RESUMO
Summary: Eosinophilic esophagitis (EoE) is a chronic allergen/immune-mediated disease leading to esophageal dysfunction. Food allergens play critical roles in the pathogenesis and treatment of EoE via different mechanisms. This study aimed to present the characteristics and evaluate the ability of skin prick test (SPT), skin prick to prick test (SPP) (IgE-mediated), and atopic patch test (APT) (cell-mediated) individually or simultaneously to diagnose food allergy in patients suffering from EoE. This prospective study was conducted on 58 patients with EoE. Seven patients (12.1%) were positive to only one, 3 (5.2%) were simultaneously positive to two, and 32 (55.2%) were simultaneously positive to three tests. Single and double sensitizations were totally 10.4% in IgE-mediated reactions, while 36.5% in cell-mediated reactions. In contrast, poly sensitization (> 2 allergens) was 51.7% in IgE-mediated tests and 20.7% in the cell-mediated test. Multiple sensitization findings showed egg white, milk, yolk, and soy were the most frequent allergens. Our findings indicate that EoE is early onset and associated with multiple food sensitizations, particularly via IgE-mediated mechanisms. These immune-mediated responses encompass both IgE-mediated (SPT and SPP) and cell-mediated (APT) reactions simultaneously not individually. Therefore, employing multiple assays may strengthen the diagnosis of food sensitization.
Assuntos
Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Imediata , Imunoglobulina E/sangue , Testes Cutâneos/métodos , Adolescente , Adulto , Alérgenos , Criança , Esofagite Eosinofílica/sangue , Esofagite Eosinofílica/diagnóstico , Feminino , Humanos , Imunidade Celular , Masculino , Estudos Prospectivos , Adulto JovemRESUMO
A cantilevered adhesive prosthesis was designed for a patient whose maxillary right central incisor was extracted. The width of the edentulous space was much greater than the mesiodistal width of the lost tooth, impeding the construction of a conventional fixed partial denture. A much more conservative and esthetic result was achieved by the construction of a cantilevered adhesive prosthesis in which the extracted tooth was used as a pontic.