1.
J Neuroimmunol
; 208(1-2): 115-8, 2009 Mar 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19201038
RESUMO
Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p=0.027; p=0.032). The G allele may be one of the factors responsible for progression in PPMS.
Assuntos
Esclerose Múltipla Crônica Progressiva/genética , Polimorfismo Genético/genética , Fator de Necrose Tumoral alfa/genética , Adenina , Adulto , Feminino , Frequência do Gene/genética , Predisposição Genética para Doença , Guanina , Humanos , Hungria , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla Crônica Progressiva/epidemiologia
2.
Swiss Med Wkly
; 137(7-8): 130, 2007 Feb 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17370152