia , Fotoquímica , Fatores de TempoRESUMO
The urinary levels of pseudouridine in 16 healthy subjects and 16 patients with psoriasis were evaluated with boronate affinity gel chromatography and reversed phase high-performance liquid chromatography. The mean values of pseudouridine (nmol)/creatinine (mumol) for controls and patients were 21.34 and 18.48 for males, and 21.67 and 23.90 for females, respectively. No significant difference was observed between controls and patients.