RESUMO
Treatment of arterial traumatic intimal lesions is controversial due to its unknown natural history. Current therapeutical options include arterial reconstruction and clinical observation. The idea of using stents to correct intimal flaps is based on their use to correct dissections, flaps, and arterial irregularities after angioplasty. We report the successful treatment of a traumatic intimal flap of the superficial femoral artery, caused by gunshot trauma, with a Palmaz stent in the acute period. One year after the operation, a duplex scan revealed normal flow in the artery and complete exclusion of the intimal flap; distal pulses were palpable, and the patient was completely asymptomatic.
Assuntos
Artéria Femoral/lesões , Stents , Túnica Íntima/lesões , Ferimentos por Arma de Fogo/terapia , Adulto , Humanos , MasculinoRESUMO
Sequential Intermittent Pneumatic Compression (SIPC) is an accepted method for treatment of peripheral lymphedema. This prospective study evaluated the effect in 11 patients of a single session of SIPC on both lymphedema volume of the leg and isotope lymphography (99Tc dextran) before SIPC (control) and 48 hours later after a 3 hour session of SIPC. Qualitative analysis of the 2 lymphoscintigrams (LS) was done by image interpretation by 3 physicians on a blind study protocol. The LS protocol attributed an index score based on the following variables: appearance, density and number of lymphatics, dermal backflow and collateral lymphatics in leg and thigh, visualization and intensity of popliteal and inguinal lymph nodes. Volume of the leg edema was evaluated by measuring limb circumference before and after SIPC at 6 designated sites. Whereas there was a significant reduction of circumference in the leg after SIPC (p<0.05), there was no significant difference in the index scores of the LS before and after treatment. This acute or single session SIPC suggests that compression increased transport of lymph fluid (i.e., water) without comparable transport of macromolecules (i.e., protein). Alternatively, SIPC reduced lymphedema by decreasing blood capillary filtration (lymph formation) rather than by accelerating lymph return thereby restoring the balance in lymph kinetics responsible for edema in the first place.
Assuntos
Perna (Membro)/irrigação sanguínea , Linfedema/diagnóstico por imagem , Linfedema/fisiopatologia , Adulto , Idoso , Circulação Colateral/fisiologia , Feminino , Humanos , Cinética , Linfedema/terapia , Linfografia , Masculino , Pessoa de Meia-Idade , Pressão , Estudos Prospectivos , Tecnécio , Fatores de TempoRESUMO
Simultaneous repair of abdominal aortic aneurysm and treatment of cholelithiasis by the transperitoneal approach is controversial because of the risk of prosthesis infection. We report two patients who underwent a successful combined procedure using a retroperitoneal approach for the aortic aneurysm repair and a laparoscopic approach to the cholecystectomy. This combined approach reduces the risk of infection of the aortic prosthesis and is associated with a rapid return of normal peristalsis.
Assuntos
Aneurisma da Aorta Abdominal/cirurgia , Colecistectomia Laparoscópica , Colelitíase/cirurgia , Idoso , Idoso de 80 Anos ou mais , Aneurisma da Aorta Abdominal/complicações , Implante de Prótese Vascular , Colelitíase/complicações , Humanos , Masculino , Procedimentos Cirúrgicos Vasculares/métodosRESUMO
CONTEXT: Many patients with intermittent claudication continue to be forwarded to the vascular surgeon for initial evaluation after arteriography has already been accomplished. OBJECTIVE: The main objective of this work was to analyze the usefulness and the need for this procedure. TYPE OF STUDY: Retrospective study. SETTING: The patients were divided into two groups: Group 1, with the arteriography already performed and Group 2 without the initial arteriography. PARTICIPANTS: One hundred patients with intermittent claudication were retrospectively studied. Other specialists had forwarded them for the first evaluation of intermittent claudication, without any previous treatment. MAIN MEASUREMENTS: All patients were treated clinically for at least a 6-month period. The total number of arteriographies performed in the two groups was compared and the need and usefulness of the initial arteriography (of Group 1) was also analyzed. RESULTS: The evolution was similar for both groups. The total number of arteriographies was significantly higher in Group 1 (Group 1 with 53 arteriographies vs. Group 2 with 7 arteriographies). For this group, it was found that arteriography was only useful in five cases (10%), because the surgeries were based on their findings. However, even in those cases, no need for arteriography was observed, as the procedure could have been performed at the time of surgical indication. CONCLUSION: There are no indications for arteriography in the early evaluation of patients with intermittent claudication, because it does not modify the initial therapy, independent of its result. In cases where surgical treatment is indicated, this procedure should only be performed prior to surgery.
