RESUMO
Malignant gliomas of optic nerve and chiasm are rare, rapidly fatal neoplasms of adulthood. This report documents the occurrence of a malignant astrocytoma of the optic nerve in an 11-year-old boy who 9 years previously had a cerebellar medulloblastoma treated with surgery and irradiation. This malignant optic nerve glioma followed the same aggressive clinical course as that seen in adults, with death 9 months after diagnosis despite surgery and chemotherapy. Radiation may have been an important factor in the development of this malignant tumor which is almost never seen in the pediatric age group.
Assuntos
Neoplasias Cerebelares/patologia , Neoplasias dos Nervos Cranianos/patologia , Glioblastoma/patologia , Meduloblastoma/patologia , Segunda Neoplasia Primária/patologia , Doenças do Nervo Óptico/patologia , Neoplasias Cerebelares/terapia , Criança , Terapia Combinada , Neoplasias dos Nervos Cranianos/etiologia , Glioblastoma/etiologia , Humanos , Masculino , Meduloblastoma/terapia , Doenças do Nervo Óptico/etiologiaRESUMO
Blastomycosis very rarely affects ocular structures other than the eyelid. It is even more unusual for involvement to occur in the absence of active widespread disease. The authors report a 71-year-old woman with unresponsive endophthalmitis of the right eye who underwent enucleation. Results of microscopic examination of the globe showed severe acute and chronic granulomatous and nongranulomatous endophthalmitis as well as numerous fungi having the histologic features of Blastomyces dermatitidis. Although constitutional symptoms (weight loss, fatigue, night sweats) were noted by the patient, multiple investigations failed to disclose any evidence of systemic disease.