Assuntos
Claudicação Intermitente/diagnóstico por imagem , Angiografia/economia , Custos e Análise de Custo , Feminino , Seguimentos , Humanos , Claudicação Intermitente/economia , Claudicação Intermitente/cirurgia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estudos RetrospectivosRESUMO
No período de novembro de 1998 a dezembro de 1999 foram acompanhados 100 pacientes em atendimento domiciliar. Todos os pacientes foram incluídos no programa por apresentarem patologias crônicas que necessitam de cuidados hospitalares em seu domicílio. Foram avaliados aspectos como sexo, diagnóstico, tempo de acompanhamento, mortalidade e reinternaçöes. Após avaliaçäo dos dados concluímos que o atendimento domiciliar é uma modalidade de tratamento que auxilia no controle dos doentes com patologias crônicas, diminuindo o número e tempo de internaçöes hospitalares.
Assuntos
Humanos , Masculino , Feminino , Doença Crônica/reabilitação , Serviços de Assistência Domiciliar , Tratamento DomiciliarRESUMO
The purpose of this study was to determine whether the ankle-brachial index (ABI) could be used to predict the prognosis for a patient with intermittent claudication (IC). We studied 611 patients prospectively during 28 months of follow-up. We analyzed the predictive power of using various levels of ABI - 0.30 to 0.70 at 0.05 increments - in terms of the measure's specificity (association with a favorable outcome after exercise rehabilitation therapy) and sensitivity (association with a poor outcome after exercise rehabilitation therapy). We found that using an ABI of 0.30 as a cut-off value produced the lowest margin of error overall, but the predictive power was still low with respect to identifying the patients with a poor prognosis after non-aggressive therapeutic treatment. Further study is needed to perhaps identify a second factor that could increase the sensitivity of the test.
Assuntos
Tornozelo/irrigação sanguínea , Artéria Braquial/fisiopatologia , Claudicação Intermitente/fisiopatologia , Hemodinâmica , Humanos , Prognóstico , Estudos Prospectivos , Fluxo Sanguíneo Regional , Sensibilidade e EspecificidadeRESUMO
The time-course changes of the responsiveness of glycogen breakdown to alpha- and ss-adrenergic agonists during insulin-induced hypoglycemia (IIH) were investigated. Blood glucose levels were decreased prior to the alteration in the hepatic responsiveness to adrenergic agonists. The activation of hepatic glucose production and glycogenolysis by phenylephrine (2 microM) and isoproterenol (20 microM) was decreased in IIH. The changes in the responsiveness of glycogen catabolism were first observed for isoproterenol and later for phenylephrine. Hepatic ss-adrenergic receptors showed a higher degree of adrenergic desensitization than did alpha-receptors. Liver glycogen synthase activity, glycogen content and the catabolic effect of dibutyryl cyclic AMP (the ss-receptor second messenger) were not affected by IIH.
Assuntos
Agonistas alfa-Adrenérgicos/farmacologia , Agonistas Adrenérgicos beta/farmacologia , Bucladesina/farmacologia , Hipoglicemia/metabolismo , Glicogênio Hepático/metabolismo , Fígado/efeitos dos fármacos , Animais , Glucose/biossíntese , Glicólise/efeitos dos fármacos , Hipoglicemia/induzido quimicamente , Injeções Intraperitoneais , Insulina/administração & dosagem , Isoproterenol/farmacologia , Masculino , Fenilefrina/farmacologia , Ácido Pirúvico/metabolismo , Ratos , Ratos Wistar , Fatores de TempoRESUMO
The time-course changes of the responsiveness of glycogen breakdown to a- and Beta-adrenergic agonists during insulin-induced hypoglycemia (IIH) were investigated. Blood glucose levels were decreased prior to the alteration in the hepatic responsiveness to adrenergic agonists. The activation of hepatic glucose production and glycogenolysis by phenylephrine (2 µM) and isoproterenol (20 µM) was decreased in IIH. The changes in the responsiveness of glycogen catabolism were first observed for isoproterenol and later for phenylephrine. Hepatic ß-adrenergic receptors showed a higher degree of adrenergic desensitization than did a-receptors. Liver glycogen synthase activity, glycogen content and the catabolic effect of dibutyryl cyclic AMP (the Beta-receptor second messenger) were not affected by IIH.
Assuntos
Animais , Masculino , Ratos , Agonistas Adrenérgicos/farmacologia , Bucladesina/farmacologia , Hipoglicemia/metabolismo , Glicogênio Hepático/metabolismo , Fígado/efeitos dos fármacos , Agonistas alfa-Adrenérgicos/farmacologia , Glucose/biossíntese , Glicólise/efeitos dos fármacos , Hipoglicemia/induzido quimicamente , Injeções Intraperitoneais , Insulina/administração & dosagem , Isoproterenol/farmacologia , Fenilefrina/farmacologia , Ácido Pirúvico/metabolismo , Ratos Wistar , Fatores de TempoRESUMO
Young rats, with more body water, had lower blood alcohol concentrations than did older ones at several times after various doses. The young also recovered sooner from intoxication. The age difference in recovery increased with increasing dose.